Epitope(s) involving amino acids of the fusion loop of Japanese encephalitis virus envelope protein is(are) important to elicit protective immunity
Yi-Chin Fan,
Jo-Mei Chen,
Yi-Ying Chen
et al.
Abstract:Dengue vaccine candidates have been shown to improve vaccine safety and efficacy by altering the residues or accessibility of the fusion loop on the virus envelope protein domain II (DII
FL
) in an
ex vivo
animal study. The current study aimed to comprehensively investigate the impact of DII
FL
mutations on the antigenicity, immunogenicity, and protective efficacy of Japanese encephalitis virus (JEV) virus-like particles (VLPs)… Show more
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