Epstein-Barr virus hemorrhagic meningoencephalitis: case report and review of the literature

Ascenção, Bianca Branco; Gonçalves, Ana Catarina; Luís, Nuno; Sá, Joana; Brito, Ana Paula Santos Oliveira; Poças, José

doi:10.1007/s13365-016-0430-y

Cited by 16 publications

(4 citation statements)

References 11 publications

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“…Hemorrhagic encephalitis is either a form of ADEM/post infectious phenomenon. 19,20 The understanding remains that this represents the most severe end of the spectrum of hyperinflammation. Though acute phase reactants are elevated in both sepsis and PIMS-TS, hypofibrinogenemia is prominent in DIC, HLH, and also in acute liver failure.…”

Section: Discussionmentioning

confidence: 99%

Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 in Indian children: Pune experience

et al. 2021

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Background: Aim was to study the clinical profile, laboratory parameters and outcome of children with pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS).Methods: This is an observational study done in a PICU of a tertiary care teaching hospital in Pune conducted over seven months starting from 1st June to 31st December, 2020 and which included the children meeting the case definition of PIMS-TS.Results: A total 25 children were included of which 13 (52%) were males. Median age was 7 years. Fever of short duration was present in all children and 23 (92%) had gastrointestinal symptoms. 21 (84%) had features of shock while myocardial dysfunction was seen in eight (32%) children. Kawasaki disease like features were present in seven (28%) while five (20%) showed coronary artery dilatation. All had neutrophilia and lymphopenia while 10 (40%) showed thrombocytopenia. Interleukin-6 levels, done in six, and were found to be raised in all. SARS-CoV-2 RT-PCR and IgG antibody were positive in two while only IgG was positive in 14 (56%) children. Seven required mechanical ventilation while eleven were managed with HFNO. 16 (64%) children received both IVIG and steroids, two (8%) children received only IVIG while seven (28%) received only steroids. Two children each additionally received Tocilizumab and infliximab. 24 (96%) children survived.Conclusions: Fever, gastrointestinal symptoms and hypotensive shock were predominant features of PIMS-TS. 2/3rd of children had demonstrable SARS-CoV-2 antibodies. Cardiac dysfunction was seen in 1/3rd of the children. It is a life-threatening illness requiring critical interventions, multi-organ support and various immunomodulators.

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Section: Discussionmentioning

confidence: 99%

Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 in Indian children: Pune experience

et al. 2021

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“…Notably, EBV-DNA was detected in the PBL in the present case. EBV infection in CNS is known to cause hemorrhagic meningoencephalitis (18)(19)(20)(21)(22)(23). In two previous cases, perivascular inflammation was confirmed pathologically (19,23).…”

Section: Discussionmentioning

confidence: 91%

Rare Co-occurrence of Spinal Cord Hemorrhage from Radiation-induced Cavernous Hemangioma and Classical Hodgkin Lymphoma Post-transplant Lymphoproliferative Disorder

Shimizu,

Nagashima,

Matsukawa

et al. 2024

Intern. Med.

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Post-transplant lymphoproliferative disorders (PTLDs) are lymphoproliferative diseases that occur after solid organ transplantation or hematopoietic stem cell transplantation (HSCT). The development of PTLD is often associated with reactivation of Epstein-Barr virus (EBV). A 26-year-old woman with a history of HSCT and total-body irradiation developed spinal cord hemorrhage from a radiation-induced cavernous hemangioma (RICH) shortly after the development of classical Hodgkin lymphoma PTLD with EBV reactivation. Although little is known about the factors leading to hemorrhagic events from spinal cord RICH, we suspect that EBV reactivation may have been a factor contributing to the hemorrhage in the present case.

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“… 5 Few cases of intracranial hemorrhage associated with EBV infection, almost exclusively arising from brain parenchyma, have been published so far. 6 7 …”

Section: Figmentioning

confidence: 99%

Ischemic Stroke and Subarachnoid Hemorrhage following Epstein-Barr Virus Infection

Rios

Félix

Proença

et al. 2020

JNRP

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Epstein-Barr virus hemorrhagic meningoencephalitis: case report and review of the literature

Cited by 16 publications

References 11 publications

Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 in Indian children: Pune experience

Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 in Indian children: Pune experience

Rare Co-occurrence of Spinal Cord Hemorrhage from Radiation-induced Cavernous Hemangioma and Classical Hodgkin Lymphoma Post-transplant Lymphoproliferative Disorder

Ischemic Stroke and Subarachnoid Hemorrhage following Epstein-Barr Virus Infection

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