Epithelioid trophoblastic tumor: Morphological and immunohistochemical study of three lung lesions

Hamazaki, Shuji; Nakamoto, Shu; Okino, Tomoya; Tsukayama, Choutatsu; Mori, Masaharu; Taguch, Kohji; Okada, Shigeru

doi:10.1016/s0046-8177(99)90063-1

Cited by 67 publications

(44 citation statements)

References 7 publications

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“…All previously reported extrauterine ETT included lung, vagina, broad ligament, fallopian tube, gallbladder, paracervix and parametrium, probably originating from uterine trophoblastic disease [6][7][8][9][10][11][12]. Pancreas metastasis in our study, to our knowledge, was the first case reported.…”

Section: Discussionsupporting

confidence: 49%

Epithelioid trophoblastic tumor: a clinicopathological and immunohistochemical study of seven cases

Shi

Wan

et al. 2010

Med Oncol

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The objective of this study is to evaluate the clinicopathological features and immunohistochemical characteristics of epithelioid trophoblastic tumor (ETT). Seven cases of epithelioid trophoblastic tumor treated in the Women's Hospital of Zhejiang University from 2004 September to 2008 December were retrospectively analyzed. Immunohistochemical study was performed. The most common presenting symptom was vaginal bleeding. Four patients had prior evidence of molar pregnancy and three patients presented with metastases. Mean age at diagnosis was 34.7 years. Mean pregnancy interval was 3.39 years. Human chorionic gonadotropin levels were 33.25-174315.5 IU/l. One case died from metastasis in lungs. The remaining six patients survived without recurrence. Immunohistochemistry revealed diffusely positive for CK18, and focally positive for β-hCG, HPL, Mel-CAM (CD146) and inhibin-alpha. Nuclear staining of Ki67 and p63 were seen. The confirmation of epithelioid trophoblastic tumor diagnosis is difficult before surgery. Surgical intervention is the recommended primary treatment.

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Section: Discussionsupporting

confidence: 49%

Epithelioid trophoblastic tumor: a clinicopathological and immunohistochemical study of seven cases

Shi

Wan

et al. 2010

Med Oncol

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“…hydatidiform mole or choriocarcinoma, is seen in 50% of cases with an interval between 1 and 18 years from gestational trophoblastic tumor to presentation with ETT. With the increased reported cases in the literature, a history of prior gestational trophoblastic tumor seems to be present in around 20% of cases and a history of a prior normal pregnancy is reported in around 55% of cases [5,6,7,8]. The interval between prior gestation or gestational trophoblastic tumor and ETT can range from 2 weeks to 30 years [8,9].…”

Section: Discussionmentioning

confidence: 99%

“…It has a higher mitotic count than that seen in most cases of ETT [2]. Immunohistochemical staining for hCG shows a diffuse pattern in contrast to the focal staining in ETT [2,6]. The differentiation between these two entities has important treatment implications.…”

Section: Discussionmentioning

confidence: 99%

Epithelioid Trophoblastic Tumor: Report of Two Cases in Postmenopausal Women with Literature Review and Emphasis on Cytological Findings

Almarzooqi

Al-Safi²,

Al-Jassar³

et al. 2014

Acta Cytologica

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Background: Epithelioid trophoblastic tumor (ETT) is a rare gestational trophoblastic neoplasm of intermediate trophoblasts. It was first described by Shih and Kurman [Am J Surg Pathol 1998;22:1393-1403] who outlined its clinicopathologic characteristics in 14 cases, establishing it as a distinct entity of gestational trophoblastic tumors. It represents 1.39% of all gestational trophoblastic diseases. Most cases are reported in reproductive-age women following a prior gestation with a time interval between 2 weeks and 30 years. ETT is extremely rare in postmenopausal women. It is commonly misdiagnosed as a squamous cell carcinoma (SCC), poorly differentiated carcinoma or another gestational trophoblastic tumor. Limited data is available regarding its cytological features on Pap smears. Cases: We report 2 cases of uterine ETT occurring in postmenopausal women. In both cases, an initial diagnosis of an SCC and a poorly differentiated carcinoma was rendered. We highlight the features of ETT helpful in differentiating it from other mimickers with emphasis on rarely reported cytological features of this neoplasm. Conclusion: ETT is a rare tumor with characteristic cytological features, but is commonly confused with SCC. A high index of suspicion is needed to make the correct diagnosis or to raise the consideration of ETT, especially in cases with an increased β-human chorionic gonadotropin.

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“…Benign lesions comprise EPS and PSNP [1,[4][5][6]. Malignant counterparts, which are rare, are PSTT and ETT [1,[7][8][9]. On the basis of morphology and immunohistochemistry, it is thought that EPS and PSTT are derived from implantation site intermediate trophoblast, whereas PSNP and ETT are derived from chorionic-type intermediate trophoblast [1].…”

Section: Discussionmentioning

confidence: 99%

Postcesarean delivery uterine diffuse intermediate trophoblastic lesion resembling placental site plaque

2009

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Epithelioid trophoblastic tumor: Morphological and immunohistochemical study of three lung lesions

Cited by 67 publications

References 7 publications

Epithelioid trophoblastic tumor: a clinicopathological and immunohistochemical study of seven cases

Epithelioid trophoblastic tumor: a clinicopathological and immunohistochemical study of seven cases

Epithelioid Trophoblastic Tumor: Report of Two Cases in Postmenopausal Women with Literature Review and Emphasis on Cytological Findings

Postcesarean delivery uterine diffuse intermediate trophoblastic lesion resembling placental site plaque

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