Epithelioid leiomyosarcoma of the ovary

Leiomyosarcoma of the ovary associated with leiomyoma of uterus: a case report

“…Presence of moderate to severe cytological atypia with more than 10 mitosis/10 HPF with features of tumour cell necrosis suggestive of malignancy. 4 They have reactivity positive for dermin, vimentin, and actin and negative for cytokeratin, CD34 and S100. 5,7 The differential diagnosis of OLS include fibro sarcomas, spindle cell sarcoma, Krukenberg tumour, mixed Mullerian tumour, undifferentiated carcinoma, GISTGastro-intestinal stromal tumour.…”

“…They originate from hilar smooth muscles, smooth muscles of blood vessels, totipotent stem cells of ovary or metaplasia of ovarian stroma. 4,5 The tumours are usually asymptomatic or present with non-specific symptoms and signs.…”

“…5,7 The differential diagnosis of OLS include fibro sarcomas, spindle cell sarcoma, Krukenberg tumour, mixed Mullerian tumour, undifferentiated carcinoma, GISTGastro-intestinal stromal tumour. 4,8 The classification of ovarian tumours from IFG&O is recommended for staging purpose of these tumours. 4,5 Radical surgery is the treatment of choice for OLS followed by adjuvant chemotherapy or radiotherapy.…”

“…4,8 The classification of ovarian tumours from IFG&O is recommended for staging purpose of these tumours. 4,5 Radical surgery is the treatment of choice for OLS followed by adjuvant chemotherapy or radiotherapy. In most of these patients the disease confers a poorer prognosis with majority dying within 1 year of diagnosis.…”

Prolonged Survival of a Young Female with High Grade Pleomorphic Leiomyosarcoma of Ovary Without Recurrence

“…Pure primary sarcomas originating in the ovary are rare (\1 %), and only a few cases of fibrosarcoma, leiomyosarcoma, angiosarcoma, and other histologic types of sarcoma have been reported [2]. On gross examination, these tumors are found to be similar to any other sarcomas.…”