Epstein-Barr virus (EBV) positive diffuse large B cell lymphoma of the elderly—Experience of a single center from Turkey

Özsan, Nazan; Cagirgan, Seckin; Saydam, Güray; Güneş, Ajda; Hekımgıl, Mıne

doi:10.1016/j.prp.2013.04.014

Cited by 10 publications

(5 citation statements)

References 22 publications

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“…These unfavorable factors were shared by both groups, which indicated that EBV positive DLBCL belongs to a unique entity with aggressive clinical features 7 11 13 14 15 20 43 , regardless of age. Since there is no uniform cut-off for EBV positivity, some reports attributed the inconsistent results to the different cut-off values used in different studies 7 11 13 14 44 45 46 . However, by appling two most frequently-used cut-off values, our study indicated that EBER positive patients harbored more unfavorable clinical and pathological features than EBER negative ones, regardless of the cut-off values of EBV.…”

Section: Discussionmentioning

confidence: 99%

Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age

Liang

Miao

et al. 2015

Sci Rep

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Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma (DLBCL) of the elderly is defined as patients older than 50 years alone. However, recent studies showed young patients with sound immune status could also be affected. In this study, we investigated the clinical features and outcomes of patients with EBV positive DLBCL in the different age groups using different EBER cut-off values. The prevalence of EBV positive DLBCL was 14.0% (35/250) and 10.4% (26/250) for EBER cut-off of 20% and 50%, respectively. With both EBER cut-off values, patients with EBV DLBCL shared many unfavorable prognostic characteristics, regardless of age. EBV positive patients, both in the elderly and young groups, showed significantly worse overall survival and progression-free survival than negative cases. Moreover, no significant differences of outcomes were identified between different age groups with EBV positive DLBCL. In conclusion, EBV positive DLBCL patients, regardless of age, shared similar poor prognostic features and showed worse outcome than negative cases. We suggest that the age criterion of EBV positive DLBCL of the elderly, and possibly the name itself, be modified in future.

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Section: Discussionmentioning

confidence: 99%

Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age

Liang

Miao

et al. 2015

Sci Rep

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“…For example, EBV is an extremely common infection that does not lead to cancer in most people. In a small subset, EBV may contribute to DLBCL (Kinch et al , 2013; Ozsan et al , 2013), whereas in most people it does not. Similarly, not all DLBCL cases are EBV-positive, reflecting heterogeneity in the aetiology even of the same NHL subtype.…”

Section: Discussionmentioning

confidence: 99%

Common infection-related conditions and risk of lymphoid malignancies in older individuals

et al. 2014

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Background:Chronic antigenic stimulation may initiate non-Hodgkin (NHL) and Hodgkin lymphoma (HL) development. Antecedent, infection-related conditions have been associated, but evidence by lymphoproliferative subtype is limited.Methods:From the US SEER-Medicare database, 44 191 NHL, 1832 HL and 200 000 population-based controls, frequency-matched to all SEER cancer cases, were selected. Logistic regression models, adjusted for potential confounders, compared infection-related conditions in controls with HL and NHL patients and by the NHL subtypes diffuse large B-cell, T-cell, follicular and marginal zone lymphoma (MZL). Stratification by race was undertaken.Results:Respiratory tract infections were broadly associated with NHL, particularly MZL. Skin infections were associated with a 15–28% increased risk of NHL and with most NHL subtypes, particularly cellulitis with T-cell lymphoma (OR 1.36, 95%CI 1.24–1.49). Only herpes zoster remained associated with HL following Bonferroni correction (OR 1.55, 95% CI 1.28–1.87). Gastrointestinal and urinary tract infections were not strongly associated with NHL or HL. In stratified analyses by race, sinusitis, pharyngitis, bronchitis and cellulitis showed stronger associations with total NHL in blacks than whites (P<0.001).Conclusions:Infections may contribute to the aetiologic pathway and/or be markers of underlying immune modulation. Precise elucidation of these mechanisms may provide important clues for understanding how immune disturbance contributes to lymphoma.

