Epstein‐Barr virus DNA detection in the diagnosis of nasopharyngeal carcinoma

Abstract

PCR is an ideal tool for suggesting NPC and guiding the diagnostic workup in occult primary tumors, facilitating earlier diagnosis and reducing morbidity and mortality.

Higher incidence of nasopharyngeal carcinoma in some regions in the world confers for interplay between genetic factors and external stimuli

“…A number of reports show higher levels of antibodies (EBV-IgG) against the virus capsid protein (VCP) in these populations (73,74). Various EBNAs have also been detected in tumor cells of NPC (75,76). One subtype of the viral immediate-early gene BRLF1, BR1-C, and its gene product Rta may be associated with the tumorigenesis of NPC.…”

Accuracy of Diagnostic Methods for Detection of Head and Neck Primary Origin in Metastatic Neck Mass

“…EBVs latent membrane protein 1 is highly suspicious of having a central role in both initiation and progression of the tumor [76][77][78]. EBV-DNA is routinely detected by PCR with sensitivity and specifity close to 90% from FNAB samples [79][80][81][82].…”

“…A treatment-deescalation for HPV/p16 nonsmokers could be imaginable, either through omitting chemotherapy or even by using chemotherapy in order to reduce RT-dose, following the paradigm of current HNSCC trials [102]. Table 3 shows the largest published studies implementing chemotherapy and the agents used in each case [10,11,53,76,77,[79][80][81][82][83][84][85].…”

Epstein-Barr Virus Serology in the Detection and Screening of Nasopharyngeal Carcinoma

“…) for DNA in the diagnosis of NPC were: sensitivity 0.92 (95% confidence interval ( The presentation with "occult primary" of NPC is a diagnostic challenge for the clinician. Detection of EBV DNA by PCR in metastatic neck nodes has a good diagnostic rate (97.1%) (Yap et al, 2007). PCR is an ideal tool for suggesting occult primary NPC and guiding the diagnostic workup, facilitating earlier diagnosis and reducing morbidity and mortality.…”