Epizootic haemorrhagic disease virus type 7 infection in cattle in Israel

Yadin, Hagai; Brenner, J.; Bumbrov, V.; Oved, Z.; Stram, Yehuda; Klement, Eyal; Perl, S.; Anthony, Simon J.; Maan, Sushila; Batten, Carrie; Mertens, Peter P. C.

doi:10.1136/vr.162.2.53

Cited by 92 publications

(100 citation statements)

References 25 publications

(48 reference statements)

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“…35 Severe clinical disease in cattle, however, was reported with an outbreak of EHDV serotype 7 in Israel. 45 It is difficult to predict how exotic serotypes of these viruses could affect North American livestock and wildlife. The outbreak of BTV serotype 8 in Europe has had a greater impact than previous experience would predict.…”

Section: Introductionmentioning

confidence: 99%

A Multiplex Real-Time Reverse Transcription Polymerase Chain Reaction Assay for Detection and Differentiation ofBluetongue VirusandEpizootic Hemorrhagic Disease VirusSerogroups

et al. 2009

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Abstract. Bluetongue virus (BTV) causes disease in domestic and wild ruminants and results in significant economic loss. The closely related Epizootic hemorrhagic disease virus (EHDV) has been associated with bluetongue-like disease in cattle. Although U.S. EHDV strains have not been experimentally proven to cause disease in cattle, there is serologic evidence of infection in cattle. Therefore, rapid diagnosis and differentiation of BTV and EHDV is required. The genetic sequence information and bioinformatic analysis necessary to design a real-time reverse transcription polymerase chain reaction (RT-PCR) assay for the early detection of indigenous and exotic BTV and EHDV is described. This sequence data foundation focused on 2 conserved target genes: one that is highly expressed in infected mammalian cells, and the other is highly expressed in infected insect cells. The analysis of all BTV and EHDV prototype strains indicated that a complex primer design was necessary for both a virus group-comprehensive and virus group-specific gene amplification diagnostic test. This information has been used as the basis for the development of a rapid multiplex BTV-EHDV real-time RT-PCR that detects all known serotypes of both viruses and distinguishes between BTV and EHDV serogroups. The sensitivity of this rapid, single-tube, real-time RT-PCR assay is sufficient for diagnostic application, without the contamination problems associated with standard gel-based RT-PCR, especially nested RT-PCR tests.

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Section: Introductionmentioning

confidence: 99%

A Multiplex Real-Time Reverse Transcription Polymerase Chain Reaction Assay for Detection and Differentiation ofBluetongue VirusandEpizootic Hemorrhagic Disease VirusSerogroups

et al. 2009

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“…The 2006 outbreak of a 'bluetongue-like' disease in Israeli dairy herds is an example that also had significant economic consequences on the dairy industry (Kedmi et al, 2010b;Yadin et al, 2008). This outbreak was caused by epizootic hemorrhagic disease virus (EHDV), which had not been reported previously in Israel (Kedmi et al, 2010a).…”

Section: Introductionmentioning

confidence: 94%

“…It was also demonstrated that the primary US vector for BTV, Culicoides sonorensis, is capable of becoming infected and transmitting EHDV-7 (Ruder et al, 2012b). Sequence analyses of a virus strain isolated from the EHDV-7 2006 outbreak have been limited to six of the 10 gene segments (Maan et al, 2010a;Yadin et al, 2008). In this study, a complete genome sequence analysis of three EHDV-7 isolates from the 2006 disease outbreak in Israeli dairy cattle was performed to determine the potential variation among strains and the origin of this introduced virus.…”

Section: Introductionmentioning

confidence: 99%

Genetic characterization of epizootic hemorrhagic disease virus strains isolated from cattle in Israel

Wilson

Ruder

Klement

et al. 2015

Journal of General Virology

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Epizootic hemorrhagic disease virus (EHDV), a member of the genus Orbivirus not reported previously in Israel, was isolated from Israeli cattle during a 'bluetongue-like' disease outbreak in 2006. To ascertain the origin of this new virus, three isolates from the outbreak were fully sequenced and compared with available sequences. Whilst the L2 gene segment clustered with the Australian EHDV serotype 7 (EHDV-7) reference strain, most of the other segments were clustered with EHDV isolates of African/Middle East origin, specifically Bahrain, Nigeria and South Africa. The M6 gene had genetic relatedness to the Australian/Asian strains, but with the limited data available the significance of this relationship is unclear. Only one EHDV-7 L2 sequence was available, and as this gene encodes the serotype-specific epitope, the relationship of these EHDV-7 L2 genes to an Australian EHDV-7 reflects the serotype association, not necessarily the origin. The genetic data indicated that the strains affecting Israel in 2006 may have been related to similar outbreaks that occurred in North Africa in the same year. This finding also supports the hypothesis that EHDV entered Israel during 2006 and was not present there before this outbreak.

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“…Since the initial description of EHD in the eastern United States, EHDV infection of wild and domestic ungulates has been identified elsewhere in the Americas (including the Caribbean islands and both Central and South America), Africa, Asia (including Eastern, Central and Southeast Asia), Australia, Indian Ocean islands such as Mauritius and Reunion, and the Middle East (4,14,16,25,30,(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55). Although infection of domestic livestock is prevalent in many endemic areas, EHDV only rarely causes overt disease in livestock species and apparently only in cattle and not small ruminants (4,23).…”

Section: Introductionmentioning

confidence: 99%

Epizootic haemorrhagic disease

Maclachlan¹,

Zientara²,

Savini³

et al. 2015

Rev. Sci. Tech. OIE

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SummaryEpizootic haemorrhagic disease (EHD) is an arthropod-transmitted viral disease of certain wild ungulates, notably North American white-tailed deer and, more rarely, cattle. The disease in white-tailed deer results from vascular injury analogous to that caused by bluetongue virus (BTV), to which EHD virus (EHDV) is closely related. There are seven serotypes of EHDV recognised, and Ibaraki virus, which is the cause of sporadic disease outbreaks in cattle in Asia, is included in EHDV serotype 2. The global distribution and epidemiology of BTV and EHDV infections are also similar, as both viruses occur throughout temperate and tropical regions of the world where they are transmitted by biting Culicoides midges and infect a wide variety of domestic and wild ungulates. However, the global distribution and epidemiology of EHDV infection are less well characterised than they are for BTV. Whereas most natural and experimental EHDV infections (other than Ibaraki virus infection) of livestock are subclinical or asymptomatic, outbreaks of EHD have recently been reported among cattle in the Mediterranean Basin, Reunion Island, South Africa, and the United States. Accurate and convenient laboratory tests are increasingly available for the sensitive and specific serological and virological diagnosis of EHDV infection and confirmation of EHD in animals, but commercial vaccines are available only for prevention of Ibaraki disease and not for protection against other strains and serotypes of EHDV.

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Epizootic haemorrhagic disease virus type 7 infection in cattle in Israel

Cited by 92 publications

References 25 publications

A Multiplex Real-Time Reverse Transcription Polymerase Chain Reaction Assay for Detection and Differentiation ofBluetongue VirusandEpizootic Hemorrhagic Disease VirusSerogroups

A Multiplex Real-Time Reverse Transcription Polymerase Chain Reaction Assay for Detection and Differentiation ofBluetongue VirusandEpizootic Hemorrhagic Disease VirusSerogroups

Genetic characterization of epizootic hemorrhagic disease virus strains isolated from cattle in Israel

Epizootic haemorrhagic disease

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