Epithelial–myoepithelial carcinoma of a minor salivary gland in the buccal mucosa

Abstract

Epithelial-myoepithelial carcinoma (EMC) is a rare tumor constituting less than 1 % of all salivary gland tumors. This neoplasm most often involves the parotid glands, with less frequent involvement of the submandibular or minor salivary glands. This case report describes EMC arising from a minor salivary gland in the buccal mucosa. A 71-year-old Japanese man with a painless submucosal mass in the left buccal region was referred to our hospital. The patient stated that the tumor had been present for more than 4 years and was painless but increasing in size. Oral examination showed a mobile, well-defined mass of approximately 19 9 15 mm; its surface was covered mostly by normal mucosa. Magnetic resonance imaging showed a mass with well-defined borders and relative homogeneity internally. Incisional biopsy led to a histological diagnosis of a suspected pleomorphic adenoma or low-grade malignant tumor originating from the salivary gland. The patient underwent surgical excision under general anesthesia to obtain a definitive diagnosis, and EMC was diagnosed based on histopathological and immunohistochemical examination of the whole specimen. Because the surgical margins were positive in some areas, the patient underwent external postoperative radiotherapy (total of 60 Gy at 2 Gy/day). Recovery was uneventful, and good function returned after postoperative treatment. Four years after tumor resection and radiotherapy, no recurrence had been detected and no other lesions had developed.

Epithelial-Myoepithelial Carcinoma of the Minor Salivary Glands: Case Series with Comprehensive Review

“…Of the 38 cases, 18 cases satisfied the above-mentioned inclusion eligibility. The details are summarized in Table 1 [3,[19][20][21][22][23][24][25][26][27][28][29]. The cohort included 10 women and 8 men with a median age of 64 (range: 29-83) years.…”

Epithelial-Myoepithelial Carcinoma on Lower Lip and Microinvasive Verrucous Carcinoma in Vocal Cord: Case Report

“…EMC is a low-grade malignancy, rarely transforms to high-grade or dedifferentiated EMC [4]. It mostly arises in the major salivary glands, the rate of involving minor salivary glands is 5.1%; only one case involved the buccal mucosa [7]. Histopathologically, EMC is characterized by a glandular structure consisting of inner epithelial cells and outer myoepithelial cells.…”

Epithelial-Myoepithelial Carcinoma of The Minor Salivary Glands: Report of Two Cases with Literature Review

“…Of the 38 cases, 18 cases satistied the above-mentioned inclusion eligibility. The details are summarized in Table 1 [3,[19][20][21][22][23][24][25][26][27][28][29]. The cohort included 10 women and 8 men with a median age of 64 (range: 29-83) years.…”