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“…To estimate the incidences for DLBCL and ENKTL-NT and proportions of EBV-related cases, we conducted several meta-analyses of proportions with a random effects model using the meta-package in the R programming language (version 4.0.2) (Balduzzi et al 2019 ). Studies describing the frequency of DLBCL as a proportion of NHL (Chang et al 2005 ; Aoki et al 2008 ; Chen et al 2008 ; Okan et al 2008 ; Engels et al 2010a , b ; Yoon et al 2010 ; Kim et al 2011 ; Wada et al 2011 ; Yang et al 2011 ; Laurini et al 2012 ; Sun et al 2012 ; Szumera-Cieckiewicz et al 2014 ; van Leeuwen et al 2014 ; Al-Hamadani et al 2015 ; Cao et al 2018 ; Intragumtornchai et al 2018 ), EBV-related DLBCL as a proportion of DLBCL (Hoeller et al 2010 ; Hofscheier et al 2011 ; Wada et al 2011 ; Ozsan et al 2013 ; Pan et al 2013 ; Ok et al 2014 ; Sato et al 2014 ; Xie et al 2014 ; Hong et al 2015 ; Lu et al 2015 ; Monabati et al 2016 ; Stuhlmann-Laeisz et al 2016 ; Cohen et al 2017 ; Ohashi et al 2017 ; Okamoto et al 2017 ; Tokuyama et al 2017 ; Beltran et al 2018 ; Miyagi et al 2020 ) and ENKTL-NT as a proportion of NHL (Aoki et al 2008 ; Yoon et al 2010 ; Kim et al 2011 ; Yang et al 2011 ; Laurini et al 2012 ; Sun et al 2012 ; Szumera-Cieckiewicz et al 2014 ; van Leeuwen et al 2014 ; Aviles 2015 ; Cao et al 2018 ; Intragumtornchai et al 2018 ; Agrawal et al 2021 ) were retrieved from the published literature. Through this analysis, 95% confidence intervals for each individual study were calculated along with an estimate for the pooled proportion and its 95% confidence interval.…”

Section: Methodsmentioning

confidence: 99%

Estimating the global burden of Epstein–Barr virus-related cancers

Wong

Meehan

Burrows

et al. 2021

J Cancer Res Clin Oncol

116

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Background More than 90% of the adult population globally is chronically infected by the Epstein–Barr virus (EBV). It is well established that EBV is associated with a number of malignancies, and advances in knowledge of EBV-related malignancies are being made every year. Several studies have analysed the global epidemiology and geographic distribution of EBV-related cancers. However, most have only described a single cancer type or subtype in isolation or limited their study to the three or four most common EBV-related cancers. This review will present an overview on the spectrum of cancers linked to EBV based on observations of associations and proportions in the published literature while also using these observations to estimate the incidence and mortality burden of some of these cancers. Method We have reviewed the literature on defining features, distribution and outcomes across six cancers with a relatively large EBV-related case burden: Nasopharyngeal carcinoma (NPC), Gastric carcinoma (GC), Hodgkin lymphoma (HL), Burkitt lymphoma (BL), Diffuse large B-cell lymphoma (DLBCL) and Extranodal NK/T-cell lymphoma, Nasal type (ENKTL-NT). We retrieved published region-specific EBV-related case proportions for NPC, GC, HL and BL and performed meta-analyses on pooled region-specific studies of EBV-related case proportions for DLBCL and ENKTL-NT. We match these pooled proportions with their respective regional incidence and mortality numbers retrieved from a publicly available cancer database. Additionally, we also reviewed the literature on several other less common EBV-related cancers to summarize their key characteristics herein. Conclusion We estimated that EBV-related cases from these six cancers accounted for 239,700–357,900 new cases and 137,900–208,700 deaths in 2020. This review highlights the significant global impact of EBV-related cancers and extends the spectrum of disease that could benefit from an EBV-specific therapeutic.

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Epstein-Barr virus (EBV) positive diffuse large B cell lymphoma of the elderly—Experience of a single center from Turkey

Cited by 10 publications

References 22 publications

Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age

Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age

Common infection-related conditions and risk of lymphoid malignancies in older individuals

Estimating the global burden of Epstein–Barr virus-related cancers

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