Epstein–Barr virus-associated peripheral T-cell lymphoma in adults with hydroa vacciniforme-like lesions

Cho, Kwang-Hyun; Kim, Chulwoo; Heo, Dae-Seog; Lee, Dong-Soon; Choi, Won Hoon; Rim, Jong-Hyun; Han, Won-Seok

doi:10.1046/j.1365-2230.2001.00805.x

Cited by 51 publications

(41 citation statements)

References 21 publications

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“…In this lesion, presence of intensive atypical lymphoid cells is observed histopathologically. Neoplastic cells are stained CD3 (+), CD20 (-) (12). In our patient, no such increase in atypical cells was observed and lymphocytic cells were positive both with CD3 and CD20.…”

Section: Arrows) Intensive Mixed Type Inflammation In the Dermis (H-contrasting

confidence: 48%

Hidroa vacciniforme

Kaptanoğlu¹,

Şahaloğlu²,

Comunoglu³

2014

Turk Arch Ped

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Section: Arrows) Intensive Mixed Type Inflammation In the Dermis (H-contrasting

confidence: 48%

Hidroa vacciniforme

Kaptanoğlu¹,

Şahaloğlu²,

Comunoglu³

2014

Turk Arch Ped

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“…Episodes of the disease appear precipitated by insect bites, to which the patients exhibit marked hypersensitivity. [46][47][48][49][50] The cutaneous infiltrates are EBV positive. A hemophagocytic syndrome may be seen, as expected from the EBV association.…”

Section: Hydroa Vacciniforme-like Lymphomamentioning

confidence: 99%

The Pathology of NK-Cell Lymphomas and Leukemias

Nava

Jaffe

2005

Advances in Anatomic Pathology

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Natural killer (NK) cell lymphomas and leukemias are a rare but clinically important group of neoplasms. Most of these tumors are aggressive, with a high rate of mortality. They include extranodal NK/T-cell lymphomas of nasal type and aggressive NK-cell leukemias. Both are Epstein-Barr virus (EBV) associated and show similar epidemiologic features. A closely related entity seen mainly in children is hydroa vacciniforme-like lymphoma, which also is EBV positive. EBV influences the pathophysiology of these tumors, through the induction of cytokines and chemokines. The differential diagnosis of NK-cell malignancies includes fulminant EBV-associated T-cell lymphoproliferative disorder, a condition referred to in the past as fatal infectious mononucleosis. Benign proliferations of NK cells can be seen in association with viral infection. The disease formerly referred to as blastic NK-cell lymphoma is now considered to be a malignancy derived from a dendritic cell precursor.

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“…3,10 HV-like lymphoma (HVLL) and systemic EBV-positive T-cell lymphoproliferative disease (LPD) of childhood were incorporated for the first time in the 2008 World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues in the subgroup of EBV-positive T-cell LPD of childhood. 11 HVLL is defined as an EBV-positive cutaneous T-cell lymphoma that occurs in children and less often in young adults 12 and may be associated with hypersensitivity to insect bites. Clinically, patients present with facial edema and recurrent vesiculopapular rash followed by ulceration and crusting.…”

Section: Introductionmentioning

confidence: 99%