Epithelial-myoepithelial carcinoma of the parotid gland, unusual malignancy radiologically simulating a benign lesion: case report

Piscioli, Irene; Morelli, Luca; Falzone, Andrea; Nonno, Franca Del; Neri, Marinella; Rocco, Z. C. Di; Catalucci, Alessia; Donato, Salvatore; Licci, Stefano

doi:10.1186/1477-7800-4-25

Cited by 10 publications

(16 citation statements)

References 13 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The high signal intensity in T2-weighted images is consistent with low-grade malignant salivary gland tumors, although it is not specific to MEC; high-grade salivary gland malignant tumors are reported to show a low signal intensity in T2-weighted images [9,13]. The tumor is enhanced by contrast media with various patterns, either slightly, well, or heterogeneously [3,8,9,13,17,18,21]. Contrast enhancement suggested a physiologically rich blood supply for the tumor, or highly vascularized characteristics of MEC [9].…”

Section: Discussionmentioning

confidence: 83%

“…MEC is unencapsulated, but may be well-defined with a nodular surface [1]. Among the imaging features of the border or margin of the tumor, some reports have revealed smooth and well-defined tumors without invasion of the adjacent fat planes, suggesting benign tumors [3,8,9,13,19], whereas others have reported poorly circumscribed lobular tumors [12,17,21]. The description of the tumor interface has been reported to differ depending on imaging modality: MRI displays the interface more clearly than CT [8].…”

Section: Discussionmentioning

confidence: 99%

“…MEC displays uniform low or intermediate signal intensity in T1-weighted MR images and homogeneous moderately high or slightly nonhomogeneous high signal intensity in T2-weighted images [8,9,13,14,21,22]. The high signal intensity in T2-weighted images is consistent with low-grade malignant salivary gland tumors, although it is not specific to MEC; high-grade salivary gland malignant tumors are reported to show a low signal intensity in T2-weighted images [9,13]. The tumor is enhanced by contrast media with various patterns, either slightly, well, or heterogeneously [3,8,9,13,17,18,21].…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have examined the image features of MEC [3,[5][6][7][8][9][12][13][14][15][16][17][18][19][20][21][22][23], with most reports presenting well-defined, sometimes poorly-defined, and heterogeneous enhanced tumors in computed tomography (CT) and magnetic resonance (MR) images. In tumors involving the bone, bone destruction is often observed [5,6,15].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Imaging features of myoepithelial carcinoma of the mandible with lymph node metastasis

et al. 2009

View full text Add to dashboard Cite

Objectives To demonstrate the imaging characteristics of a patient with myoepithelial carcinoma (MEC) of the mandible accompanied by submandibular lymph node metastases, and to discuss the differential image-based diagnoses. Patients and resultsThe patient was a 57-year-old woman who had suffered from a dull pain in her left lower molar region for 3 months and had an elastic-soft mass in her submandibular region for 2 months. Computed tomography (CT) images showed permeative destruction of the bone trabecula and intermittent absorption of the cortical plates in the left mandible. The bone marrow of this area showed low signal intensity in a T1-weighted magnetic resonance (MR) image, slightly low signal intensity in a T2-weighted image, and marked contrast enhancement. A tumor was confirmed outside the buccal and lingual cortical plates. The left submandibular mass was shown as a well-defined, water-density mass by CT, low signal intensity in the T1-weighted MR image, and markedly high signal intensity in the T2-weighted image. The histopathological diagnosis was MEC of the mandible with submandibular lymph node metastasis. ConclusionsWe demonstrated the imaging characteristics of MEC, showing permeative destruction of the bone trabecula, intermittent absorption of the mandible, and cystic degeneration of the metastatic cervical lymph node.

show abstract

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Imaging features of myoepithelial carcinoma of the mandible with lymph node metastasis

et al. 2009

View full text Add to dashboard Cite

show abstract

“…1 Although the pathological features of EMC have been extensively studied, preoperative diagnostic imaging fi ndings of EMC have been limited. [2][3][4] In the present report, we described the cross-sectional imaging fi ndings, including those of dynamic magnetic resonance imaging (MRI) and 18 F-fl uorodeoxyglucose positron emission tomography (FDG-PET), of two cases of EMC those arose in the parotid gland.…”

Section: Introductionmentioning

confidence: 98%

Epithelial-myoepithelial carcinoma of the parotid gland: correlation of dynamic magnetic resonance imaging, 18F-fluorodeoxyglucose-positron emission tomography, and pathological findings

et al. 2010

View full text Add to dashboard Cite

We encountered two cases of epithelial-myoepithelial carcinoma (EMC), a rare low-grade malignant tumor of the parotid gland. These two EMCs showed similar imaging findings: gradual contrast enhancement on dynamic magnetic resonance imaging (MRI), intense (18)F-fluorodeoxyglucose (FDG) uptake in the solid tumor portion, and little enhancement and little FDG uptake in the hemorrhagic necrotic tumor portion. When a parotid gland tumor shows gradual MRI contrast enhancement and focally intense FDG uptake, EMC should be included in the differential diagnosis.

show abstract

The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland

Lubin

Song

Zafar

et al. 2019

Diagnostic Cytopathology

View full text Add to dashboard Cite

Oncocytic and oncocytoid lesions represent a distinct subset of salivary gland lesions. True oncocytic lesions of the salivary gland are entirely composed of oncocytes. These are characterized by the presence of abundant eosinophilic granules due to the presence of abundant cytoplasmic mitochondria. Oncocytic lesions of the salivary gland include oncocytosis, oncocytoma, and oncocytic carcinoma. In addition to the true oncocytic lesion, there exists another group of salivary gland lesions, which demonstrate cells with abundant and occasionally granular cytoplasm. These are often termed as “oncocytoid” lesions. The recently proposed Milan System for reporting salivary gland cytology clearly states that fine‐needle aspiration specimens representing oncocytic/oncocytoid lesions of salivary gland cannot effectively distinguish between a nonneoplastic lesion, benign and malignant neoplasms. Therefore, most lesions lacking classic cytomorphologic features will be classified under the umbrella diagnostic term of “Salivary Gland Neoplasm of Uncertain Malignant Potential” (SUMP). In this review, we discuss and illustrate key clinicopathologic and radiologic features that can help the practicing cytopathologist narrow down the differential and provide the best management based diagnosis.

show abstract

Epithelial-myoepithelial carcinoma of the parotid gland, unusual malignancy radiologically simulating a benign lesion: case report

Cited by 10 publications

References 13 publications

Imaging features of myoepithelial carcinoma of the mandible with lymph node metastasis

Imaging features of myoepithelial carcinoma of the mandible with lymph node metastasis

Epithelial-myoepithelial carcinoma of the parotid gland: correlation of dynamic magnetic resonance imaging, 18F-fluorodeoxyglucose-positron emission tomography, and pathological findings

The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland

Contact Info

Product

Resources

About