Epithelioid haemangioendothelioma of the lung in a dog

Motomura, Noboru; Arimura, Takuro; Otagiri, Y.; Kiryu, Keiji; Oka, Teruaki

doi:10.1016/s0021-9975(98)80053-4

Cited by 16 publications

(17 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 Endothelial tumors were classified as hemangiomas, hemangioendotheliomas, and hemangiosarcomas. Although the designation hemangioendothelioma is infrequently used in veterinary pathology, 10,16,26,32,33,52 this category was adopted in the present study to deal with the heterogeneity within this group and assist the correlation between the expression levels of selected proteins and tumor grade. This category includes lesions with microscopic features intermediate between hemangiomas and hemangiosarcomas in terms of cellularity, mitotic activity, presence of well-formed vascular channels, and degree of invasion.…”

Section: Histologic Typing and Immunohistochemical Studiesmentioning

confidence: 99%

Immunohistochemical Evaluation of Vascular Urinary Bladder Tumors from Cows with Enzootic Hematuria

Carvalho¹,

Naydan

Nunes³

et al. 2009

Veterinary Pathology

View full text Add to dashboard Cite

Abstract. Fifty-six endothelial-derived urinary bladder tumor samples collected from 26 animals with bovine enzootic hematuria were selected for immunohistochemical studies. Expression of factor VIII-related antigen (FVIIIra), CD31, muscle-specific actin, uroplakin III (UPIII), and the cell cyclerelated proteins cyclin D1 and p53 was evaluated in hemangiomas, ''hemangioendotheliomas'' (a vascular tumor that histologically is intermediate in appearance between a hemangioma and a conventional hemangiosarcoma), and hemangiosarcomas. Although CD31 expression was seen in all endothelial tumors tested, FVIIIra was not expressed in poorly differentiated endothelial tumor cells from solid areas or in 7 muscle-invasive hemangiosarcomas. Cyclin D1 overexpression was seen in 53% of hemangiomas, 82% of hemangioendotheliomas, and 95% of hemangiosarcomas. P53 immunoreactivity was only seen in muscle-invasive hemangiosarcomas. The UPIII staining pattern, normally very intense on the apical aspect and cytoplasm of superficial urothelial cells, was altered in the urothelium in an estimated 25% of hemangiomas, most hemangioendotheliomas, and most hemangiosarcomas. In conclusion, CD31 is a better marker than FVIIIra in the characterization of bovine endothelial tumors. The cell cycle regulatory pathways involving cyclin D1 and p53 seem to be impaired in endothelial urinary bladder tumors, p53 immunoreactivity positively correlating with enhanced invasion.

show abstract

Section: Histologic Typing and Immunohistochemical Studiesmentioning

confidence: 99%

Immunohistochemical Evaluation of Vascular Urinary Bladder Tumors from Cows with Enzootic Hematuria

Carvalho¹,

Naydan

Nunes³

et al. 2009

Veterinary Pathology

View full text Add to dashboard Cite

show abstract

“…2,5, 13 We report an additional 12 cases of epithelioid variants of endothelial tumors in 8 dogs, 3 horses, and 1 cow that were submitted to the Cornell University College of Veterinary Medicine between 1987 and 2005.…”

mentioning

confidence: 99%

Epithelioid Variant of Hemangioma and Hemangiosarcoma in the Dog, Horse, and Cow

Warren

Summers

2007

Vet Pathol

View full text Add to dashboard Cite

Abstract. Epithelioid hemangiomas, hemangioendotheliomas, and angiosarcomas are well recognized histologic variants of endothelial tumors in humans that in the past have been confused with neoplasms of epithelial or histiocytic origin. We describe 12 epithelioid endothelial vascular tumors in 8 dogs, 3 horses, and 1 cow that share microscopic features with these tumors in humans. Ten tumors were located within the dermis and subcutis, 1 in the gastrocnemius tendon, and 1 in the skeletal muscle of the thigh. Key histologic features were the plump, epithelioid appearance of neoplastic endothelial cells and occasional cytoplasmic vacuolation, which rarely contained a single erythrocyte. Patterns of epithelioid endothelial cell growth ranged from conventional vasoformative structures to glandlike acini and short ducts to solid, sheetlike arrangements. All tumors were positive for endothelial markers: 12/12 (100%) were positive for von Willebrand factor with variable intensity and distribution and 9/9 (100%) were positive for CD31. All 12 were negative for cytokeratin. We subdivided these tumors into epithelioid hemangiomas (n 5 3) and hemangiosarcomas (n 5 9) based on conventional morphologic criteria, growth pattern (invasive or not), and metastasis (known in 1 case at the time of biopsy). Additional follow-up information obtained by a written questionnaire was available for 6/12 (50%) animals and revealed local recurrence in 3 animals (1 epithelioid hemangioma and 2 epithelioid hemangiosarcoma) and regional metastasis in 3 animals (all epithelioid hemangiosarcomas). This series represents a novel group of vascular tumors in domestic animals of which there are only 3 previous cases reported in the veterinary literature.

