Epithelial Myoepithelial Carcinoma of Parotid Gland

Chaudhari, Pritee; Kaur, Jaspreet; Nalwa, Aasma; Suri, Vaishali; Bhasker, Suman; Chander, Subhash

doi:10.1007/s12070-016-1025-x

Cited by 8 publications

(9 citation statements)

References 13 publications

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“…According to the imaging assessment in this study, all EMCs had well-demarcated margins and capsules, and a multinodular structure with internal septa was observed in four out of seven (57%) EMCs. Histologically, EMCs generally had well-circumscribed expansile borders and might be encapsulated by a well-defined fibrous capsule [ 9 ]. Our histological investigation revealed fibrous capsules in six lesions (86%), whereas the remaining one (14%) was surrounded by fibrous tissues.…”

Section: Discussionmentioning

confidence: 99%

“…Previous case reports of EMCs described a preoperative diagnosis of pleomorphic adenoma based on fine needle aspiration cytology [ 9 , 24 ]; therefore, its characteristic MRI features may play a complementary role for the diagnosis of EMC. Even if EMC is strongly suspected on MRI, a systemic screening would still be necessary because distant metastasis was observed in 25% of salivary gland EMCs.…”

Section: Discussionmentioning

confidence: 99%

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MRI findings of epithelial–myoepithelial carcinoma of the parotid gland with radiologic–pathologic correlation

et al. 2022

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Purpose This study aimed to describe the MRI findings of epithelial-myoepithelial carcinoma (EMC) of the parotid gland. Materials and methods Seven patients (four males and three females) aged 40–86 years (mean age, 64 years) with histologically proven EMC of the parotid gland who underwent surgical resection after preoperative MRI were enrolled. MRI images were retrospectively reviewed and contrasted with pathological findings. Results Five patients (71%) had predominantly solid lesions, and two (29%) had predominantly cystic lesions. All seven lesions had well-demarcated margins and capsules without the invasion of adjacent structures. The capsules were incomplete in five lesions (71%) and complete in two (29%). Four lesions (57%) exhibited a multinodular structure with internal septa. Cystic components were observed in three lesions (43%). On T1-weighted images, the solid components were frequently homogeneous (5/7, 71%), and demonstrated isointensity in five lesions (71%) and hypointensity in two (29%) relative to the spinal cord. On T2-weighted images, the solid components were usually heterogeneous (6/7, 86%), and demonstrated hyperintensity in five lesions (71%) and isointensity in two (29%) relative to the spinal cord. The mean apparent diffusion coefficient value of the solid components was 0.967 × 10−3 mm2/s. Conclusion Parotid gland EMCs usually appeared as predominantly solid lesions with well-demarcated margins and capsules. A multinodular structure with internal septa was characteristics of EMCs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

MRI findings of epithelial–myoepithelial carcinoma of the parotid gland with radiologic–pathologic correlation

et al. 2022

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“…The surgical resection is the therapy of choice. Some authors describe an adjuvant radiotherapy with 60 Gy/30 fractions for intermediate or high-grade variants 178 179 180 .…”

Section: Rare Diseases Of the Salivary Glandsmentioning

confidence: 99%

“…Die chirurgische Resektion ist die Therapie der Wahl. Einige Autoren beschreiben eine adjuvante Radiotherapie mit 60 Gy/30 Fraktionen für Intermediate- oder High-grade-Varianten 178 179 180 .…”

