Epstein Barr virus and Multiple Sclerosis

Abstract

Cause of Multiple Sclerosis is not well known yet. There are theories that oint out a viral origen that may initiate the autoimmune response. There are a lot of biological agents that could be causative. Among them is Epstein Barr Virus but there are controversies about this topic. With the evaluation of the specific antibody index developed by Reiber, perhaps it will be possible to find some evidences that sign Epstein Barr virus like the cause of the disease. The aim of this paper is to evaluate the antibody index anti‐Epstein Barr virus in 27 patients with multiple sclerosis and 19 control cases. There were significant differences between Qspecific (Specific antibodies in CSF/Specific antibodies in serum) between the sclerosis multiple group and the control group (p<0.0001). The antibody index( Qspecific/Q IgG or Q lim) between both groups was not significant differences (p=0.0519). Anti‐Epstein Barr Qspecific in Multiple Sclerosis could contribute to clarify the etiology of this disease but it is necessary to increase the total of patients involved in the sample in order to confirm that the antibody index in patients could be definitively a probe of Epstein Barr virus as the causative of the disease.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

Mecanismos fisiopatológicos asociados al daño neurológico por Covid-19

“…De igual manera, en la etiopatogenia de algunas enfermedades autoinmunes, se ha demostrado que algunos virus pueden alterar la tolerancia inmunológica y originar células y moléculas autoreactivas. Tal es el caso del virus de Epstein-Barr incrementando el riesgo de padecer Esclerosis Múltiple (43). En el caso de los coronavirus, la infección por MERS-CoV, se ha relacionado con la ocurrencia de encefalomielitis y neurovasculitis (4,21).…”