Epizootiology of Chagas disease near a forest settlement in French Guiana

Julien-Laferrière, Didier; Esterre, P.; Frenay, Claire; Dedet, Jean-Pierre

doi:10.1016/0035-9203(89)90645-7

Cited by 12 publications

(2 citation statements)

References 8 publications

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“…Although the present study was carried out at a site of T . cruzi transmission [ 38 ] and there is the possibility of anti- Leishmania serology presenting cross-reactivity with antibodies induced by T . cruzi antigens [ 39 ], serological results for T .…”

Section: Discussionmentioning

confidence: 99%

Clinical and parasitological features of Leishmania infection among gold miners in the Oiapoque basin, an international Brazil-French Guiana border

Mosquera Atehortua,

Figueira da Silva,

Mafra

et al. 2024

PLoS Negl Trop Dis

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Gold miners working illegally in mines live in poor health conditions related to their strenuous work and precarious housing. Therefore, they are at higher risk for infectious diseases. American tegumentary leishmaniasis (ATL) appears to be of great concern to the population living in the Guiana Shield region. Our aim was to describe their demographic characteristics, the clinical features of cutaneous leishmaniasis (CL), and the frequency of Leishmania infection in people working in illegal gold mines in French Guiana. A cross-sectional study was carried out from October to December 2019 in Oiapoque city, Amapá, Brazil. Indeed, many gold miners working in French Guiana are originally from Brazil, and from Oiapoque in particular. A total of 105 participants from 31 different mining sites in French Guiana were recruited. Suspected Leishmania infection was confirmed by the following: detection of kDNA in blood or the lesion site; detection of specific antibodies; or detection of IFN-γ release after blood incubation with leishmanial antigens (IGRA-Leish). Nine active CL cases, 38 healed ATL (hATL) and 58 cases with no history of ATL (noATL), were identified. Only half of the treated hATL (50.0%; n = 14) reported having been assisted by a health care unit and the others treated themselves. PCR-kDNA for Leishmania was positive in the blood of 100% of CL cases. Curiously, blood PCR-kDNA was positive in 13% of hATL patients and in 15.5% of noATL patients. The IGRA-Leish was positive in 60.5% of hATL and in 37.9% of noATL. In addition to scars suggestive of CL, 71% of hATL had laboratory evidence of Leishmania infection. Restriction fragment polymorphism (RFLP) of the hsp70 gene identified a sympatric circulation of L. (V.) guyanensis (n = 4), L. (V.) braziliensis (n = 1), L. (L.) amazonensis (n = 2), L. (V.) shawi (n = 1) and L. (V.) naiffi/shawi (n = 1). Taking the laboratory techniques and the clinical evaluations together, 76% (n = 80) of the 105 participants had evidence of Leishmania infection. These results suggests that illegal gold miners working in French Guiana are at high risk for infection with different species of Leishmania, but their illegal condition and remoteness make it difficult for them to access health services.

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Section: Discussionmentioning

confidence: 99%

Clinical and parasitological features of Leishmania infection among gold miners in the Oiapoque basin, an international Brazil-French Guiana border

Mosquera Atehortua,

Figueira da Silva,

Mafra

et al. 2024

PLoS Negl Trop Dis

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“…It is currently rare in French Guiana or in rural villages if there is a domestic or peridomestic cycle, as was suggested more than 10 years ago in Cayenne and Cacao. 6 The possible existence of such a cycle must be studied despite the absence of documented Chagas disease cases in these areas for more than 15 years. A recent serological study involving ELISA with 1,500 sera collected between 1992 and 1998 from subjects originating from all over the country showed an overall seroprevalence of 0.5% when considering only specific IgG antibodies (Aznar C and others, unpublished data).…”

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Four cases of acute chagasic myocarditis in French Guiana.

Carme

Aune²,

Aznar³

et al. 2001

The American Journal of Tropical Medicine and Hygiene

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Isolation of Leishmania species from wild mammals in French Guiana

Dedet

Chatenay

1989

Transactions of the Royal Society of Tropical Medicine and Hygi

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Between 1981 and 1987, 486 wild mammals collected from 13 sites in French Guiana were examined for Leishmania. Eleven of 31 two-toed sloths, Choloepus didactylus, were infected, 4 of the isolates being identified as L. braziliensis guyanensis. This species was also found in 2 Didelphis marsupialis and 2 Proechimys sp. L. mexicana amazonensis was isolated from 3 Proechimys sp., 2 of which were P. cuvieri. The role of these mammals in the life cycles of the 2 anthropotropic species of Leishmania encountered in French Guiana is discussed.

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Epizootiology of Chagas disease near a forest settlement in French Guiana

Cited by 12 publications

References 8 publications

Clinical and parasitological features of Leishmania infection among gold miners in the Oiapoque basin, an international Brazil-French Guiana border

Clinical and parasitological features of Leishmania infection among gold miners in the Oiapoque basin, an international Brazil-French Guiana border

Four cases of acute chagasic myocarditis in French Guiana.

Isolation of Leishmania species from wild mammals in French Guiana

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