2022
DOI: 10.1016/j.bcp.2021.114866
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Epoxylipids and soluble epoxide hydrolase in heart diseases

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Cited by 14 publications
(11 citation statements)
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“…We cannot not rule out that EPHX2 regulation of other EpFAs does not contribute, at least in part, to the development of cardiovascular disease or the postischemic recovery of heart function in vivo . The combination of omega-3 supplementation and EPHX2 inhibition may synergistically improve I/R recovery, as it does for other cardiovascular outcomes ( 47 ).…”
Section: Discussionmentioning
confidence: 99%
“…We cannot not rule out that EPHX2 regulation of other EpFAs does not contribute, at least in part, to the development of cardiovascular disease or the postischemic recovery of heart function in vivo . The combination of omega-3 supplementation and EPHX2 inhibition may synergistically improve I/R recovery, as it does for other cardiovascular outcomes ( 47 ).…”
Section: Discussionmentioning
confidence: 99%
“…It has been demonstrated that TGF-β1 induces the expression of SPHK1 to stimulate collagen production in both cardiac fibroblasts and myofibroblasts through S1P signaling [ 54 , 55 ]. The Ephx2 gene encodes for soluble epoxide hydrolase (sEH) involved in the metabolism of arachidonic acid, a polyunsaturated fatty acid released into the cytosol in response to cardiac stressors [ 56 ]. sEH genetic ablation and pharmacological inhibition have been shown to exert cardioprotective actions in myocardial infarction and HF, improving mitochondrial function, reducing oxidative stress and inflammation, and opposing apoptosis [ 56 ].…”
Section: Discussionmentioning
confidence: 99%
“…The Ephx2 gene encodes for soluble epoxide hydrolase (sEH) involved in the metabolism of arachidonic acid, a polyunsaturated fatty acid released into the cytosol in response to cardiac stressors [ 56 ]. sEH genetic ablation and pharmacological inhibition have been shown to exert cardioprotective actions in myocardial infarction and HF, improving mitochondrial function, reducing oxidative stress and inflammation, and opposing apoptosis [ 56 ]. Although RAGE activation has been associated with lipid accumulation and peroxidation in several organs [ 57 , 58 , 59 ], its specific role in intramyocardial lipid accumulation remains unknown.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, isolated and cultured vibrissae also grew longer when either the sEH was not expressed or the enzyme was inhibited. Since sEH metabolizes PUFA epoxides to their vicinal diols [ 47 ], LC–MS/MS was used to determine which PUFA metabolites in whisker follicles were affected by sEH deletion. Clear changes in only one epoxide/diol pair, i.e., 12,13-EpOME/DiHOME were detected, and of these, only the sEH substrate; 12,13-EpOME, stimulated whisker growth.…”
Section: Discussionmentioning
confidence: 99%