Epstein–Barr virus‐associated large B‐cell lymphoma transformation in marginal zone B‐cell lymphoma: a series of four cases

Castañeda, Francisca Inmaculada Camacho; Dotor, Ana; Manso, Rebeca; Martín, Paloma; Pareja, E. Prieto; Esteban, Teresa Palomo; Vela, J. A. Garcia; Santonja, Carlos; Piris, Miguel Á.; Pinilla, Socorro María Rodriguez

doi:10.1111/his.14101

Cited by 9 publications

(7 citation statements)

References 32 publications

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“…This may be related to the fact that EBV does not infect tumor cells or the time of infection. According to Camacho Casta ñ EDA FI ( 8 ), one case of intranodal MZL was completely resolved after six cycles of chemotherapy. Lymph node biopsy showed scattered EBV-positive cells; 10 years later, the condition transformed into EBV-positive DLBCL.…”

Section: Discussionmentioning

confidence: 99%

“…EBV infection is associated with disease progression, and patients with EBV-positive lymphoma, diffuse large B-cell lymphoma, have a poor prognosis ( 4 ). Recent studies have found that some mature small B-cell lymphomas, such as follicular lymphoma (FL) and marginal zone lymphoma (MZL), are associated with EBV infection ( 5 – 8 ). Most of these cases are linked to aging, immunodeficiency, immunosuppression, and transplantation.…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathologic study of mantle cell lymphoma with epstein-barr virus infection: A case series and literature review

Zhou

et al. 2022

Front. Oncol.

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BackgroundMantle cell lymphoma (MCL) with Epstein–Barr virus (EBV) infection is rarely reported. The objective of this study was to analyze the prevalence and clinicopathological features of MCL with EBV infection in the largest series thus far.MethodsAfter screening 138 cases of MCL, we identified eight cases of MCL with EBV infection.ResultsMost of them (7/8) had non-neoplastic bystander cells with positivity for EBV and no expression of latent membrane protein 1 (LMP1) and EBV nuclear antigen 2 (EBNA2). The cases of MCL with EBER positivity did not have abnormal immune function or other lymphomas. Moreover, their histopathological morphology was indicative of classical MCL. Cases of MCL with EBER positivity exhibited statistically significant differences in lactate dehydrogenase, anemia status, and MCL international prognostic index grouping (P=0.008, P=0.02, P=0.001, and P=0.011, respectively). The differences between the two groups in age, sex ratio, clinical manifestations, and immunohistochemical phenotypes were not statistically significant.ConclusionsThe incidence of MCL with EBV infection was low (5.8%). Clinicopathologically, cases of MCL with EBER positivity were similar to their EBV-negative counterparts. Our findings revealed that most cells infected by EBV in MCL are background cells rather than tumor cells. This is inconsistent with data from previous studies, indicating that tumor cells in MCL may not be prone to EBV infection.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinicopathologic study of mantle cell lymphoma with epstein-barr virus infection: A case series and literature review

Zhou

et al. 2022

Front. Oncol.

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“…Primary gastric and thyroid DLBCLs often arise from antecedent EMZL through transformation, and almost all cases are EBV-negative. This suggests that most cases of EBV-positive DLBCL associated with chronic inflammation may not be related to EMZL and there may be a significant difference in oncogenesis between these two types of lymphoma, although some reports suggest that EBV infection might induce transformation from EMZL to DLBCL [14,15].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous marginal zone lymphoma of the nose arising after rhinoplasty with filler injection

2021

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Chronic inflammation induced by infection, autoimmune disorders, and immune reaction against foreign bodies are recognized as causative factors for the development of lymphoma. Here, a case of B cell lymphoma arising after augmentation rhinoplasty with filler injection is reported. A 48-year-old Japanese woman underwent rhinoplasty with filler injection at a cosmetic clinic 10 years ago. She, presently, came with complaints of a nodule at the nasal root. Histologic examination of the biopsy specimen revealed diffuse infiltration of centrocyte-like cells with plasmacytic differentiation in the subcutis and procerus muscle. Immunohistochemistry showed that the tumor cells were CD3−, CD5−, CD10−, CD20+, CD79+, bcl-2+, bcl-10+, IgG+, IgA −, and IgM−. In situ hybridization for Epstein-Barr virus small RNAs was negative. The final diagnosis was extranodal marginal zone lymphoma. This is a case of foreign body-induced carcinogenesis. Various aspects of chronic inflammation that propel lymphoma development are discussed with their morphology, immunophenotype, and viral association.

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“…It is worth notifying that recent data correlate EBV infection and large B cell lymphoma transformation in marginal zone B cell lymphoma. 126 Earlier report suggested that EBV may contribute to the pathogenesis of a small proportion of high-grade MALT lymphoma. 127 Analysis of molecular mechanisms of MZB cell transformation pointed the deregulation of NF-kB as one of the major players for MALT lymphomagenesis.…”

Section: Malt Lymphomamentioning

confidence: 99%

Putative role of marginal zone B cells in pathophysiological processes

Marinković

Marinkovic²

2020

Scand J Immunol

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The maintenance of inner integrity of an organism is founded on the proper performance of two immunity branches, innate and adaptive immune responses. Recently, it became apparent that subset of splenic B cells named marginal zone B cells (MZB cells) exhibits unique developmental and functional features that bridge these two immunity branches. Strategically positioned at the site where blood and lymph are filtered, MZB cells represent a population of sentinels that rapidly proliferate and differentiate into IgM plasmablast cells when encountered with blood‐borne, thymus‐independent (TI) Ags. Moreover, MZB cells have intrinsic capability to induce potent CD4+ helper T cell response and cytokine production upon stimulation with soluble antigens. Due to their ability to overcome a time gap prior the establishment of the full adaptive response towards pathogens, MZB cells connect and direct innate and adaptive immunity. An additional interesting characteristic of MZB cells is capacity to function as regulatory cells in autoimmune processes. MZB cells may also contribute to the control of autoimmunity via the induction of tolerance by apoptotic cells. Importantly, in the clear association with inflammation and autoimmunity, MZB cells may transform into MALT lymphoma, representing a concurrence point for the infection, immunity and malignancy. This paper presents an insight into the complex biology of marginal zone B cells and their role in intertwining and directing innate and adaptive immune processes at the physiological and pathological level.

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Epstein–Barr virus‐associated large B‐cell lymphoma transformation in marginal zone B‐cell lymphoma: a series of four cases

Cited by 9 publications

References 32 publications

Clinicopathologic study of mantle cell lymphoma with epstein-barr virus infection: A case series and literature review

Clinicopathologic study of mantle cell lymphoma with epstein-barr virus infection: A case series and literature review

Cutaneous marginal zone lymphoma of the nose arising after rhinoplasty with filler injection

Putative role of marginal zone B cells in pathophysiological processes

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