Epstein‐barr and other herpes virus antibodies in children with acute leukemia

Gahrton, Gösta; Wahrén, Britta; Killander, D.; Foley, G. E.

doi:10.1002/ijc.2910080208

Cited by 12 publications

(2 citation statements)

References 29 publications

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“…It thus appears that an eariy infection with EBV may be associated with increased risk for developing leukaemia. This finding is at variance with the data of Gahrton et al (1971), but supports the evidence of subsequent studies, which suggest a role of infection in childhood leukemia (reviewed in Greaves and Alexander, 1993). In view of the fact that B lymphocytes are a major target for persistent EBV infection, this association is further stressed by our observation that B-ALL is more frequently found among EBV-positive young children than among EBV-negative ones.…”

Section: Discussioncontrasting

confidence: 57%

Sero-epidemiological analysis of the risk of virus infections for childhood leukaemia

et al. 1996

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Virus infections have been thought to be involved in the development of childhood leukaemia. In order to address this issue we determined, in a case-control study, the prevalence of antibodies to viruses infecting blood or bone-marrow cells [Epstein-Barr virus (EBV), human herpes virus type 6 (HHV-6), parvovirus B 191 as well as to the human virus known for its tumour-suppressive properties, the adeno-associated virus type 2 (AAV-2), in the sera of I21 children with leukaemia in Germany, and in 197 control individuals, hospitalized for other reasons, and matched for age and gender to the cases. In addition, we developed a questionnaire to be answered by the children's parents, in order to gain information on previous infections of the children as well as to calculate for factors which may influence serological findings. Comparative determination of the prevalence of antibodies against AAV-2, 8-I9 or HHV-6 revealed no significant differences in cases and controls. However, antibodies to EBV were more frequently found in children with leukaemia younger than 6 years of age (age at the time of diagnosis of leukaemia) than in controls. Apparently, infection with AAV-2 has no protective effect in childhood leukaemia, in contrast to results observed for other malignancies. Similarly, and in accordance with results on leukaemia in adults, we found no indication of a protective effect of infection with the parvovirus B-19. The data suggest that EBV, which is known to be involved in various lymphomas, may play a role in the development of childhood leukaemia in young children.o I996 Wiley-Liss, Inc.

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Section: Discussioncontrasting

confidence: 57%

Sero-epidemiological analysis of the risk of virus infections for childhood leukaemia

et al. 1996

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“…ANA were detected only in sera from certain cancer patients. Sera from 262 normal adults, 10 patients with IM, 12 patients with HD, and 5 patients with BL, thus representing both benign and malignant lymphoproliferative diseases, contained no ANA to the nuclei of CK cells.…”

Section: Resultsmentioning

confidence: 99%

Antinuclear antibodies and elevated anti-Epstein-Barr virus titers in cancer patients

McCormick¹,

McCormick²,

Trentin³

1976

Infect Immun

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One and one-half percent of human sera from patients seen at a clinic for treatment of cancer contai dA antibodies to the nuclei of chick kidney cells by indirect immunofluorescence tests. In the group of sera containing antinuclear antibodies, the geometric mean titer to Epstein-Barr virus (EBV) capsid antigen was significantly elevated. Sera obtained from normal adults or from patients with similar histological types of tumnors that possessed no antinuclea antibodies contained lower levels of anti-EBV antibodies. The elevated titers to EBV were correlated with the presence or absence of antinuclear antibodies and not with a particular type or site of neoplastic disease. While surveying human sera (K.

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Infectious mononucleosis prior to acute leukemia: A possible role for the epstein-barr virus

Levine

Stevens

Coccia

et al. 1972

Cancer

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Three cases of ALL preceded by IM are reported. One patient developed leukemia associated with an apparent recurrence of IM 17 months later. The other two patients, who were diagnosed as having IM one month prior to the appearance of their leukemia, had a poor response to chemotherapy and died after a brief illness. All patients had antibody to the EBV viral capsid antigen, and two had antibody to the EBV‐associated early antigen. Although IM and ALL are suspected of being caused by a virus, epidemiologic and laboratory studies indicate that the etiology of these diseases is distinct. Since IM has been well documented as a preceding event in cases of ALL as well as other lymphocytic neoplasms, it is possible that EBV may be able to activate or “switch‐on” an oncogenic process in a manner similar to that described for murine leukemia.

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Epstein‐barr and other herpes virus antibodies in children with acute leukemia

Cited by 12 publications

References 29 publications

Sero-epidemiological analysis of the risk of virus infections for childhood leukaemia

Sero-epidemiological analysis of the risk of virus infections for childhood leukaemia

Antinuclear antibodies and elevated anti-Epstein-Barr virus titers in cancer patients

Infectious mononucleosis prior to acute leukemia: A possible role for the epstein-barr virus

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