Epitope design of L1 protein for vaccine production against Human Papilloma Virus types 16 and 18

Baidya, Sunanda; Das, Rasel; Kabir, Md. Golam; Arifuzzaman, Md.

doi:10.6026/97320630013086

Cited by 10 publications

(18 citation statements)

References 61 publications

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“…There is the presence of greater number of epitopes in the region of L1 that is conserved and such regions are the prime targets for antibodies (neutralizing types). It can, therefore, be mentioned without a doubt that as far as designing vaccine is concerned a better target is L1 protein compared to L2 ( 86 ). In silico approaches to predict the epitopes are highly valuable compared to conventional procedures that are costly and time-consuming.…”

Section: Hpv Diseasementioning

confidence: 99%

Advances in Designing and Developing Vaccines, Drugs and Therapeutic Approaches to Counter Human Papilloma Virus

Dadar

Chakraborty²,

Dhama

et al. 2018

Front. Immunol.

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Human papillomavirus (HPV) is a viral infection with skin-to-skin based transmission mode. HPV annually caused over 500,000 cancer cases including cervical, anogenital and oropharyngeal cancer among others. HPV vaccination has become a public-health concern, worldwide, to prevent the cases of HPV infections including precancerous lesions, cervical cancers, and genital warts especially in adolescent female and male population by launching national programs with international alliances. Currently, available prophylactic and therapeutic vaccines are expensive to be used in developing countries for vaccination programs. The recent progress in immunotherapy, biotechnology, recombinant DNA technology and molecular biology along with alternative and complementary medicinal systems have paved novel ways and valuable opportunities to design and develop effective prophylactic and therapeutic vaccines, drugs and treatment approach to counter HPV effectively. Exploration and more researches on such advances could result in the gradual reduction in the incidences of HPV cases across the world. The present review presents a current global scenario and futuristic prospects of the advanced prophylactic and therapeutic approaches against HPV along with recent patents coverage of the progress and advances in drugs, vaccines and therapeutic regimens to effectively combat HPV infections and its cancerous conditions.

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Section: Hpv Diseasementioning

confidence: 99%

Advances in Designing and Developing Vaccines, Drugs and Therapeutic Approaches to Counter Human Papilloma Virus

Dadar

Chakraborty²,

Dhama

et al. 2018

Front. Immunol.

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“…L1-VLPs have shown to be immunogenic and able to induce high-titers of protective neutralizing antibodies (nAb), which are triggered by repetitive and tightly spaced epitopes that readily activate B cells via the B cell receptor or toll-like receptor cross-linking. Additionally, L1 is rich in T cell epitopes needed to provide B cell help [ 35 , 36 , 37 ].…”

Section: Licensed Hpv Vaccinesmentioning

confidence: 99%

RG1-VLP and Other L2-Based, Broad-Spectrum HPV Vaccine Candidates

Huber

Wang

Roden

et al. 2021

JCM

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Licensed human papillomavirus (HPV) vaccines contain virus-like particles (VLPs) self-assembled from L1 major-capsid proteins that are remarkably effective prophylactic immunogens. However, the induced type-restricted immune response limits coverage to the included vaccine types, and costly multiplex formulations, restrictive storage and distribution conditions drive the need for next generation HPV vaccines. Vaccine candidates based upon the minor structural protein L2 are particularly promising because conserved N-terminal epitopes induce broadly cross-type neutralizing and protective antibodies. Several strategies to increase the immunological potency of such epitopes are being investigated, including concatemeric multimers, fusion to toll-like receptors ligands or T cell epitopes, as well as immunodominant presentation by different nanoparticle or VLP structures. Several promising L2-based vaccine candidates have reached or will soon enter first-in-man clinical studies. RG1-VLP present the HPV16L2 amino-acid 17–36 conserved neutralization epitope “RG1” repetitively and closely spaced on an immunodominant surface loop of HPV16 L1-VLP and small animal immunizations provide cross-protection against challenge with all medically-significant high-risk and several low-risk HPV types. With a successful current good manufacturing practice (cGMP) campaign and this promising breadth of activity, even encompassing cross-neutralization of several cutaneous HPV types, RG1-VLP are ready for a first-in-human clinical study. This review aims to provide a general overview of these candidates with a special focus on the RG1-VLP vaccine and its road to the clinic.

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“…IEDB web server using some parameters, including Kolaskar-Tongaonkar as the antigenicity scale parameter, which is the standard for epitope prediction [22]. The Kolaskar and Tongaonkar antigenicity scales based on the amino acid residues' physicochemical properties and the known tendency frequency as an experimental epitope have an accuracy of 75% [10].…”

Section: Iedbmentioning

confidence: 99%

In-Silico Approach in the Development of Salmonella Epitope Vaccine

Rachmawati¹,

Nugraheni²,

Sumadi³

2021

Salmonella Spp. - A Global Challenge

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In the case of infection control, one of our primary concerns is typhoid fever. According to WHO, typhoid prevalence in Indonesia is highly endemic. There is also the problem with the low efficacy of the available vaccine to prevent the disease. Therefore, there is an urgent need to develop a highly effective typhoid vaccine. One of the phases in vaccine development is an exploratory phase, a research-intensive phase of the vaccine development process designed to identify natural or synthetic antigens that might help prevent or treat a disease through computer in silico prediction targets. The vaccines developed through epitope peptide are designed to be safer, more efficacious, and less expensive than traditional vaccines. A thorough understanding of the disease agent, particularly critical epitopes to induce the appropriate immunological reaction, is required to achieve these aims. Mapping epitope sequences or antigenic peptides from pathogenic proteins recognized by B cells and T cells is crucial for vaccine development. Once the epitopes were identified, the polypeptide production could be produced through protein recombinant technology. The polypeptide vaccine, in the end, could be delivered using a liposomal delivery system.

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Epitope design of L1 protein for vaccine production against Human Papilloma Virus types 16 and 18

Cited by 10 publications

References 61 publications

Advances in Designing and Developing Vaccines, Drugs and Therapeutic Approaches to Counter Human Papilloma Virus

Advances in Designing and Developing Vaccines, Drugs and Therapeutic Approaches to Counter Human Papilloma Virus

RG1-VLP and Other L2-Based, Broad-Spectrum HPV Vaccine Candidates

In-Silico Approach in the Development of Salmonella Epitope Vaccine

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