Epitheliotropic T-cell gastrointestinal tract lymphosarcoma with metastases to lung and skeletal muscle in a cat

Krecic, Matthew R.; Black, Sharon S.

doi:10.2460/javma.2000.216.524

Cited by 30 publications

(36 citation statements)

References 19 publications

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“…This form of malignant lymphoma has been reported previously in the dog, cat, and cow but has been most extensively studied in humans, where it is classified by the Revised European and American Lymphosarcoma classification system as intestinal Tcell malignant lymphoma, with or without enteropathy (ITCL). [9][10][11][12][13][14][15][16] ITCL is uncommon in humans. It has been documented to occur as a sequela to, or in conjunction with, celiac disease.…”

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confidence: 99%

Feline Epitheliotropic Intestinal Malignant Lymphoma: 10 Cases (1997–2000)

Carreras

Goldschmidt

Lamb³

et al. 2003

Veterinary Internal Medicne

124

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The clinical, histopathologic, and immunohistochemical features of 10 cats with epitheliotropic intestinal malignant lymphoma (EIL) are described. Intestinal biopsy samples were reviewed by 3 pathologists to confirm the diagnosis of EIL. These samples (n = 10) were compared to the intestinal biopsies of normal cats (n = 11), cats with inflammatory bowel disease (IBD; n = 7), and cats with non-EIL (n = 9) for quantification and immunophenotyping of intraepithelial lymphocytes. Immunophenotypic studies were performed with CD3 and CD79a antibody stains to assess for T- and B-cell immunoreactivity, respectively. EIL biopsies had markedly more intraepithelial lymphocytes than normal intestine (NRL) and samples from cats with IBD. However, no marked difference was observed in the number of intraepithelial lymphocytes in cats with non-EIL compared to cats with EIL. Regardless of the histologic diagnosis, the intraepithelial lymphocytes in all cats were small- to intermediate-sized T cells. Clinical findings and imaging studies in the cats identified minimal or nonspecific findings in affected cats. Most cats fit the typical profile of cats with IBD or alimentary malignant lymphoma. Nine of 10 cats with EIL were treated with prednisone with or without additional chemotherapy. Four cats were refractory to chemotherapy and were euthanized within 3.5 months. The remaining 5 cats had long-term survival times of 11 months or greater. The median survival time was 11 months. Additional studies are warranted to better characterize EIL and its relationship to IBD in cats and non-EIL and to identify optimal treatment strategies for this disease.

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confidence: 99%

Feline Epitheliotropic Intestinal Malignant Lymphoma: 10 Cases (1997–2000)

Carreras

Goldschmidt

Lamb³

et al. 2003

Veterinary Internal Medicne

124

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“…Epitheliotropic intestinal T-cell lymphoma has been reported in a cat, 7 5 dogs, 4,9 and humans. 1,5,12 In the cat, the lymphoma was primarily in the intestinal tract, with metastases to the lungs and to skeletal muscle.…”

