Epithelial-Myoepithelial Carcinoma of the Lung

Sainathan, Sandeep; Pugalenthi, Amudhan; Danovich, Svetlana; Arif, Farzana; Andaz, Shahriyour

doi:10.1177/000313481207800520

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…Myoepithelial carcinoma primarily arises from the salivary glands, rarely from the soft tissue. 9 10 11 12 PMC-L was described for the first time in 1998; therefore, we identified 12 cases in adult patients and 2 in pediatric patients. Treatment of the primary pulmonary myoepithelial carcinoma involves complete surgical resection followed by radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

The First Reported Pediatric Case of Primary Myoepithelial Carcinoma Involving the Whole Lung: Surgical Radical Treatment and Prosthesis Implant

Filisetti

Russo

Pansini

et al. 2020

European J Pediatr Surg Rep

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Primary myoepithelial carcinoma of the lung (PMC-L) arising from the bronchial glands in lower respiratory tract is exceedingly rare. Thus far, few cases in adults and only one in a pediatric patient have been recorded. To our knowledge, this is the first report of PMC-L successfully removed in a child, focusing on the importance of multidisciplinary primary surgery for the treatment of this tumor. A 7-year-old girl was admitted for persistent cough and fever; she was unresponsive to oral antibiotics. Chest radiography showed loss of volume of left lung sustained by almost total atelectasis. After routine clinical investigations, she was referred for computed tomography scan and magnetic resonance imaging that documented the presence of a mass occupying the entire left upper lobe, infiltrating the pulmonary hilum (main bronchus, pulmonary artery, superior pulmonary vein, and pericardium). After multidisciplinary evaluation, the histopathologic diagnosis of PMC-L was established using ultrasonography-guided transthoracic core needle biopsy and bronchoscopic biopsies. She was then subjected to left pneumonectomy under extracorporeal circulation and positioning of a thoracic expander filled with 200 mL of saline solution. The postoperative course was uneventful. With TREP (very Rare Tumor in Pediatric Age) consent radiotherapy was performed (61.2 Gy). At the 10-month follow-up, the patient was alive, breathing normally without any oxygen support, without recurrence of PMC-L or metastasis, and without any chest deformity. To our knowledge, this is the first case where a pediatric patient was successfully operated for PMC-L involving the whole lung. Extracorporeal circulation enabled us to perform radical primary surgery. Prosthesis implant not only maintained normal chest expansion but also allowed focused radiotherapy, thus enabling us to prevent damage to vital organs.

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Section: Discussionmentioning

confidence: 99%

The First Reported Pediatric Case of Primary Myoepithelial Carcinoma Involving the Whole Lung: Surgical Radical Treatment and Prosthesis Implant

Filisetti

Russo

Pansini

et al. 2020

European J Pediatr Surg Rep

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“…Epithelial–myoepithelial tumors are rare neoplasms that occur more commonly in salivary glands, where they represent approximately 0.5% of primary tumors. [ 7 ] The presence of EMC in the salivary gland was first described by Donath et al in 1972. [ 8 ] The tracheobronchial glands are considered to be counterparts of the minor salivary glands in the respiratory tract and can develop similar tumors.…”

Section: Discussionmentioning

confidence: 99%

“…[ 22 – 24 ] Microscopically, it is a multinodular lesion presenting a bicellular pattern of proliferating epithelial cells with eosinophilic centrally located nucleus and myoepithelial cells with abundant clear cytoplasm. [ 7 ] Immunohistochemically, the epithelial component is positive for keratin and carcino-embryonic antigen (CEA), while myoepithelial component is positive for S-100, p63, and CD10. Epithelial cells are positive for TTF-1, unlike myoepithelial cells.…”

Section: Discussionmentioning

confidence: 99%

A rare case of primary peripheral epithelial myoepithelial carcinoma of lung

2016

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Background:Primary salivary gland–type tumors of lung are rare. Epithelial–myoepithelial carcinoma (EMC) of the lung is a minor salivary gland–type tumor subtype.Methods:We report a very rare case of EMC located in the peripheral left lower lobe that was diagnosed in a 58-year-old man and this is the first study in which we summarize all the patients with primary peripheral lung EMC concerned with the clinical features. Informed consent was obtained from the patient.Results:Chest computed tomography displayed an anomalous soft tissue mass with slightly lobular borders in the peripheral segment of the left lower lobe and closed to the visceral pleura. The surgery was performed by using video-assisted thoracic surgery. Grossly, the tumor was solitary, well-circumscribed, and unencapsulated endobronchial lesion. A microscopic examination revealed that it was circumscribed, although the tumor borders may show single cells or clusters of cells proliferating away from the main tumor mass. The inner tubular layer showed epithelial cell characteristics, whereas the outer layer exhibited myoepithelial cell characteristics. Immunostaining for P40, P63, and cytokeratin 5/6 was positive. However, the anaplastic lymphoma kinase-V, thyroid transcription factor-1, synaptophysin, chromogranin A and napsin A were negative.Conclusions:Literature review showed that most of patients with peripheral EMC were asymptomatic. Computed tomography and magnetic resonance imaging scans are able to indicate the presence of peripheral EMC. Pathological analysis is an effective method to clarify the diagnosis. Surgery is a regular treatment method. To facilitate the preoperative diagnosis and avoid the misdiagnosis of such a rare disease, more cases will need to be reported.

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