Epstein-Barr virus-associated venous thromboembolism: A case report and review of the literature

Mashav, Noa; Saar, Nili; Chundadze, Tamar; Steinvil, Arie; Justo, Dan

doi:10.1016/j.thromres.2008.03.005

Cited by 16 publications

(20 citation statements)

References 7 publications

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“…MS risk is low in individuals who are EBV negative, but increases several fold following EBV infection. There is some evidence suggesting that EBV infection can act as a precipitating factor for venous thrombo-embolism in immuno-compromised patients [24]. The mechanisms by which EBV infection might trigger thrombosis are not fully understood, but include transient elevations of anti-phospholipid antibodies [25], and EBV-induced oxidative endothelial cell injury [26].…”

Section: Discussionmentioning

confidence: 99%

“…The mechanisms by which EBV infection might trigger thrombosis are not fully understood, but include transient elevations of anti-phospholipid antibodies [25], and EBV-induced oxidative endothelial cell injury [26]. The EBV virus was also found to have caused venous thrombosis in a patient with hereditary thrombophilia [24]. Persistent EBV infection in the small vein vessel wall can directly promote a pro-inflammatory, pro-coagulant, and pro-atherogenic environment [24].…”

Section: Discussionmentioning

confidence: 99%

“…The EBV virus was also found to have caused venous thrombosis in a patient with hereditary thrombophilia [24]. Persistent EBV infection in the small vein vessel wall can directly promote a pro-inflammatory, pro-coagulant, and pro-atherogenic environment [24]. Whether EBV infection may damage the venous endothelium, causing venous thromboses and strictures in the cranial and spinal venous drainage system, is unknown at this time.…”

Section: Discussionmentioning

confidence: 99%

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Risk Factors for Chronic Cerebrospinal Venous Insufficiency (CCSVI) in a Large Cohort of Volunteers

et al. 2011

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BackgroundThe role of intra- and extra-cranial venous system impairment in the pathogenesis of various vascular, inflammatory and neurodegenerative neurological disorders, as well as in aging, has not been studied in detail. Nor have risk factors been determined for increased susceptibility of venous pathology in the intra-cranial and extra-cranial veins. The aim of this study was to investigate the association between presence of a newly proposed vascular condition called chronic cerebrospinal venous insufficiency (CCSVI) and environmental factors in a large volunteer control group without known central nervous system pathology.Methods and FindingsThe data were collected in a prospective study from 252 subjects who were screened for medical history as part of the entry criteria and participated in the case-control study of CCSVI prevalence in multiple sclerosis (MS) patients, and then were analyzed post-hoc. All participants underwent physical and Doppler sonography examinations, and were assessed with a structured environmental questionnaire. Fullfilment of ≥2 positive venous hemodynamic (VH) criteria on Doppler sonography was considered indicative of CCSVI diagnosis. Risk and protective factors associated with CCSVI were analyzed using logistic regression analysis. Seventy (27.8%) subjects presented with CCSVI diagnosis and 153 (60.7%) presented with one or more VH criteria. The presence of heart disease (p = .001), especially heart murmurs (p = .007), a history of infectious mononucleosis (p = .002), and irritable bowel syndrome (p = .005) were associated with more frequent CCSVI diagnosis. Current or previous smoking (p = .029) showed a trend for association with more frequent CCSVI diagnosis, while use of dietary supplements (p = .018) showed a trend for association with less frequent CCSVI diagnosis.ConclusionsRisk factors for CCSVI differ from established risk factors for peripheral venous diseases. Vascular, infectious and inflammatory factors were associated with higher CCSVI frequency.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Risk Factors for Chronic Cerebrospinal Venous Insufficiency (CCSVI) in a Large Cohort of Volunteers

et al. 2011

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“…A few cases have been reported related to EBV. Predisposing risk factors for thrombosis have sometimes been found in the reported cases such asprotein C deficiency, hereditary thrombophilia, and transient elevation of anti-phospholipid antibodies (6,(10)(11)(12). Occasionally, EBV is associated with renal involvement.…”

