Epithelial Repair in Recovery From Vitamin a Deficiency

Abstract

The earliest demonstrable effect of vitamin A deficiency in rats t and guinea pigs 2 is upon epithelial structures.The sequences are atrophy of the epithelium concerned and the substitution for it of a stratified keratinizing epithelium identical in appearances in all locations and arising from focal proliferation of basal cells. Since replacement by keratinizing epithelium in many organs has also been found in human infants, 8 in the monkey Macacus rhesus, 4 in the albino mouse, 5 and gross changes point to the same phenomenon in swine, 6 in dogs, ~ in rabbits, s in calves 9 and in the domestic fowl, l°-n 1

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