Epstein-Barr Virus BART Long Non-coding RNAs Function as Epigenetic Modulators in Nasopharyngeal Carcinoma

Verhoeven, Rob J. A.; Tong, S. Y.; Mok, Bobo Wing-Yee; Liu, Jiayan; He, Songtao; Zong, Jingfeng; Chen, Yixin; Tsao, Sai‐Wah; Lung, Maria Li; Chen, Honglin

doi:10.3389/fonc.2019.01120

Cited by 46 publications

(46 citation statements)

References 35 publications

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“…In molecule research, EBV infection is an important cause of nasopharyngeal carcinoma (NPC) [ 56 ]. Whether EBV infection occurs in LELC is currently a concern.…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-like carcinoma in liver not associated with Epstein-Barr virus: a report of 3 cases and literature review

Zhang

Tao

et al. 2020

Diagn Pathol

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Background Lymphoepithelioma-like carcinoma is a rare distinctive variant of liver cancer with unique epidemiological and pathological characteristics, characterized by dense lymphocyte infiltration. It can be divided into lymphoepithelioma-like hepatocellular carcinoma and lymphoepithelioma-like intrahepatic cholangiocarcinoma. Existing research shows that the prognosis of this tumor is good. To date, only 101 cases have been reported. Case presentation The first patient was a 62-year-old Chinese man with hepatitis B virus infection who presented with a single lesion in the liver. The patient underwent surgical treatment and was discharged on the 4th day. The patient was diagnosed with combined lymphoepithelioma-like hepatocellular carcinoma and cholangiocarcinoma; he has been alive for 15 months. The second patient was a 63-year-old Chinese woman with right upper abdominal pain and hepatitis B virus infection. The imaging examination revealed a single lesion in the liver. The patient underwent surgical treatment and was discharged 1 week later. The patient was diagnosed with lymphoepithelioma-like hepatocellular carcinoma and was considered to have recurrence in the lymph nodes approximately 2 years after the operation. The patient underwent local radiotherapy; she has been alive for 60 months. The third patient was a 50-year-old Chinese man with hepatitis B virus infection who presented with a single lesion in the liver and two enlarged lymph nodes. The patient received liver puncture before surgery to indicate lymph node metastasis and experienced local recurrence after liver resection. The patient underwent chemotherapy and radiotherapy. The patient was diagnosed with lymphoepithelioma-like hepatocellular carcinoma. The patient was deceased at 24-month follow-up. Conclusions This article reports 3 cases without Epstein-Barr virus and reviews the current literature, which suggests even mixed pathological type or locally advanced cases of LELC with lymph node metastasis and postoperative recurrence should be actively treated for a longer survival period.

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“…In molecule research, EBV infection is an important cause of nasopharyngeal carcinoma (NPC) [ 56 ]. Whether EBV infection occurs in LELC is currently a concern.…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-like carcinoma in liver not associated with Epstein-Barr virus: a report of 3 cases and literature review

Zhang

Tao

et al. 2020

Diagn Pathol

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“…In recent years, a number of studies have demonstrated that dysregulated lncRNAs play an important role in the carcinogenesis, development and metastasis of different types of tumor (33)(34)(35). A number of lncRNAs have been reported to be associated with the recurrence, metastasis and resistance to adjuvant therapy of patients with BC (36,37).…”

Section: Discussionmentioning

confidence: 99%

Development of a nine‑lncRNA signature as a novel prognostic marker of estrogen receptor‑negative breast cancer

