Epithelioid angiomatous nodule of the nasal cavity: Report of 2 cases

Wong, Wai Keat; Lím, D.; Ong, Ching Wern

doi:10.1016/j.anl.2015.02.007

Cited by 7 publications

(7 citation statements)

References 11 publications

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“…Only <50 cases of EAN have been reported so far in the literature. 1,2 The present case is the first reported case of EAN in the gastrointestinal tract, with obscure gastrointestinal bleeding. The pathogenesis of EAN is unknown; owing to its brief duration of development, a reactive disorder has been suggested as the underlying cause.…”

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confidence: 69%

An Unusual Cause of Obscure Gastrointestinal Bleeding

Chen

Yen

2016

Gastroenterology

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Question: A 55year-old man without any remarkable medical history was referred to our hospital for obscure gastrointestinal bleeding. For the past 1 month the patient had been experiencing intermittent episodes of passing tarry stools, which required blood transfusion. Upper endoscopy and colonoscopy performed twice revealed negative findings. Furthermore, abdominal computed tomography scanning revealed no significant intraabdominal lesions. The patient denied using nonsteroidal anti-inflammatory drugs or Chinese herbal drugs and had no fever or weight loss. Laboratory analysis revealed normal liver and renal functions. The white blood cell count was well within the normal range; however, the patient had mild anemia (hemoglobin, 6.4/dL; mean corpuscular volume, 99.8). A capsule endoscopy was performed (Figure A, B; Video 1). What were the findings of capsule endoscopy? See the Gastroenterology web site (www.gastrojournal.org) for more information on submitting your favorite image to Clinical Challenges and Images in GI.

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confidence: 69%

An Unusual Cause of Obscure Gastrointestinal Bleeding

Chen

Yen

2016

Gastroenterology

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“…Histologically are constituted by a lobular proliferation of capillaries consisting of endothelial cells, surrounded by pericytes in a loose stroma, which contains numerous inflammatory cells. In the periphery, ulceration is frequent [6,9]. For both, EAN and PG, the treatment consists in simple local excision [5].…”

Section: Discussionmentioning

confidence: 99%

“…Likewise, peripheral counterpart of central lesion, the peripheral ameloblastomas are lesions of indolent behavior and microscopically exhibit the same histopathological subtypes from central lesions [16]. Microscopically, the differentiation of EAN from mimickers is complex and the differential diagnosis should include epithelioid hemangioma (EH), epithelioid hemangioendothelioma (EHE) and epithelioid angiosarcoma (EA) [6]. EH typically appears as a single or multiple nodule on the head and neck region of adult males.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, the head and neck region is considered the most predominant anatomic site [5]. The etiology of EAN is unknown, but its rapid and ultimately self-limited growth suggests that it is probably a reactive or benign process [6]. To date, no EAN case showing recurrence, progression or metastasis has been reported [3].…”

Section: Introductionmentioning

confidence: 99%

“…EAN is regarded as part of the morphologic spectrum of benign and malignant epithelioid vascular proliferations that includes epithelioid hemangioma (EH), epithelioid hemangioendothelioma (EHE) and epithelioid angiossarcoma (EA) [3,6]. Microscopically, EAN is characterized by a solid and clearly circumscribed proliferation of epithelioid cells that may present vacuoles in the cytoplasm, without cellular atypia or pleomorphism, but some degree of typical mitosis can be visualized [7].…”

Section: Introductionmentioning

confidence: 99%

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Immune cell infiltration in gingival epithelioid angiomatous nodule: Case report and immunohistochemical analysis

Ortega

Bufalino

Navarro

et al. 2017

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathol

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Epithelioid angiomatous nodule (EAN) is a rare benign vascular proliferation, regarded as part of the morphologic spectrum of benign and malignant epithelioid vascular lesions. EAN is a rare lesion affecting the oral mucosa and, to date, only three cases have been reported in the English-language literature. We report the second EAN case affecting the gingival mucosa of a 69-year-old female patient. Oral examination revealed an asymptomatic, well-defined nodule exhibiting a smooth and erythematous surface, measuring 0.8 cm in greater diameter. The lesion was fully excised and histopathological study showed a mucosal epithelioid proliferation with solid and organoid growth patterns, and vascular lumens scattered focally throughout the lesion. The large epithelioid cells showed intracytoplasmic vacuoles and vesicular nuclei with prominent nucleoli, surrounding by scarce extravasated erythrocytes. Immunohistochemistry showed positivity for vimentin, ␣-SMA, CD34, focally for D2-40, and Ki-67 was 15%. Noteworthy, numerous immune cells (HLA-DR+/CD68+/CD163+/FXIIIa +) scattered throughout the lesion, were detected. To the best of our knowledge, this is the first report, which highlights the immune cell population, with M2-like phenotype, as an important component of EAN, suggesting the participation on their etiopathogenic mechanisms.

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Mesenchymal Tumors

Franchi¹

2019

Pathology of Sinonasal Tumors and Tumor-Like Lesions

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Epithelioid angiomatous nodule of the nasal cavity: Report of 2 cases

Cited by 7 publications

References 11 publications

An Unusual Cause of Obscure Gastrointestinal Bleeding

An Unusual Cause of Obscure Gastrointestinal Bleeding

Immune cell infiltration in gingival epithelioid angiomatous nodule: Case report and immunohistochemical analysis

Mesenchymal Tumors

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