Epstein‐Barr virus in exfoliated cells from the postnasal space

Hørding, Ulla; Albeck, Henrik; Katholm, Morten; Kristensen, H. Sund

doi:10.1111/j.1699-0463.1994.tb04885.x

Cited by 11 publications

(2 citation statements)

References 22 publications

(11 reference statements)

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“…Therefore, contrary to the fresh samples used in this study, molecular data from these types of samples (FFPET) is critical Our study showed that EBV was present in 6.3% of the control samples. this is in agreement with Studies conducted on exfoliated nasopharyngeal cells from healthy individuals in a high-risk population which revealed that 13% of the subjects had EBV, which is likely due to prior EBV exposure 27 . EBV detection in adenoid lesions suggests that further genetic and many environmental factors other than viral presence are necessary for tumour initiation and progression.…”

Section: Discussionsupporting

confidence: 92%

Detection of Epstein-Barr virus infections in Egyptian Nasopharyngeal Carcinoma patients

Youness,

EL-Ageery,

degla

et al. 2024

Egyptian Journal of Medical Microbiology

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Background: Epstein Barr Virus (EBV) is associated with at least 1% of global cancers including nasopharyngeal cancer (NPC). The EBV DNA importance in the prediction of NPC has received little attention in non-endemic areas. Objective of the current study was to investigate the frequency of EBV in NPC patients compared to control of healthy individuals, and to study the relationship between EBV infection and clinicopathological and demographic characteristics. Methodology:A Case control study was conducted at the Hospital of Mansoura University. Fresh biopsies were collected from NPC patients and healthy controls over 2-years period between 2021 and 2023. After previous DNA extraction, real-time polymerase chain reaction was performed for EBV detection. Results:The study included a total of 28 patient biopsies proven NPC and 32 control individuals. A significantly higher prevalence of EBV in patients as compared with controls. The presence of the EBV infection was determined in half of the NPC patients and 6.3% of the control group. There was none statistically significant association between the presence of EBV and the clinicopathological features. Conclusion: EBV is prevalent in the NPC cases compared with controls. Further studies with a larger sample size are required to determine the true burden of EBV-associated NPC in Egypt

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Section: Discussionsupporting

confidence: 92%

Detection of Epstein-Barr virus infections in Egyptian Nasopharyngeal Carcinoma patients

Youness,

EL-Ageery,

degla

et al. 2024

Egyptian Journal of Medical Microbiology

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“…Tungwood et al 33 detected EBV‐specific RNA in biopsies from normal nasopharynx in all 18 subjects they tested. Hoerding et al 34 found EBV DNA in nasopharynx biopsies of 35% (6/17) of healthy Danes and in 81% (44/55) of nondiseased Greenland Eskimos. They concluded that EBV infection leads to a chronic carrier state in the nasopharynx.…”

Section: Discussionmentioning

confidence: 99%

The Physiologic Reservoir of Epstein‐Barr Virus Does Not Map to Upper Aerodigestive Tissues

et al. 1998

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The human Epstein-Barr herpesvirus (EBV) has distinct oncogenic potential, but with over 90% of the adult world population infected, malignancy is a rare outcome of carrier status. However, EBV's association with over half of Hodgkin's and non-Hodgkin's lymphomas as well as several solid tumors, notably nasopharyngeal carcinoma, makes EBV-linked malignancies one of the largest single cancer entities. EBV is a B-lymphotropic virus, well controlled by surveillant T cells in immunocompetent hosts. To determine the presence and site of principal virus reservoirs is a likely prerequisite for understanding the etiology of EBV-associated tumors. Its near 100% association with nasopharyngeal carcinoma led to postulates that the upper aerodigestive tract tissue may be common sites of persistent latent or low-grade replicating infection. Using a protocol designed to avoid viral crosscontamination, the authors employed polymerase chain reaction to detect genomic EBV DNA sequences in 231 biopsies from different mucosal sites in the upper aerodigestive tract, as well as from salivary gland tissue and neck nodes in individuals not suspected to have EBV-related malignancy. Only two samples, one from oral cavity mucosa and one from parotid gland tissue, were positive for EBV. The observation that oropharyngeal tissue is not the principal EBV reservoir has mechanistic implications for the development of EBV-positive tumors in that locale.

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Presence of Epstein-Barr virus latent membrane protein 1 gene in the nasopharyngeal swabs from patients with nasopharyngeal carcinoma

et al. 2001

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Epstein‐Barr virus in exfoliated cells from the postnasal space

Cited by 11 publications

References 22 publications

Detection of Epstein-Barr virus infections in Egyptian Nasopharyngeal Carcinoma patients

Detection of Epstein-Barr virus infections in Egyptian Nasopharyngeal Carcinoma patients

The Physiologic Reservoir of Epstein‐Barr Virus Does Not Map to Upper Aerodigestive Tissues

Presence of Epstein-Barr virus latent membrane protein 1 gene in the nasopharyngeal swabs from patients with nasopharyngeal carcinoma

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