“…Immune reponses to the 163/164 region of the SARS-CoV-2 spike protein have been observed in other studies (Deng et al, 2021;Dykema et al, 2021;Low et al, 2021;Loyal et al, 2021;Mateus et al, 2020;Saini et al, 2021;Tarke et al, 2021;Woldemeskel et al, 2021). An overlapping epitope accessible in the pre-fusion conformation was recognized by antibodies from COVID-19 donors as one of the most highly recognized linear epitopes, and antibodies recognizing this sequence were detected in both COVID-19 and unexposed donors (Poh et al, 2020;Shrock et al, 2020;Voss et al, 2021). Several studies of CD4+ and CD8+ T cell responses in SARS-CoV-2 donors, including unbiased epitope screens as well as those based on MHC-binding predictions, identified peptides overlapping the S811-831 sequence among many others (Deng et al, 2021;Dykema et al, 2021;Low et al, 2021;Saini et al, 2021;Tarke et al, 2021;Woldemeskel et al, 2021).…”