Section: 621 Epithelial-myoepitheliales Karzinomeunclassified

Seltene Erkrankungen der Speicheldrüsen und des Nervus Facialis

Scherl

2021

Laryngorhinootologie

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ZusammenfassungSpeicheldrüsenerkrankungen sind, insgesamt gesehen eher selten. In der Europäischen Union (EU) gilt eine Erkrankung als selten, wenn nicht mehr als 5 von 10,000 Menschen in der EU von ihr betroffen sind. Allein in Deutschland leben Schätzungen zufolge etwa 4 Millionen Menschen mit einer seltenen Erkrankung, in der gesamten EU geht man von 30 Millionen aus 1. Die meisten in der vorliegenden Arbeit beschriebenen Krankheitsbilder der Speicheldrüsen und des N. facialis fallen unter diese Kategorie. Sie bilden eine sehr heterogene Gruppe, deren Behandlung sich auf spezialisierte Zentren konzentriert. Dennoch ist es für den HNO-Arzt unerlässlich, auch diese seltenen Erkrankungen zu erkennen und zu diagnostizieren, um dann die richtigen therapeutischen Schritte einzuleiten. Die Arbeit ist eine Zusammenstellung des gesamten Spektrums angeborener und erworbener seltener Speicheldrüsen- und N. facialis-Erkrankungen. Dabei werden die Ätiologien entzündlicher Erkrankungen, Autoimmunerkrankungen und Tumoren berücksichtigt. Für die einzelnen Themenkomplexe wurde, soweit vorhanden, die aktuelle Literatur ausgewertet und für den Leser in Fakten zusammengefasst. Dazu wird auf die Entwicklung neuer Verfahren in Diagnostik, Bildgebung und Therapie eingegangen. Auch genetische Hintergründe von Tumorerkrankungen bei Speicheldrüsentumoren und die Trends in der Behandlung tumoröser Läsionen des N. facialis werden aufgegriffen. Des Weiteren werden auch seltene Erkrankungen der Speicheldrüsen im Kindesalter betrachtet. Diese können zwar teilweise auch bei Erwachsenen vorkommen, unterscheiden sich aber doch in Häufigkeit und Symptomatik. Auf Grund der Seltenheit der hier abgehandelten Erkrankungen ist es zu empfehlen, diese in spezialisierten Zentren mit entsprechender Erfahrung zu behandeln. Abschließend werden die Schwierigkeiten der Studiendurchführung und die Problematik der Erstellung von Krankheitsregistern beim Thema Speicheldrüsenerkrankungen besprochen, da diese auf Grund der allgemeinen Seltenheit dieser Pathologien besonders relevant sind.

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“…Clinical and radiological findings along with cytological findings can clinch the diagnosis preoperatively, facilitating adequate patient management. Histopathology and immunohistochemistry (IHC) are required to confirm the diagnosis 2. Due to its varied presentation, it must be differentiated from other benign and inflammatory conditions.…”

Section: Introductionmentioning

confidence: 99%

Epithelial myoepithelial carcinoma of the parotid gland with high-grade transformation

Rani,

Banerjee,

Aggarwal

et al. 2024

BMJ Case Rep

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A woman presented with a painless swelling in front of her right auricle, which, on examination, seemed to be a hard, immobile mass arising from the right parotid gland. CT scan showed a heterogeneously enhancing mass lesion in the superficial lobe of the parotid gland with partial extension into the deep lobe. Fine needle aspiration cytology suggested a high-grade transformation (HGT) with the presence of bizarre tumour cells. She underwent a right-sided total parotidectomy with transient facial neuropraxia in the postoperative period. The final pathological diagnosis of the specimen came out to be epithelial myoepithelial carcinoma with HGT, which is a relatively rare entity, with no defined guidelines for management. Our patient was managed by surgical resection alone without any postoperative radiation therapy, and short-term follow-up results seem to suggest no recurrence.

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Epithelial Myoepithelial Carcinoma of Parotid Gland

Cited by 8 publications

References 13 publications

MRI findings of epithelial–myoepithelial carcinoma of the parotid gland with radiologic–pathologic correlation

MRI findings of epithelial–myoepithelial carcinoma of the parotid gland with radiologic–pathologic correlation

Seltene Erkrankungen der Speicheldrüsen und des Nervus Facialis

Epithelial myoepithelial carcinoma of the parotid gland with high-grade transformation

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