Section: Discussionmentioning

confidence: 99%

Epstein Barr Virus Induced Thrombosis

2016

J Ann Eu Med

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ÖzetEpstein Barr virüs (EBV), çocuklarda ve genç erişkinlerde daha sık olmakla birlikte her yaşta görülebilmektedir. EBV, orafarinks salgıları, yakın temas, kan ve kontamine eşyalar ile bulaşabilmektedir. EBV infeksiyonunda klinik olarak ateş, boğaz ağrısı, halsizlik, generalize lenfadenopati gözlenmektedir. EBV ilişkili tromboz nadirdir ve çoğunlukla immün sistemi baskılanmış hastalarda raporlanmıştır. Olgumuz, 46 yaşında erkek; halsizlik, iştahsızlık ve karın ağrısı şikayetleri ile kliniğimize başvurdu. Olgumuzda, kronik aktif EBV tetiklediği superior mezenter ven tromboz tespit edildi (faktör V leiden mutasyonu bulundu). Mezenter iskemi sonucu opere edilen olguda kısa barsak sendromu gelişmesi üzerine rekürren akut böbrek hasarı (AKI) gelişti. Sıvı ve elektrolit replasmanı sağlanarak akut böbrek hasarı düzeltil-di. Biz bu makalede, süperior ven trombozu ve kalıtsal trombofili olan immün bağışık bir hasta sunduk. Anahtar KelimelerEpstein Bar Virüs; Tromboz; Akut Böbrek Hasarı AbstractEpstein Barr virus (EBV), which may develop at any age, is a common infection of childhood and young adulthood. EBV is transmitted by oropharyngeal secretions, close contact, blood, and by contaminated articles. Clinically, it is characterized by fever, sore throat, fatigue, and generalized lymphadenopathy. EBV-associated thrombosis has rarely been reported, mostly in immunocompromised patients.In this paper, we report on a 46-year old male admitted with fatigue, lack of appetite, and abdominal pain. In our case, chronic active EBV-triggered superior mesentericvein thrombosiswas detected; factor V leiden mutationwas found. The patient was operated on for mesenteric ischemia. Recurrent acute kidney injury (AKI) developed due to short bowel syndrome. AKI was treated with fluid and electrolyte replacement. In this article, we present an immunocompetent patient with superior mesentericvein thrombosis and hereditary thrombophilia

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“…Venous thromboembolism induced by primary EBV infection has seldom been reported in immunocompetent patients. 5,6 The mechanisms by which EBV infection might trigger thrombosis are not fully understood. There are several potential mechanisms, as hypothesis, of EBV-induced thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Disseminated Intravascular Coagulation and Venous Thromboembolism Due to Acute Epstein-Barr Virus Infection

Bader¹,

Haroon²,

Trahey³

et al. 2011

Infectious Diseases in Clinical Practice

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We describe a case of a healthy 61-year-old man who developed disseminated intravascular coagulation and venous thromboembolism secondary to acute Epstein-Barr virus (EBV) infection. The EBV was confirmed via serology and polymerase chain reaction. Although more common in children and young adults, acute EBV infection may also occur in middle-age and older adults and should be considered as a differential diagnosis in every patient presenting with disseminated intravascular coagulation.

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Epstein-Barr virus-associated venous thromboembolism: A case report and review of the literature

Cited by 16 publications

References 7 publications

Risk Factors for Chronic Cerebrospinal Venous Insufficiency (CCSVI) in a Large Cohort of Volunteers

Risk Factors for Chronic Cerebrospinal Venous Insufficiency (CCSVI) in a Large Cohort of Volunteers

Epstein Barr Virus Induced Thrombosis

Disseminated Intravascular Coagulation and Venous Thromboembolism Due to Acute Epstein-Barr Virus Infection

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