EPR study of the structure of some oxyfluorides

Abdrakhmanov, R. S.; Garif'yanov, N. S.; Semenova, E. I.

doi:10.1007/bf00738840

Cited by 2 publications

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“…The +5 oxidation state of chromium, Cr(V), is a known intracellular reduction product of the carcinogen chromate, Cr(VI). − While there is much evidence that Cr(V) participates in the mechanism of Cr(VI) carcinogenesis, , little spectroscopic evidence for binding of Cr(V) to DNA and/or DNA substituents via a ligand exchange process has been reported. Previously, Cr(V)−phosphate complexes had been observed only during the reduction of Cr(VI) in concentrated ortho-, meta-, and pyrophosphoric acids. , In this paper, we demonstrate the ability of a model mutagenic Cr(V) complex to undergo ligand exchange in aqueous solutions and to bind in a monodentate fashion with phosphate and in a bidentate chelate with pyrophosphate. Our findings suggest a mechanism whereby Cr(V) formed through intracellular reduction of Cr(VI) can undergo ligand exchange and bind to the phosphate moieties present within both DNA and deoxyribonucleotides.…”

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confidence: 65%

EPR Evidence for Chromium(V) Binding to Phosphate and Pyrophosphate: Implications for Chromium(V)−DNA Interactions

Sugden

Wetterhahn²

1996

Inorg. Chem.

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Reactions of Cr(V) with phosphate and pyrophosphate were examined as models for ligand exchange binding to DNA and deoxyribonucleotides. The initial Cr(V) complex, [Cr(ehba)2O]-, can undergo ligand exchange with either one pyrophosphate, to form [Cr(ehba)(H2P2O7)O]-, or two pyrophosphates, to form [Cr(H2P2O7)2O]-, with a concomitant geometry change from trigonal bipyramidal to square pyramidal. Reaction with free phosphate produces two less stable monodentate Cr(V)−phosphate complexes which are assigned as meridional and facial isomers of cis-[Cr(ehba)2(H2PO4)O]2-.

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