Epithelioid haemangioma (angiolymphoid hyperplasia with eosinophilia) and Kimura's disease in Chinese

Chan, John K. C.; Hui, Pui Wah; Ng, C.S.; Yuen, Nancy; Kung, I. T. M.; Gwi, E.

doi:10.1111/j.1365-2559.1989.tb01622.x

Cited by 126 publications

(49 citation statements)

References 56 publications

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“…However, in Kimura's disease, there is marked serum eosinophilia and hyperimmunoglobulinemia, at the cost of IgE and lymph node involvement. 4,5 In the patient of the present report, it was not possible to find serum eosinophilia or hyperimmunoglobulinemia.…”

Section: Discussioncontrasting

confidence: 56%

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Epithelioid hemangioma of the colon: a case report

Nonose¹,

Priolli²,

Cardinalli³

et al. 2008

Sao Paulo Med. J.

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CONTEXT: Epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia is an uncommon benign vascular neoplasm that is usually located on the face or neck. Exceptionally, it has been described affecting the colon, with only two such cases described in the worldwide literature. The aim here was to present a case of primary epithelioid hemangioma of the sigmoid colon with confirmation by immunohistochemical examination. CASE REPORT: A 37-year-old woman had had a complaint of intermittent abdominal pain for six months. Two months after the condition started, she began to present changes in her intestinal habit, with evacuations containing blood and mucus and a weight loss of 4 kg over this period. At physical examination, a palpable mass was noted in the lower left quadrant of the abdomen. Neoplasia of the colon was clinically suspected and she underwent colonoscopy. This demonstrated the presence of a vegetating sessile lesion of approximately 5 cm in diameter, at a distance of 36 cm from the anal margin. It occupied 80% of the intestinal lumen. A biopsy collected during the examination suggested a diagnosis of neoplasia of vascular origin. After surgical resection, histopathological examination of the resected specimen confirmed the diagnosis of epithelioid hemangioma of the colon, which was backed up by the immunohistochemical panel (factor VIII, Ki-67, CD-34). At present, three years after the surgery, the patient is asymptomatic, she has recovered her normal weight and she has normal findings from control colonoscopy. Despite the rarity of neoplasia of vascular origin, this possibility should be considered in the differential diagnosis for colorectal tumors.

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Section: Discussioncontrasting

confidence: 56%

“…4 In a review of the literature from 1960 onwards, only two cases of primary EH in the colon could be found. 3 Like vascular neoplasia in other locations, vascular tumors in the colon are generally divided into three categories, based on their clinical evolution.…”

Section: Discussionmentioning

confidence: 99%

Epithelioid hemangioma of the colon: a case report

Nonose¹,

Priolli²,

Cardinalli³

et al. 2008

Sao Paulo Med. J.

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“…Because ALHE and KD share many clinical and histopathological features these lesions have repeatedly been confused and the designations used interchangeably. Overwhelming data now indicate that significant differences exist and in general pathology these entities are separated (Urabe et al 1987;Chan et al 1989), but in ophthalmology the original, unifying concept has largely remained unchanged. Even authoritative ophthalmic textbooks currently report ALHE and KD as being one single entity (Rubin & Jakobiec 1994;Jakobiec et al 1996).…”

Section: Discussionmentioning

confidence: 99%

“…Kimura's disease and ALHE share some similarities, but many clinical and histopathological features remain distinctly different (Chan et al 1989). The essential characteristics have been summarised (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Angiolymphoid hyperplasia with eosinophilia should not be confused with Kimura’s disease

Seregard

2001

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To emphasize the differences between angiolymphoid hyperplasia with eosinophilia (ALHE) and Kimura's disease (KD), two entities often confused in the ophthalmic literature. Methods: Case report of a subcutaneous mass in the periocular region of a 45-year old woman and a MEDLINE review of the ophthalmic and non-ophthalmic literature on ALHE and KD. Results: The clinical and histopathological findings of the present case were consistent with ALHE, but not with KD. A survey of the current ophthalmic literature indicates that these two designations are still often used synonymously, despite that non-ophthalmic papers now separate ALHE from KD. Conclusion:The clinical and histopathological features of ALHE are most often distinctly different from KD and these entities should be clearly separated in the ophthalmic literature. Because of the presumed neoplastic origin ALHE has alternatively been termed epitheloid haemangioma and histiocytic haemangioma. Conversely, Kimura's disease (KD) most probably represents an allergic or autoimmune response preferentially occurring in the head and neck region of young Asian males. Because ALHE and KD share many clinical and histopathological features these lesions have repeatedly been confused and the designations used interchangeably. Overwhelming data now indicate that significant differences exist and in general pathology these entities are separated (Urabe et al. 1987;Chan et al. 1989), but in ophthalmology the original, unifying concept has largely remained unchanged. Even authoritative ophthalmic textbooks currently report ALHE and KD as being one single entity (Rubin & Jakobiec 1994;Jakobiec et al. 1996). Only very recently were two cases of periocular KD reported with the purpose to separate this entity from ALHE (Buggage et al. 1999). Herein we present a case of periocular ALHE with features clearly distinguishable from KD in further support of the concept that KD and ALHE are two separate entities. Case ReportA 45-year old Caucasian woman presented with a history of a slowly growing mass over the previous 6-8 months. Examination revealed a palpable mass located immediately superior to the medial part of the left eyebrow. Surgery was performed and a well-circumscribed subcutaneous mass was found. Following complete excision, the specimen was fixed in 4% formaldehyde and submitted for histopathological examination. There have been no signs of recurrence after a follow-up period of 18 months.The mass measured 11¿10¿7 mm in size and was cut in two halves. The cut surface disclosed a central, softer core surrounded by a rim of denser tissue. Both halves were paraffin embedded and routinely processed for light microscopy. Briefly, sections were cut at 4 mm and stained with haematoxylin and eosin, the van Gieson stain for collagen, the periodic acid-Schiff stain and Alcian blue. In addition, sections were immunostained for the CD45 (clone OPD4; product code M0742) and CD20 (clone B-Ly1; product code M0774) markers (Dako, Carpinteria, CA, USA) using the standar...

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“…The nodules can be pruritic and painful with normal overlying skin. 4,8 Other sites of involvement including the oral cavity, axilla, groin, limbs, and trunk have also been described. 9 Two of our cases (1&2) presented with post-auricular swelling, one presented with swelling over upper lip (case 3) and the last case presented with subcutaneous nodule in the preauricular region.…”

Section: Discussionmentioning

confidence: 99%