Epstein‐Barr virus immune response in high‐risk nasopharyngeal carcinoma families in Greenland

Friborg, Jeppe; Jarrett, Ruth F.; Falk, Kerstin I.; Koch, Anders; Olsen, Ove Rosing; Duncan, Pamela; Wohlfarht, Jan; Chen, Jen‐Yang; Melbye, Mads

doi:10.1002/jmv.21014

Cited by 8 publications

(10 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result was also found by other authors [34,35] except Friborg [23] who showed a clear trend toward concomitantly increasing anti-VCA IgA levels and PBMC EBV load.…”

Section: Discussionsupporting

confidence: 88%

“…In Greenland, using the same serologic markers as in this study, other authors did not show diVerences between 20 family members and 90 controls. However, they evidenced a general high seroprevalence of anti-VCA IgA in the two groups (25 vs. 20.5%) [23]. These percentages are higher than those found in Tunisian families (10.6 vs. 4.3%).…”

Section: Discussionmentioning

confidence: 71%

“…In this context, Friborg et al [23] observed that anti-VCA IgA positive individuals had signiWcantly higher EBV viral loads in the peripheral blood mononuclear cells (PBLC) (p < 0.01). Pickard et al reported the aggregation of EBV seroreactivity in individuals from high risk multiplex NPC families and noted that anti-VCA IgA seroprevalence in unaVected family members of NPC cases was 5-6 times higher than in members of the general Taiwanese community (p < 0.01) [24] with a negative viral load [25].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Complementary determination of Epstein-Barr virus DNA load and serum markers for nasopharyngeal carcinoma screening and early detection in individuals at risk in Tunisia

Baizig

Morand

Seigneurin

et al. 2011

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Because nasopharyngeal carcinoma (NPC) has a close association with Epstein-Barr virus (EBV), measuring serum EBV DNA and anti-EBV serum marker concentrations could be a feasible method for NPC diagnosis, monitoring and probably screening especially in a community at risk. The aim of this study was to determine the EBV pattern in sporadic NPC and in high risk NPC Tunisian families in order to evaluate their risk factors and help for NPC screening. The rates of anti-EBV antibodies and EBV DNA were determined in the serum of 47 healthy members randomly selected from 23 NPC multiplex families with two or more affected members, 93 healthy Tunisian community controls chosen with the same age, sex and geographic origin as unaffected individuals and 66 EBV positive sporadic NPC patients whose serum was available before and after treatment. Unexpectedly, significant lower concentrations of anti-EA (Early Antigen) IgG and anti-VCA (Viral Capsid Antigen) IgG were found in unaffected members from NPC families than in healthy controls while viral loads were negative in all the tested sera. For sporadic NPC patients, anti-EA IgG and anti-VCA IgA concentrations were significantly higher than in healthy controls and these rates decreased after treatment. The level of EBV DNA load varied according to the condition of the tumour. This study suggests that in the Tunisian NPC families, screening for malignancy is based on serum concentrations but not on EBV DNA load while in the sporadic NPC group, serologic markers and EBV DNA load are complementary for diagnosis and follow-up.

show abstract

“…This result was also found by other authors [34,35] except Friborg [23] who showed a clear trend toward concomitantly increasing anti-VCA IgA levels and PBMC EBV load.…”

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Complementary determination of Epstein-Barr virus DNA load and serum markers for nasopharyngeal carcinoma screening and early detection in individuals at risk in Tunisia

Baizig

Morand

Seigneurin

et al. 2011

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

“…Familial history is one of the contributors to the risk of NPC [ 31 - 33 ]. EBV serology testing in Taiwan indicated that unaffected members of high-risk families had increased seropositivity rate of anti-VCA IgA and anti-EBNA1 IgA compared to general healthy population, but this trend was not observed among Greenlandic Inuit [ 34 , 35 ]. Our present study using the eight EBV markers showed that the percentage of positive subjects was identical in the healthy populations from either high-risk NPC family or community.…”

Section: Discussionmentioning

confidence: 99%

Clinical values of multiple Epstein-Barr virus (EBV) serological biomarkers detected by xMAP technology

