Epithelioid Hemangioendothelioma of the Lip: Case Report

Abstract

ascular tumors range from benign hemangiomas to fully malignant angiosarcomas .1-4 Epithelioid hemangioendothelioma (EHE) are rare vascular tumors of round to polygonal cells with eosinophilic cytoplasm, intracytoplasmic vacuoles and vesicular nuclei. EHEs were first identified by Weiss and Enzinger in 1982 5 as tumors with an indolent course and a potential for recurrence or metastasis. [5][6][7] EHE has been reported in lungs, liver, skin, larynx, lymph nodes, thyroid, stomach, brain and meninges but occurrence in the head and neck is rare. So far, 33 cases involving head and neck region were reported in Eng- We present a 19-year-old male with one week history of an asymptomatic swelling of his right lower lip. Dermatologic examination revealed a 1.5x2.0 cm in diameter, firm-irregular lesion on the mucosal surface of the right lower lip and the presumptive diagnosis was cheilitis glandularis-granulomatosis. He was referred to ENT clinic for biopsy. Histologically, there was an infiltrative tumor composed of epithelioid cells. Histopathological diagnosis was epithelioid hemangioendothelioma. Based on this clinically unexpected diagnosis, he underwent re-excision and a suprahyoid lymph node dissection that showed a small focus of residual tumor but no lymph node metastasis. Three years follow-up showed no recurrence or metastasis.K Ke ey y W Wo or rd ds s: : Epithelioid hemangioendothelioma; head and neck Ö ÖZ ZE ET T Epi te li o id he man ji o en do tel yo ma (EHE) na dir bir tü mör dür. Epi te li o id hüc re le rin pro li feras yo nu ile ka rak te ri ze dir, bu özel li ği vas kü ler or jin li tü mör le rin dik ka te alın ma ma sı du ru mun da güç lü ğe ne den ol mak ta dır. Bu ya zı da sağ alt du da ğın da bir haf ta dır asemp to ma tik şiş li ği olan 19 ya şın da ki er kek has ta su nul muş tur. Der ma to lo jik mu a ye ne sin de sağ alt du dak mu ko za sın da 1.5x2 cm çap la rın da, sert-ir re gü ler kit le tes pit edil miş ve ön ta nı ola rak çey li tis glan du la ris-gar nü lo mato zis dü şü nü le rek bi yop si ama cı ile KBB po lik li ni ği ne re fe re edil miş tir. Bi yop si ma ter ya li nin in celen me sin de epi te li o id hüc re ler den olu şan in fil tra tif bir tu mör ol du ğu gö rül müş tür ve his to pa to lo jik ola rak epi te li o id he man ji o en do tel yo ma ta nı sı ko nul muş tur. Bu kli nik ola rak bek len me yen ta nı üze-ri ne tek rar ek siz yon ve sup ra hi yo id bo yun di sek si yo nu ya pıl mış tır, re zi dü el tu mör ve ya lenf no du me tas ta zı iz len me miş tir. Has ta nın üç yıl lık iz le min de re kür rens ya da me tas taz gö rül me miş tir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Epitelioid hemanjioendotelyoma, baş ve boyun T Tu ur rk ki is sh h J J R Rh hi in no ol lo og gy y 2 20 01 13 3; ;2 2( (1 1) ): :1 1--4 4