ePS06.5 Burkholderia cepacia complex acquisition: A threat in all CF patients?

Willekens, Julie; Wanyama, S.; Thomas, M.; Wachter, Elke De; Schutter, Iris De; Malfroot, Anne

doi:10.1016/s1569-1993(15)30173-9

Cited by 1 publication

(2 citation statements)

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“…11 Overall, the prevalence of Bcc infection in patients with CF is relatively low, ranging from less than 3% to approximately 8%, and appears to be higher in adult patients. 11,14,124,125 Despite their low prevalence, the clinical consequences of Bcc infection may be severe. For example, Bcc infection has been associated with increased morbidity and mortality in patients with CF.…”

Section: Nontuberculous Mycobacteriamentioning

confidence: 99%

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Bacterial infections in patients with primary ciliary dyskinesia: Comparison with cystic fibrosis

2017

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Primary ciliary dyskinesia (PCD) is an autosomal recessive disorder associated with severely impaired mucociliary clearance caused by defects in ciliary structure and function. Although recurrent bacterial infection of the respiratory tract is one of the major clinical features of this disease, PCD airway microbiology is understudied. Despite the differences in pathophysiology, assumptions about respiratory tract infections in patients with PCD are often extrapolated from cystic fibrosis (CF) airway microbiology. This review aims to summarize the current understanding of bacterial infections in patients with PCD, including infections with Pseudomonas aeruginosa, Staphylococcus aureus, and Moraxella catarrhalis, as it relates to bacterial infections in patients with CF. Further, we will discuss current and potential future treatment strategies aimed at improving the care of patients with PCD suffering from recurring bacterial infections.

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