Epithelial-myoepithelial carcinoma of the tongue base: a case for the case-report and review of the literature

Peters, Peter; Repanos, Costa; Earnshaw, James; Stark, Patrick; Burmeister, Bryan; McGuire, Lloyd; Jeavons, Susanne; Coman, William B.

doi:10.1186/1758-3284-2-4

Cited by 27 publications

(16 citation statements)

References 9 publications

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“…Metastatic clear cell renal cell carcinoma is also in the differential. The observation of a distinct biphasic pattern, the clear cell morphology and known preponderance for occurring in the parotid (60-80%) [10], all of which fit with the current case, helped distinguish EMC from the rest, along with the histochemical and immunohistochemical findings. In this case, the negative staining with PAS/diastase and immunoreactivity with S-100 protein and SMA meant that most other diagnoses were excluded.…”

Section: Discussionsupporting

confidence: 79%

A Double-Clear Variant of Epithelial-Myoepithelial Carcinoma of the Parotid Gland

Hussaini

Angel

Speight

et al. 2012

Head and Neck Pathol

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The hallmark of the histology of epithelialmyoepithelial carcinoma (EMC) is the presence of a regular repetitive mixture of bilayered duct-like structures with an outer layer of myoepithelial cells and inner ductal epithelial cells. Clear cell change in the myoepithelial component is common, but clearing of both cell types, giving an impression of a monocellular neoplasm, is rare. A parotid biopsy was received from an 83-year-old male and subject to routine histologic processing for conventional staining and immunohistochemistry. The encapsulated tumour was composed of sheets of PAS/diastase negative clear cells, separated by fibrous septae. The clear myoepithelial cells were positive for S-100 protein, SMA, and p63 and negative for CK19 and surrounded CK19-positive luminal cells. It is important to utilise immunohistochemistry to differentiate this tumour from others with a similar histologic pattern. Information about the behaviour of the double-clear EMC is limited since there are few cases reported.

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Section: Discussionsupporting

confidence: 79%

A Double-Clear Variant of Epithelial-Myoepithelial Carcinoma of the Parotid Gland

Hussaini

Angel

Speight

et al. 2012

Head and Neck Pathol

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“…CMCHNs have been observed in the gingiva, palate and tongue, larynx, parapharynx, nasopharynx, nasal cavity, nasal sinus, lacrimal gland, inferior temporal fossa, etc [17,18]. And literatures reported that approximately 75% of EMC [19,20] originated from the parotid gland, 10% from the submandibular gland, 10-15% from the salivary glands, and the remaining occurred in the palate, maxillary sinus, nasal cavity, trachea, and the root of the tongue. The AdCC accouted for 28% in malignant submandibular gland tumors, making it the most common malignant salivary gland tumor in this region.…”

Section: Discussionmentioning

confidence: 99%

A series Cases study of Carcinomas derived from myoepithelial cells in head and neck regions

Cheng¹,

Rao²,

Qiu³

et al. 2020

Preprint

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Background and Objectives: Carcinomas derived from myoepithelial cells in head and neck regions (CMCHN) are rare. The aim of this study was to demonstrate the clinical behaviors and treatment outcomes of these tumors.Methods: A retrospective review of fifteen CMCHN cases between 2002 and 2019 in a single institution was performed. Results: All of the fifteen patients (100%) underwent primary surgical resection. Eleven patients (73.3%) received conventional postoperative radiotherapy and four (26.7%) received systemic chemotherapy. Consequently, six patients (40%) had frequently recurrence after surgical resection, and seven patients (46.7%) received second or even third operations. Up to the time of last follow-up, only one patient died and the mean survival time was 15.8 years.Conclusions: Currently, complete surgical excision with or without systemic therapy is preferred, but it has limited efficacy on reducing the risk of recurrence. Thus, more effective systemic therapies are required and the researches on the mechanism of CMCHN recurrence should be encouraged.

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“…On histology, epithelial-myoepithelial carcinoma is characterized by the presence of tubules with two distinct types of cells. The main histological features are epithelial cells in the inner layer of the lumen and myoepithelial cells surrounding the outer layer [ 2 , 7 ]. These features are similar to those of intercalated ducts.…”

Section: Discussionmentioning

confidence: 99%

Epithelial-myoepithelial carcinoma arising from the subglottis: a case report and review of the literature

Kee

et al. 2016

J Med Case Reports

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BackgroundEpithelial-myoepithelial carcinoma is an extremely rare disease that usually occurs in the parotid gland but can occur in a variety of sites such as the nasal cavity, paranasal sinus, and base of the tongue.Case presentationWe report a rare case of epithelial-myoepithelial carcinoma, which developed in the subglottic region. A 78-year-old Korean woman visited our hospital complaining of hoarseness, which had developed 1 month previously. Flexible laryngoscopy showed a round mass that blocked approximately 80 % of the tracheal diameter. Complete excision of the mass was carried out under general anesthesia, using a transoral approach. Epithelial-myoepithelial carcinoma was diagnosed following immunohistochemical analysis.ConclusionsWe report a rare case of epithelial-myoepithelial carcinoma that occurred in the subglottic region. To the best of our knowledge, only one other case has been reported since this disease was first identified approximately 40 years ago.

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Epithelial-myoepithelial carcinoma of the tongue base: a case for the case-report and review of the literature

Cited by 27 publications

References 9 publications

A Double-Clear Variant of Epithelial-Myoepithelial Carcinoma of the Parotid Gland

A Double-Clear Variant of Epithelial-Myoepithelial Carcinoma of the Parotid Gland

A series Cases study of Carcinomas derived from myoepithelial cells in head and neck regions

Epithelial-myoepithelial carcinoma arising from the subglottis: a case report and review of the literature

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