Epstein-Barr Virus Genome Deletions in Epstein-Barr Virus-Positive T/NK Cell Lymphoproliferative Diseases

Wongwiwat, Wiyada; Fournier, Benjamin; Bassano, Irene; Bayoumy, Amr; Karstegl, Claudio Elgueta; Styles, Christine T; Bridges, Ray; Lenoir, Christelle; Boutboul, David; Moshous, Despina; Neven, Bénédicte; Kanda, Teru; Morgan, Rhys G.; White, Rob; Latour, Sylvain; Farrell, Patrick J.

doi:10.1128/jvi.00394-22

Cited by 5 publications

(2 citation statements)

References 42 publications

(81 reference statements)

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“…6A-B). Therefore, to determine whether paraspeckle-like condensates are unique to KSHV, or occurred in other gammaherpesvirus infections, immunofluorescence studies were repeated in Epstein Barr Virus (EBV)-infected cells: 293-rJJ-L3s, which harbours a BAC EBV clone (the type 2 EBV Jijoye strain), which were reactivated via transfection of the EBV lytic proteins ZTA, RTA and BALF4 (48,49). Similar to KSHV, SFPQ re-localised from a diffuse nuclear staining observed during latency to form puncta that clustered around EBV replication compartments, indicated by Ea-D staining, at 24 and 48 hours post-lytic induction (Fig.…”

Section: Large Paraspeckle-like Condensates Are Formed In Gammaherpes...mentioning

confidence: 99%

Virus-induced paraspeckle-like condensates are essential hubs for gene expression and their formation drives genomic instability

Harper,

Harrington,

Hayward

et al. 2024

Preprint

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The nucleus is a highly structured environment containing multiple membraneless bodies formed through liquid liquid phase separation. These provide spatial separation and concentration of specific biomolecules enabling efficient and discrete processes to occur which regulate gene expression. One such nuclear body, paraspeckles, are comprised of multiple paraspeckle proteins, PSPs, built around the architectural RNA, NEAT1 2. Paraspeckle function is yet to be fully elucidated but has been implicated in a variety of developmental and disease scenarios. We demonstrate that Kaposi sarcoma associated herpesvirus drives formation of structurally distinct paraspeckles with a dramatically increased size and altered protein composition that are essential for productive lytic replication. We highlight these virus induced paraspeckle like structures form adjacent to virus replication centres, functioning as RNA processing hubs for both viral and cellular transcripts during infection. Notably, we reveal that PSP sequestration into virus-induced paraspeckle like structures results in increased genome instability during both KSHV and Epstein Barr virus infection, implicating their formation in virus mediated tumorigenesis.

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Section: Large Paraspeckle-like Condensates Are Formed In Gammaherpes...mentioning

confidence: 99%

Virus-induced paraspeckle-like condensates are essential hubs for gene expression and their formation drives genomic instability

Harper,

Harrington,

Hayward

et al. 2024

Preprint

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“…However, in some less common cases, cholestatic hepatitis, which is a rare form of acute hepatitis characterized by obstruction of bile flow, may occur sporadically. [46][47][48][49][50]…”

Section: Epstein-barr Virusmentioning

confidence: 99%

Viral hepatitis, hallmarks and molecular features

Vargas-Sierra,

Camara-Medina,

Vincze-Galicia

et al. 2023

psrua

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Hepatitis is a liver inflammation which has different etiologies, it can be caused pharmacologically or can be associated with fatty liver or alcohol consumption. However, viral infection as the most important cause. Recently, the World Health Organization (WHO) has published reports of outbreaks of hepatitis of unknown etiology in several countries in children less than 16 years. In this review we describe the general aspects of viral hepatitis, the molecular description of the hepatotropic viruses, laboratory findings, molecular diagnosis, prevention strategies. In addition, the main characteristics of some viruses that are not hepatotropic but have been previously reported to be related to some types of hepatitis are mentioned. Finally, a brief description of new cases of hepatitis of unknown origin is given and the adverse effects of SARS COV-2 vaccines are briefly discussed.

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Epstein-Barr virus: Biology and clinical disease

Damania

Kenney

Raab‐Traub

2022

Cell

146

102

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Epstein-Barr Virus Genome Deletions in Epstein-Barr Virus-Positive T/NK Cell Lymphoproliferative Diseases

Abstract: EBV contributes to several types of human cancer. Some cancers and nonmalignant lymphoproliferative diseases involving T or NK cells contain EBV.

Cited by 5 publications

References 42 publications

Virus-induced paraspeckle-like condensates are essential hubs for gene expression and their formation drives genomic instability

Virus-induced paraspeckle-like condensates are essential hubs for gene expression and their formation drives genomic instability

Viral hepatitis, hallmarks and molecular features

Epstein-Barr virus: Biology and clinical disease

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