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confidence: 99%

Primary Epitheliotropic Intestinal T-cell Lymphoma in a Horse

et al. 2002

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Abstract.A 17-year-old Quarterhorse gelding with a clinical diagnosis of protein-losing enteropathy was submitted for necropsy following a 4-5-month duration of weight loss, decreased appetite, and hypoproteinemia. Gross findings included multiple 1-2-cm diameter ulcers on the luminal surfaces of the duodenum and ileum. Histologic examination revealed individual large, round cells infiltrating much of the mucosal epithelium of the duodenum, jejunum, ileum, and colon in addition to multifocal areas of ulceration. Similar round cells infiltrated Brunner's glands and expanded the submucosa beneath the foci of ulceration. Immunohistochemical staining indicated the round cell population was of T-lymphocyte origin. Several features of this equine neoplasm bear similarities to enteropathy-associated T-cell lymphoma in humans.Alimentary lymphoma in the horse is typically characterized by patchy to diffuse mucosal to transmural intestinal thickenings and infiltration of mesenteric lymph nodes. 2,6,8 In many cases, the neoplastic lymphocytes are suspected, but not demonstrated, to be of B-cell origin, presumably originating from gut-associated lymphoid follicles, 2,8 and predominantly infiltrate the lamina propria and submucosa. Herein we report an equine intestinal lymphoma in which neoplastic cells expressed T-cell, but not B-cell, antigens and were most frequently located within mucosal epithelium.A 17-year-old Quarterhorse gelding presented to the referring veterinarian in October 1999 with a 1-2-month history of weight loss and partial anorexia, which was unresponsive to antibiotic therapy, vitamin B complex, deworming, and dental care. Following a thorough clinical workup, the clinical diagnosis was protein-losing enteropathy, most likely due to small intestinal malabsorption and gastric ulceration. Treatment consisted of dexamethasone, omeprazole, and vitamin supplementation. Although the appetite improved over the next month, the horse failed to gain weight. A second glucose absorption curve revealed 27% improvement, and gastroscopy indicated the gastric ulcers had improved. Over an additional 4 weeks, the horse was able to maintain body weight but remained thin. The horse was euthanized after collapsing in the trailer in transit to the University of Illinois College of Veterinary Medicine, Urbana, Illinois.On gross examination, the horse was emaciated, with serious atrophy of pericardial and mesenteric fat. Present within the parenchyma of the right thyroid gland was a 2-ϫ 1.5-ϫ 1-cm ovoid, gray mass, which bulged at the periphery on sectioning. The abdominal cavity contained approximately 15 liters of clear, watery, pale amber fluid. The thoracic cavity contained approximately 5 liters of clear, watery, pale

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“…In cats, the most common radiographic pulmonary pattern was pulmonary masses and/or nodules and a bronchial infiltrate. Metastatic pulmonary nodules have been described in cats with lymphoma 17,18 ; one in a 9‐year‐old, male neutered Abyssinian with epitheliotrophic T‐cell gastrointestinal lymphoma with metastasis to the lung and skeletal muscle. The pulmonary metastasis was classified as a solitary, well‐demarcated mass 17 …”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, reports specifically describing the radiographic appearance of cytologically or histologically confirmed pulmonary lymphoma in the cat and dog are limited to a few individual reports 15–18 . The purpose of this report is to describe the radiographic appearance of confirmed pulmonary lymphoma in 23 cats and dogs.…”

Section: Introductionmentioning

confidence: 97%

“…It has been reported that 29.6–37% of dogs with multicentric lymphoma have abnormal pulmonary infiltrates on thoracic radiographs; however, these reports did not confirm pulmonary involvement and/or specifically describe the radiographic findings 9,11–13 . Pulmonary patterns that have been described in cats and dogs with presumed pulmonary lymphoma are unstructured interstitial, reticulo‐nodular, alveolar, and nodular 12,14–18 . There are no data regarding the prevalence of abnormal pulmonary infiltrates in cats with lymphoma.…”

Section: Introductionmentioning

confidence: 97%

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Radiographic Appearance of Confirmed Pulmonary Lymphoma in Cats and Dogs

Geyer

Reichle

Valdés‐Martínez

et al. 2010

Veterinary Radiology &Amp; Ultrasound

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Herein we describe the thoracic radiographic appearance of confirmed pulmonary lymphoma. Patients with thoracic radiographs and cytologically or histologically confirmed pulmonary lymphoma were sought by contacting American College of Veterinary Radiology members. Seven cats and 16 dogs met the inclusion criteria, ranging in age from 4 to 15 years. Method of diagnosis was via ultrasound-guided cytology (four), surgical biopsy (two), ultrasound-guided biopsy (one), and necropsy (16). Radiographic findings varied but ranged from normal (one) to alveolar (six) and/or unstructured interstitial infiltrates (11), nodules and/or masses (eight), and bronchial infiltrates (four). Additional thoracic radiographic findings included pleural effusion and lymphadenopathy. The results of this evaluation indicate a wide variability in thoracic radiographic abnormalities in cats and dogs with pulmonary lymphoma.

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Epitheliotropic T-cell gastrointestinal tract lymphosarcoma with metastases to lung and skeletal muscle in a cat

Cited by 30 publications

References 19 publications

Feline Epitheliotropic Intestinal Malignant Lymphoma: 10 Cases (1997–2000)

Feline Epitheliotropic Intestinal Malignant Lymphoma: 10 Cases (1997–2000)

Primary Epitheliotropic Intestinal T-cell Lymphoma in a Horse

Radiographic Appearance of Confirmed Pulmonary Lymphoma in Cats and Dogs

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