Wang

Liu

et al. 2020

Oncol Lett

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Long non-coding RNAs (lncRNAs) have been demonstrated to be aberrantly expressed in several types of tumor, and dysregulated lncRNAs are suggested to play a prognostic role in breast cancer (BC). Estrogen receptor (ER) status is a prognostic factor in patients with ER-negative BC, which is associated with poor prognosis. Thus, the present study developed a prognostic lncRNA signature specifically for ER-negative BC, in order to predict the risk of post-surgery relapse and improve patient prognosis. A gene expression profile containing 1,631 lncRNAs was obtained by investigating and integrating publicly available cohorts of BC. Subsequently, a nine-lncRNA signature was developed and validated in two independent cohorts via the Cox regression model. Using the nine-lncRNA signature, patients in the discovery cohort were divided into high-and low-risk groups, with significantly different disease-free survival [DFS; hazard ratio (HR)=2.718, 95% confidence interval (CI)=2.115-3.494, P<0.0001]. Receiver operating characteristic curve analyses demonstrated that the area under the curve reached 0.908. Similar results were obtained in the two independent cohorts (HR=1.499, 95% CI=0.950-2.365, P=0.04; HR=1.262, 95% CI=1.056-1.510, P=0.01), respectively. Furthermore, the nine lncRNAs were demonstrated to play important roles in the cell invasion and metastasis of different types of tumor. The differentially expressed genes (DEGs) identified between the high-and low-risk groups were consistently high in the discovery and validation cohorts. Functional analysis indicated that these DEGs, as well as genes co-expressed with the nine lncRNAs, were involved in cancer-associated signaling pathways, all of which provide further evidence for the predictive ability of the nine-lncRNA signature. Overall, the present study developed a novel prognostic biomarker for ER-negative BC.

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“…Because of its nonspecific clinical manifestations, it is difficult to diagnose LELC before operation. EBV infection is an important cause of Nasopharyngeal carcinoma (NPC) [52] .…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-like hepatic carcinoma: A report of 3 cases and review of the literature

Zhang

Tao

et al. 2020

Preprint

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Background: Lymphoepithelioma-like hepatic carcinoma is a rare distinctive variant of liver cancer with unique epidemiological and pathological characteristics, characterized by dense lymphocyte infiltration. It can be divided into lymphoepithelioma-like hepatocellular carcinoma and lymphoepithelioma-like intrahepatic cholangiocarcinoma. Existing research shows that its prognosis is good. Up to now, only 101 cases have been reported. More rarely, combined lymphoepithelioma-like hepatocellular carcinoma and cholangiocarcinoma has been found. Case presentation: The first patient was a 62 years old Chinese man with hepatitis B virus infection presented with a single lesion in the liver. The patient underwent surgical treatment and was discharged on the 4th day. The patient was diagnosed as combined lymphoepithelioma-like hepatocellular carcinoma and cholangiocarcinoma and has been alive for 15 months. The second patient was a 63 years old Chinese woman with right upper abdominal pain and hepatitis B virus infection. The imaging examination a single lesion in the liver. The patient underwent surgical treatment and was discharged one week later. The patient was diagnosed as lymphoepithelioma-like hepatocellular carcinoma and was considered to be the recurrence of lymph nodes about 2 years after operation. The patient underwent local radiotherapy and has been alive for 60 months. The third patient was a 50 years old Chinese man with hepatitis B virus infection presented with a single lesion in the liver and two enlarged lymph nodes. The patient received liver puncture before operation to indicate lymph node metastasis and had local recurrence after liver resection. The patient underwent chemotherapy and radiotherapy. The patient was diagnosed as lymphoepithelioma-like hepatocellular carcinoma. Finally, the patient died at 24 months follow-up. Conclusions: This article reports 3 cases of LELC and reviews the current research discovery, which suggests that even the locally advanced patients of LELC with postoperative recurrence and preoperative lymph node metastasis should be actively treated and intervened for a longer survival period. Keywords: Liver Cancer, Lymphoepithelioma-like carcinoma, Hepatocellular carcinoma, Cholangiocarcinoma

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Epstein-Barr Virus BART Long Non-coding RNAs Function as Epigenetic Modulators in Nasopharyngeal Carcinoma

Cited by 46 publications

References 35 publications

Lymphoepithelioma-like carcinoma in liver not associated with Epstein-Barr virus: a report of 3 cases and literature review

Lymphoepithelioma-like carcinoma in liver not associated with Epstein-Barr virus: a report of 3 cases and literature review

Development of a nine‑lncRNA signature as a novel prognostic marker of estrogen receptor‑negative breast cancer

Lymphoepithelioma-like hepatic carcinoma: A report of 3 cases and review of the literature

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