Xie

et al. 2009

J Transl Med

View full text Add to dashboard Cite

show abstract

“…Among multiple NPC case Inuit families, increased cancer proneness is to both of the EBV-associated tumors[39], whereas in Chinese only NPC is observed[40]. Furthermore, EBV seroreactivity has a different pattern from Chinese in that the very high prevalence of anti-VCA IgA precludes the utility of this antibody for NPC screening among Inuits[41]. This is an example of how a complex disease like NPC can have a definable genetic origin and be carried as a genetic marker by a specific population yet the risk distinction, here between risk-originating Chinese and descendant Inuits, and between Arctic-at-risk Inuit and Siberian-not-at-risk Inuit, is not a simple story of genetic determination and geographic spread.…”

mentioning

confidence: 99%

Nasopharyngeal carcinoma as a paradigm of cancer genetics

Simons

2011

Chin J Cancer

View full text Add to dashboard Cite

The unusual incidence patterns for nasopharyngeal carcinoma (NPC) in China, Northeast India, Arctic Inuit, Peninsular and island Southeast Asia, Polynesian Islanders, and North Africans indicate a role for NPC risk genes in Chinese, Chinese-related, and not-obviously Chinese-related populations. Renewed interest in NPC genetic risk has been stimulated by a hypothesis that NPC population patterns originated in Bai-Yue / pre-Austronesian–speaking aborigines and were dispersed during the last glacial maximum by Sundaland submersion. Five articles in this issue of the Chinese Journal of Cancer, first presented at a meeting on genetic aspects of NPC [National Cancer Center of Singapore (NCCS), February 20–21, 2010], are directed towards incidence patterns, to early detection of affected individuals within risk populations, and to the application of genetic technology advances to understanding the nature of high risk. Turnbull presents a general framework for understanding population migrations that underlie NPC and similar complex diseases, including other viral cancers. Trejaut et al. apply genetic markers to detail migration from East Asia through Taiwan to the populating of Island Polynesia. Migration dispersal in a westward direction took mongoloid peoples to modern day Northeast India adjacent to Western China (Xinjiang). NPC incidence in mongoloid Nagas ranks amongst the highest in the world, whereas elsewhere in India NPC is uncommon. Cao et al. detail incidence patterns in Southeast China that have occurred over recent decades. Finally, Ji et al. describe the utility of Epstein-Barr virus serostatus in early NPC detection. While genetic risk factors still remain largely unknown, human leukocyte antigen (HLA) genes have been a focus of attention since the discovery of an HLA association with NPC in 1973 and, two years later, that NPC susceptibility in highest-risk Cantonese involved the co-occurrence of multi-HLA locus combinations of HLA genes as chromosome combinations, or haplotypes (e.g. HLA-A2–B46), whereas in relatively lower-risk non-Cantonese Chinese (Hokkiens, Teochews) they appeared to act independently, a strength of association reflecting the 30–50-fold difference in incidence between highest risk Cantonese and lowest-risk Indians. The prototypic haplotype HLA-A2–B46 extends over megabases. An upstream DNA segment (near HLA-DPA1), has close similarity to Gorilla, with no obvious homology to Chimpanzee in current databases, suggesting that a reticulate model of primate evolution may be more appropriate than simple phylogeny. The DNA variation level in this segment is high enough for it to be a hominin remnant. HLA-B46 arose in mongoloids and remains largely limited to Chinese so the question arises as to whether the hominin candidate segment indicates an eastward trek of Homo neanderthalensis or the survival of much earlier Homo erectus? In 2011 sequencing technologies have finally caught up with the requirement to separate parental haplotypes. Recently achieved chromosome separation for whole genome...

show abstract

Epstein‐Barr virus immune response in high‐risk nasopharyngeal carcinoma families in Greenland

Cited by 8 publications

References 21 publications

Complementary determination of Epstein-Barr virus DNA load and serum markers for nasopharyngeal carcinoma screening and early detection in individuals at risk in Tunisia

Complementary determination of Epstein-Barr virus DNA load and serum markers for nasopharyngeal carcinoma screening and early detection in individuals at risk in Tunisia

Clinical values of multiple Epstein-Barr virus (EBV) serological biomarkers detected by xMAP technology

Nasopharyngeal carcinoma as a paradigm of cancer genetics

Contact Info

Product

Resources

About