Epstein–Barr virus: Dermatologic associations and implications

Hall, Lawrence David; Eminger, Lindsay A.; Hesterman, Kathleen S.; Heymann, Warren R.

doi:10.1016/j.jaad.2014.07.034

Cited by 53 publications

(33 citation statements)

References 188 publications

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“…Although our test results showed reactivation of EBV, which can be observed in the setting of other viral infections, we did not suspect that the rash in this patient was related to EBV. 6 Our observation can be included in the complex category of paraviral dermatoses. Owing to the current COVID-19 pandemic, clinicians should be aware of this new potential association.…”

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confidence: 91%

Digitate Papulosquamous Eruption Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection

et al. 2020

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confidence: 91%

Digitate Papulosquamous Eruption Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection

et al. 2020

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“…EBV is one of the most common isolated viruses in the adult population. 9 Typically, the primary infection occurs in the nasopharyngeal epithelial cells, and after a lytic cycle with viral replication, it remains inactive mainly within the memory B cells, but may also be present in T cells, natural killer cells, macrophages, monocytes, smooth muscle cells, and endothelial cells. 7 , 9 The EBV genome may express different combinations of nuclear antigens and latent membrane proteins, which may correlate with different patterns of latency.…”

Section: Discussionmentioning

confidence: 99%

“… 9 Typically, the primary infection occurs in the nasopharyngeal epithelial cells, and after a lytic cycle with viral replication, it remains inactive mainly within the memory B cells, but may also be present in T cells, natural killer cells, macrophages, monocytes, smooth muscle cells, and endothelial cells. 7 , 9 The EBV genome may express different combinations of nuclear antigens and latent membrane proteins, which may correlate with different patterns of latency. 9 The patient described in this case study could have had a latent infection and the reactivation of the virus could have caused both genital ulcers and meningitis, but the presence of genital ulcers associated with the patient’s sexual history raised the possibility of a primary infection by sexual transmission.…”

Section: Discussionmentioning

confidence: 99%

“… 7 , 9 The EBV genome may express different combinations of nuclear antigens and latent membrane proteins, which may correlate with different patterns of latency. 9 The patient described in this case study could have had a latent infection and the reactivation of the virus could have caused both genital ulcers and meningitis, but the presence of genital ulcers associated with the patient’s sexual history raised the possibility of a primary infection by sexual transmission.…”

Section: Discussionmentioning

confidence: 99%

“…Dermatologic manifestations of EBV infection are also diverse and include infectious mononucleosis, papular acrodermatitis of childhood (Gianotti–Crosti syndrome), hypersensitivity to mosquito bites, oral hair leukoplakia, histiocytic necrotizing lymphadenitis (Kikuchi–Fujimoto syndrome), hydroa vacciniforme, and genital ulcers. 9 , 12 , 13 …”

Section: Discussionmentioning

confidence: 99%

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Simultaneous genital ulcer and meningitis: a case of EBV infection

Rahhal

Nunes

Lopes

et al. 2016

ACR

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The Epstein-Barr virus (EBV) is associated with a broad spectrum of diseases, mainly because of its genomic characteristics, which result in different latency patterns in immune cells and infective mechanisms. The patient described in this report is a previously healthy young man who presented to the emergency department with clinical features consistent with meningitis and genital ulcers, which raised concern that the herpes simplex virus was the causative agent. However, the polymerase chain reaction of cerebral spinal fluid was positive for EBV. The authors highlight the importance of this infection among the differential diagnosis of central nervous system involvement and genital ulceration.

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Multiple cutaneous ulcers revealing a primary cutaneous Epstein‐Barr virus‐positive diffuse large B‐cell lymphoma

Tedbirt

Dubois

Cellier

et al. 2020

Clinical Case Reports

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Primary cutaneous Epstein-Barr virus-positive diffuse large B-cell lymphoma (PC-EBV-DLBCL) is an exceptional and aggressive neoplasia with a poorer prognosis than other cutaneous lymphoma. This case highlights this immunosenescence-associated lymphoid malignancy as an edifying cause of multiple skin ulcerations, distinct from other leg ulcers unrelated to arterial and venous disease. Approximately, 20% of cutaneous lymphomas are B-lymphocyte-derived malignancies exclusively involving cutaneous site at the time of diagnosis. Cutaneous B-cell lymphomas (CBCL) are classified into five distinct subgroups: primary cutaneous follicle center lymphoma (PCFCL); primary cutaneous marginal zone lymphoma (PCMZL); primary cutaneous diffuse large B-cell lymphoma (PC-DLBCL), leg type; intravascular diffuse large B-cell lymphoma (IV-DLBCL); and DLBCL, not otherwise specified (NOS). The prognosis of CBCL may vary depending on the subtype of CBCL. PCMZL and PCFCL are indolent forms, whereas PCLBCL, leg type, and IV-DLBCL have an intermediate to aggressive clinical course. The 2016 revision of the World Health Organization (WHO) classification of lymphoid malignancies recognized primary cutaneous Epstein-Barr virus (EBV)-positive DLBCL as a distinct entity within the group of "DLBCL NOS". 1 This is a rare but aggressive type of cutaneous lymphoma, which predominantly affects elderly and/or immunodeficient patients. 2 However, this entity must be distinguished from EBV-positive mucocutaneous ulcers (MCU)

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Epstein–Barr virus: Dermatologic associations and implications

Cited by 53 publications

References 188 publications

Digitate Papulosquamous Eruption Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Digitate Papulosquamous Eruption Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Simultaneous genital ulcer and meningitis: a case of EBV infection

Multiple cutaneous ulcers revealing a primary cutaneous Epstein‐Barr virus‐positive diffuse large B‐cell lymphoma

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