Epithelial-myoepithelial carcinoma: a population-based survival analysis

Gore, Mitchell R.

doi:10.1186/s12901-018-0063-2

Cited by 34 publications

(44 citation statements)

References 5 publications

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“…EMC arise most commonly in the parotid (75%) and submandibular gland (10%–12%) . Other sites include minor salivary glands, oral cavity, upper and lower airways, lung, breast, skin, soft tissue and gynecological tract . Sublingual and lacrimal glands are exceptional locations .…”

Section: Discussionmentioning

confidence: 99%

Primary epithelial‐myoepithelial carcinoma of the pituitary gland

et al. 2020

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Primary salivary gland‐like tumors of the sella are rare and often challenging to diagnose. They reportedly derive from serous and mucinous glands that remain trapped in the infundibulum during embryogenesis. We report a 68‐year‐old man who presented with partial left third cranial nerve palsy, visual loss in the left eye without visual field defects, headache, weight loss and reduced muscle bulk. Neuroimaging studies demonstrated a solid and cystic, avidly enhancing lesion expanding the pituitary fossa and extending to the left cavernous sinus. The patient underwent craniotomy and the tissue removed showed features of epithelial‐myoepithelial carcinoma similar to the salivary gland, skin and breast counterpart. No primary tumor was found outside the sella. The lesion behaved aggressively despite radio‐chemotherapy and the patient died 22 months from the onset. The tumor showed a novel TP53 in‐frame deletion (Gly154del) while no variants were found in H‐RAS hotspot regions (codons 12, 13 and 61). Our report expands the spectrum of salivary gland‐like tumors primarily occurring in the sella and emphasizes the need for specialist review of rare, non‐neuroendocrine tumors of the pituitary and sella regions.

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Section: Discussionmentioning

confidence: 99%

Primary epithelial‐myoepithelial carcinoma of the pituitary gland

et al. 2020

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“…More specifically, the inner layer of ductal-lining exhibits characteristics of epithelial-type cells while the outer layer exhibits characteristics of clear, myoepithelial type cells. In this tumor, local recurrence rates is ranging from 23% to 80%, an incidence of metastasis is reported to be about 14% and a death rate is reported to be as high as 40% in literature [9]. BCAC has characteristics of basaloid cell proliferation similar to basal cell adenoma (BCA), but is different from BCA in that it exhibits necrosis or mitoses, as well as invasive activity such as capsular invasion.…”

Section: Discussionmentioning

confidence: 99%

Metachronous malignant tumors in ipsilateral salivary glands

Kwon¹,

Kim²,

Rhie³

et al. 2019

Arch Craniofac Surg

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Salivary gland tumors usually appear in solitary mass in single salivary gland. The coexistence of tumors with different histological types occurring within a unilateral parotid gland is an extremely rare event. We experienced a case which two different types of malignant tumors developed at different time points in same gland; metachronous tumors. The second tumor was excised widely and reconstruction was performed by free tissue transfer. Sensory and motor nerve to the left cheek appeared to be intact, and circulation was adequate. This rare case was presented in this article.

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“…A large study by Mitchell Gore analyzing 468 cases of epithelial-myoepithelial carcinoma between 1973-2014 provided valuable population-based survival analysis [5]. These data included mean survival rate of epithelialmyoepithelial carcinoma (Table 1), most common sites of occurance of epithelial-myoepithelial carcinoma (Table 2), epithlial-myoepithelial carcinoma occurrence by sex (Table 3), and epithelial-myoepithelial occurrence by race (Table 4).…”

Section: Discussionmentioning

confidence: 99%

“…Madhura Mahapatra -Conception of the work, Design of the work, Acquisition of data, Analysis of data, Interpretation of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved Mean survival time noted to be 165.5 months [5].…”

Section: Author Contributionsmentioning

confidence: 99%