Epstein-Barr virus-associated lymphoepithelial carcinoma of the larynx

Wassim, Kermani; Belcadhi, M; Sriha, Badreddine; Abdelkefi, M.

doi:10.1016/j.anorl.2015.05.004

Cited by 18 publications

(10 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A variety of other names have also been attributed to this tumor category, such as undifferentiated carcinoma of nasopharyngeal type, undifferentiated carcinoma with lymphoid stroma, lymphoepithelioma and lymphoepithelial like carcinoma, as well as recent names like lymphoepithelial carcinoma (LEC). Recently, Acuna, Hammas and Kermani have highlighted the etiopathogenesis of the disease in the background of viral etiology [ 11 , 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Keeping in view the poor outcome owing to distant metastasis, the role of induction chemotherapy has still remained controversial. Kermani used neoadjuvant chemotherapy with a response rate of 30% at the primary site and 50% at regional nodes [ 13 ]. Neo-adjuvant chemotherapy has been recommended in a few studies to reduce the disease volume in a clinically positive lymph node and to decrease the risk of distant failures [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…The result of the search was 36 studies, of which 8 were excluded due to descriptions of different histologies, while 7 were removed due to the presence of LECs in sites other than the larynx or hypopharynx. After a comprehensive review, 21 articles were identified in the English literature from 1968 to 2018 [ 1 , 2 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. Clinical information, including demographics, tumor location (sub-site), presenting symptoms, treatment modalities, viral etiology, genetic mutations and survival status, were extracted ( Table 1 ).…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Lymphoepithelial Carcinoma of Larynx and Hypopharynx: A Rare Clinicopathological Entity

Faisal

Hartenbach

Schratter

et al. 2020

Cancers

View full text Add to dashboard Cite

(1) Background: Lymphoepithelial carcinoma of the hypopharynx and larynx is a rare tumor with fewer than 50 cases in the published literature. We present a literature review to discuss the clinical findings, viral or genetic associations, diagnostic challenges, histopathological findings and therapeutic aspects of the disease. (2) Methods: A comprehensive literature review was performed through MEDLINE/PubMed from 1968 to 2018. We identified 21 studies comprising 46 patients. Data on all the clinicopathological features, diagnostic modalities, treatment options and viral or genetic etiology were extracted and analyzed using SPSS. (3) Results: The mean age of presentation was 64 years (range 40–82 years) and mostly involved males. The supraglottis and pyriform sinus were the most commonly involved sub-sites, with surgery as the preferred treatment modality. The presence of the Epstein–Barr virus possibly directs a viral etiology. The incidence of cervical and distant metastasis was 54% and 21%, respectively. The median survival time was 30 months. (4) Conclusions: Lymphoepithelial carcinoma of the hypopharynx is an aggressive tumor with a strong predilection for regional and distant metastasis. Surgery, in combination with adjuvant therapy, provides promising results. Immunohistochemistry helps in differentiating LEC from other pathologies.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Lymphoepithelial Carcinoma of Larynx and Hypopharynx: A Rare Clinicopathological Entity

Faisal

Hartenbach

Schratter

et al. 2020

Cancers

View full text Add to dashboard Cite

show abstract

“…Immunostaining with melanocyte differentiation markers (HMB45 or Melan-A) and lymphoid markers is useful to eliminate melanoma and lymphoma respectively. Nasopharyngeal carcinoma with laryngeal metastasis must also be eliminated [ 5 , 8 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelial carcinoma: a case report of a rare tumor of the larynx

et al. 2017

View full text Add to dashboard Cite

BackgroundLymphoepithelial carcinoma is a tumor mostly diagnosed in the nasopharynx, but it has also been described in a variety of nonnasopharyngeal sites. It is extremely rare in the larynx and should be distinguished from squamous cell carcinoma. Therefore, it must be known by clinicians, pathologists and oncologists. In this case report, we discuss its etiopathogeny, its epidemiological, clinical, pathological and therapeutic aspects, and its outcome.Case presentationAn 81-year-old Morrocan man, smoker for 40 years, presented with a 1 year history of dysphonia, dyspnea and dysphagia. Laryngoscopy showed a mass occupying supraglottic, glottic and subglottic levels of the larynx. Cervico-thoracic computed tomography scan showed a laryngeal wall thickening with cervical lymphadenopathy. Laryngeal biopsy was performed. Microscopic analysis and immunohistochemistry confirmed the diagnosis of laryngeal lymphoepithelial carcinoma. Immunostaining for LMP1 was negative.ConclusionLaryngeal lymphoepithelial carcinoma is an extremely rare and an aggressive tumor. It is rarely associated with the EBV. It must be regarded as a distinct entity. Radiotherapy is advisable as the unique therapy for local tumor. A correct diagnosis and a close collaboration between the pathologist and clinicians is mandatory for an optimal treatment strategy.

show abstract

“…lacrimal and salivary glands, esophagus, pancreas and middle ear. [70][71][72][73][74][75] Notably, our recent review on LEC of uterine cervix revealed no EBV infection in cancer cells in this rare primary cervical malignancy 76 .…”

Section: Status Of Ebv In Colorectal Cancermentioning

confidence: 99%

Epstein-Barr virus (EBV) status in colorectal cancer: a mini review

Bedri

Sultan

Alkhalaf

et al. 2018

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

Epstein-Barr virus (EBV) is a well-characterized oncovirus, associated with several malignancies. The complex and heterogeneous nature of colorectal cancer (CRC) has led to many epidemiological causal associations with CRC. However, a direct causal link between microbial infections and CRC has not been established yet. Our review indicates that the current evidence for the presence and role in EBV in CRC is insufficient and contradictory. The design of the analyzed studies, sample size as well as methodology used for EBV detection varied markedly and consequently may not lead to meaningful conclusions. The presence of EBV in other colorectal tumors (lymphomas, smooth muscle tumors) is in line with their status at other anatomic locations and may have therapeutic implications with EBV-specific vaccines. On the other hand, studies exploring EBV in colorectal adenoma-carcinoma sequence and its molecular genetic characteristics are largely missing and may significantly contribute to a better understanding of the role of EBV in CRC.

show abstract

Epstein-Barr virus-associated lymphoepithelial carcinoma of the larynx

Abstract: Lymphoepithelial carcinoma of the larynx is rare. Immunohistochemical examination is essential for the positive diagnosis. Epstein-Barr virus-associated lymphoepithelial carcinoma has been exceptionally reported. The radiosensitivity of this tumour allows conservative first-line treatment.

Cited by 18 publications

References 8 publications

Lymphoepithelial Carcinoma of Larynx and Hypopharynx: A Rare Clinicopathological Entity

Lymphoepithelial Carcinoma of Larynx and Hypopharynx: A Rare Clinicopathological Entity

Lymphoepithelial carcinoma: a case report of a rare tumor of the larynx

Epstein-Barr virus (EBV) status in colorectal cancer: a mini review

Contact Info

Product

Resources

About