Epstein-Barr Virus BBLF1 Mediates Secretory Vesicle Transport to Facilitate Mature Virion Release

Uddin, Md Kamal; Watanabe, Takahiro; Arata, Masataka; Sato, Yoshitaka; Kimura, Hiroshi; Murata, Takayuki

doi:10.1128/jvi.00437-23

Cited by 3 publications

(2 citation statements)

References 59 publications

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“…BBRF3 (gN/gM) [68] and the KSHV glycoprotein gB [83] contribute to viral assembly and egress. Another study, using a combination of electron microscopy and subcellular fractionation analyses, demonstrated that BBLF1 knockout leads to the accumulation of virions in secretory vesicles, suggesting its importance in EBV virion release [42]. A recent study demonstrated that BGLF4 induces cytoskeletal rearrangement, which is the coordinately induced redistribution of cytoplasmic organelles.…”

Section: Trafficking Of Matured Virions To the Plasma Membrane And Ex...mentioning

confidence: 99%

Current Insights into the Maturation of Epstein–Barr Virus Particles

Nanbo

2024

Microorganisms

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The three subfamilies of herpesviruses (alphaherpesviruses, betaherpesviruses, and gammaherpesviruses) appear to share a unique mechanism for the maturation and egress of virions, mediated by several budding and fusion processes of various organelle membranes during replication, which prevents cellular membrane disruption. Newly synthesized viral DNA is packaged into capsids within the nucleus, which are subsequently released into the cytoplasm via sequential fusion (primary envelopment) and budding through the inner and outer nuclear membranes. Maturation concludes with tegumentation and the secondary envelopment of nucleocapsids, which are mediated by budding into various cell organelles. Intracellular compartments containing mature virions are transported to the plasma membrane via host vesicular trafficking machinery, where they fuse with the plasma membrane to extracellularly release mature virions. The entire process of viral maturation is orchestrated by sequential interactions between viral proteins and intracellular membranes. Compared with other herpesvirus subfamilies, the mechanisms of gammaherpesvirus maturation and egress remain poorly understood. This review summarizes the major findings, including recently updated information of the molecular mechanism underlying the maturation and egress process of the Epstein–Barr virus, a ubiquitous human gammaherpesvirus subfamily member that infects most of the population worldwide and is associated with a number of human malignancies.

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Section: Trafficking Of Matured Virions To the Plasma Membrane And Ex...mentioning

confidence: 99%

Current Insights into the Maturation of Epstein–Barr Virus Particles

Nanbo

2024

Microorganisms

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“…Additionally, this virus presents tegument proteins, whose functions are varied. They are associated with the release of mature virions, infectivity, viral production, and the inhibition of the host's antiviral response [172][173][174][175][176].…”

Section: Epstein-barr Virusmentioning

confidence: 99%

Understanding the Neurotrophic Virus Mechanisms and Their Potential Effect on Systemic Lupus Erythematosus Development

Uribe,

González,

Kalergis

et al. 2024

Brain Sciences

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Central nervous system (CNS) pathologies are a public health concern, with viral infections one of their principal causes. These viruses are known as neurotropic pathogens, characterized by their ability to infiltrate the CNS and thus interact with various cell populations, inducing several diseases. The immune response elicited by neurotropic viruses in the CNS is commanded mainly by microglia, which, together with other local cells, can secrete inflammatory cytokines to fight the infection. The most relevant neurotropic viruses are adenovirus (AdV), cytomegalovirus (CMV), enterovirus (EV), Epstein–Barr Virus (EBV), herpes simplex virus type 1 (HSV-1), and herpes simplex virus type 2 (HSV-2), lymphocytic choriomeningitis virus (LCMV), and the newly discovered SARS-CoV-2. Several studies have associated a viral infection with systemic lupus erythematosus (SLE) and neuropsychiatric lupus (NPSLE) manifestations. This article will review the knowledge about viral infections, CNS pathologies, and the immune response against them. Also, it allows us to understand the relevance of the different viral proteins in developing neuronal pathologies, SLE and NPSLE.

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Epstein-Barr Virus BBLF1 Mediates Secretory Vesicle Transport to Facilitate Mature Virion Release

Abstract: Several viruses have been linked to the development of cancer in humans. Epstein-Barr virus (EBV), the first identified human oncovirus, causes a wide range of cancers.

Cited by 3 publications

References 59 publications

Current Insights into the Maturation of Epstein–Barr Virus Particles

Current Insights into the Maturation of Epstein–Barr Virus Particles

Understanding the Neurotrophic Virus Mechanisms and Their Potential Effect on Systemic Lupus Erythematosus Development

Tegument proteins of Epstein-Barr virus: Diverse functions, complex networks, and oncogenesis

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