Epithelial Repair and Expression of TSLP and EGFR in Nasal Polyp Explants.

Uller, Lena; Andersson, Magnus; Yudina, Yulyana; Howarth, PH; Lackie, Peter M.; Persson, C. G. A.

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4952

Cited by 2 publications

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“…In summary, clinical effects together with pharmacological features of anti-asthma drugs demonstrate that TSLP is an important epithelium-derived player in asthma, whereas a role of adenosine is not supported. Increased expression of TSLP in repairing epithelium [83] is further consistent with a pathogenic role of exaggerated epithelial regeneration in asthma.…”

Section: Pathogenesis Of Asthma: Exaggerated Epithelial Regeneration Rather Than Increased Permeability?mentioning

confidence: 55%

“…Several autacoids released from stressed and injured airway epithelium have attracted pharmacological interest. Thymic stromal lymphopoietin (TSLP) is known to be induced by human epithelial cells at rhinoviral infection [80,81] and injury repair [82,83]. Since clinical efficacy of a biologic anti-TSLP drug in exacerbating asthma was demonstrated [84], TSLP now stands out as a drug target.…”

Section: Pathogenesis Of Asthma: Exaggerated Epithelial Regeneration Rather Than Increased Permeability?mentioning

confidence: 99%

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In vivoobservations provide insight into roles of eosinophils and epithelial cells in asthma

Persson

2019

Eur Respir J

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Observationsin vivoin patients, supported by guinea-pigin vivodata, take centre stage in this perspective. Its objective is to highlight dichotomies between asthma features observedin vivoand accepted views involving cell/molecular biology research paradigms. For example, increased bronchial epithelial permeability is now considered a major paradigm and trait of asthma, yet, absorption of inhaled tracers has not been increasedin vivoin asthma. Such maintained barrier function in exudative asthma reflectsin vivoasymmetry of the epithelial lining as barrier between outside and inside world of molecules and cells. In desquamatory asthma, maintained epithelial tightness may be explained byin vivodemonstrations of exceedingly patchy epithelial loss, prompt creation of plasma-derived provisional barriers, and high-speed epithelial regeneration. Acknowledged protein/peptide secretion by epithelial cellsin vitrois contrasted here with a dominant, unidirectional movementin vivoof plasma-derived proteins/peptides (including antimicrobial peptides) to the surface of an intact epithelial lining. Furthermore, longstanding claims that epithelium-produced adenosine is a mediator of asthma are eroded by observationsin vivoin asthmatics. Notions concerning activation/fate of mucosal tissue eosinophils illustrate additional distinctions between accepted views andin vivopatient observations. Finally,in vitro-based paradigms preaching defect epithelial regeneration and increased permeability in pathogenesis of asthma are contrasted with experimentalin vivoobservations of exaggerated epithelial regeneration, which is multipathogenic in its own right. In conclusion, unexpected and challengingin vivoobservations in recent decades underpin novel insights into mucosal mechanisms in asthma.

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Section: Pathogenesis Of Asthma: Exaggerated Epithelial Regeneration Rather Than Increased Permeability?mentioning

confidence: 55%

Section: Pathogenesis Of Asthma: Exaggerated Epithelial Regeneration Rather Than Increased Permeability?mentioning

confidence: 99%

In vivoobservations provide insight into roles of eosinophils and epithelial cells in asthma

Persson

2019

Eur Respir J

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show abstract

“…Beyond participation of all plasma protein systems, molecular pathways involved in the pure epithelial regeneration‐induced effects listed above have not been determined. However, it is expected that IL‐33 as well as TSLP (thymic stromal lymphopoietin) would be released from such stressed epithelium. Together with other factors, these upstream cytokines are thus contender contributors to an asthma‐like state in epithelium‐regenerating airways.…”

Section: Asthma‐like Loss Of Epithelial Cells and Pathogenic Roles Ofmentioning

confidence: 99%

Comment on review article by Kristina Johansson and Henry McSorley

Persson

2019

Pediatric Allergy Immunology

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Epithelial Repair and Expression of TSLP and EGFR in Nasal Polyp Explants.

Cited by 2 publications

References 0 publications

In vivoobservations provide insight into roles of eosinophils and epithelial cells in asthma

In vivoobservations provide insight into roles of eosinophils and epithelial cells in asthma

Comment on review article by Kristina Johansson and Henry McSorley

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