show abstract

“…While the well-documented vascular variant of HSA usually presents little to no diagnostic difficulty, epithelioid HSA has been previously confused with epithelial and/or histiocytic neoplasms in veterinary and human medicine, in both clinical and pathology settings. 6,8,10 Although the gross findings observed in this dog were consistent with HSA, cytological evidence of epithelioid neoplastic cells noted on impression smears taken from the pulmonary nodules raised the suspicion of a possible disseminated granulomatous disease or epithelial neoplasia. A similar scenario has also been reported previously in a dog with epithelioid HSA mimicking metastatic epithelial prostatic neoplasia.…”

Section: Discussionmentioning

confidence: 58%

“…5 Hemangiosarcoma can vary in its histological appearance, with epithelioid HSA being an uncommon morphologic variant described in dogs, horses, cattle, and humans. [2][3][4][6][7][8]10 Most epithelioid HSAs in veterinary species are reported to affect the integument. 2,10 Including the present case, only 4 cases of canine epithelioid HSA have been diagnosed in the Department of Pathology at the University of Georgia, between 2005 and 2013, with 3 of 4 cases reported to be confined to the skin.…”

Section: Discussionmentioning

confidence: 99%

“…2,10 Including the present case, only 4 cases of canine epithelioid HSA have been diagnosed in the Department of Pathology at the University of Georgia, between 2005 and 2013, with 3 of 4 cases reported to be confined to the skin. Accordingly, there are only a few case reports of epithelioid HSA documenting focal or disseminated extra-cutaneous or visceral involvement, such as lung, tendon, and skeletal muscle, [2][3][4][6][7][8]10 with only 2 cases concurrently involving multiple organs. 3,8 The present case is unique in its visceral and disseminated presentation, with involvement of the spinal cord and concomitant presence of epithelioid and vascular morphologic variants.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Paraparesis in a Golden Retriever

2013

View full text Add to dashboard Cite

A 7-year-old female spayed Golden Retriever dog presented with fever and a 10-day history of neurological signs, including ambulatory paraparesis and pelvic limb ataxia. Neurological examination initially revealed a T3-L3 myelopathy. Thoracic radiographs revealed a diffuse miliary pulmonary pattern. Endotracheal washes and fine-needle aspirates from several organs aimed at identifying a potential infectious agent or neoplastic process were all unsuccessful. Due to worsening of the clinical signs, euthanasia was elected. Necropsy findings included multifocal, pale to dark red, firm nodules infiltrating the lungs, heart, mesentery, pancreas, small intestine, brain, and spinal cord. Cytological examination of impression smears obtained from the pulmonary nodules during necropsy revealed clusters of epithelioid cells admixed with fewer spindle cells, erythrocytes, and scattered leukocytes. Clinical signs and cytological findings initially suggested the possibility of a widespread granulomatous disease or a metastatic epithelial neoplasm as possible clinical differentials in this case. The final diagnosis was based on the gross and histological findings, with confirmation following histochemistry and immunohistochemistry. Keywords canine neoplasia, epithelioid cells, factor VIII, immunohistochemistry History, Clinical, and Pathological FindingsA 7-year-old female spayed Golden Retriever dog was referred to the University of Georgia Veterinary Teaching Hospital with fever and a 10-day history of neurological deficits. Initial neurological examination revealed a T3-L3 myelopathy characterized by progressive paraparesis and symmetrical pelvic limb ataxia, with delayed postural reaction in the pelvic limbs. Thoracic radiographs evidenced a diffuse miliary pulmonary pattern suggestive of fungal pneumonia or metastatic neoplasia. Endotracheal washes and fine-needle aspirates from lungs, liver, spleen, and peripheral lymph nodes were unsuccessful in detecting a potential infectious agent or neoplasia. A complete blood count, chemistry profile, urinalysis, and abdominal ultrasound were also performed and did not reveal any significant changes. Serology and polymerase chain reaction of blood and urine samples were also negative for potential fungal organisms. Euthanasia was elected shortly after presentation due to rapid clinical deterioration, with severe dyspnea, decompensatory hypoxemia, and worsening of neurological signs, which progressed to include a right thoracic limb nerve root signature characterized by a toe-touching lameness. Necropsy findings included multifocal, dark red, firm, 3 to 5 mm in diameter, homogeneous nodules expanding the lungs (Fig. 1), heart, mesentery, pancreas, small intestinal serosa, brain, and cervical and thoracic spinal cord. The pericardial sac contained 25 ml of serosanguineous fluid and was focally adhered to a dark red, firm, 3 cm in diameter, irregular nodule arising from the right auricle (Fig. 2). The myocardium was also infiltrated by similar masses (Fig. 2). Cytological exam...

show abstract

Epithelioid haemangioendothelioma of the lung in a dog

Cited by 16 publications

References 4 publications

Immunohistochemical Evaluation of Vascular Urinary Bladder Tumors from Cows with Enzootic Hematuria

Immunohistochemical Evaluation of Vascular Urinary Bladder Tumors from Cows with Enzootic Hematuria

Epithelioid Variant of Hemangioma and Hemangiosarcoma in the Dog, Horse, and Cow

Paraparesis in a Golden Retriever

Contact Info

Product

Resources

About