Epithelial–Mesenchymal Transition in Liver Fluke-Induced Cholangiocarcinoma

Sawanyawisuth, Kanlayanee; Sashida, Goro; Sheng, Guojun

doi:10.3390/cancers13040791

Cited by 6 publications

(7 citation statements)

References 47 publications

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“…However, Thailand has the highest incidence rate of liver cancer among metachronous cancer types, which is related to their eating habits. They like to eat sashimi, which leads to infection caused by parasitic liver flukes, resulting in a higher incidence of liver cancer than other cancer types[ 22 ]. On the other hand, we have less data on liver cancer because there are more cases of metastasis of other cancer species in the liver, so it was not included in the study.…”

Section: Discussionmentioning

confidence: 99%

High incidence combination of multiple primary malignant tumors of the digestive system

Yang¹,

Zhang²,

Xue³

et al. 2022

World J Gastroenterol

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BACKGROUND Clinical reports of multiple primary malignant tumors (MPMTs) in the digestive system are increasing. In China, although the survival rate of patients with MPMTs is increasing, the quality of life is very low. Many patients have reached the advanced stage when the second primary tumor is found, resulting in no early intervention and treatment. This is due to the misunderstanding of MPMTs by clinicians, who treat such tumors as metastases. Therefore, before a patient has a second primary tumor, doctors should understand some common combinations of digestive system MPMTs to provide clinical guidance to the patient. AIM To explore the high incidence combination of digestive system MPMTs under heterochronism and synchronization. METHODS A total of 1902 patients with MPMTs at Peking Union Medical College Hospital were analyzed retrospectively. They were divided into metachronous MPMT and synchronous MPMT groups, and then the high incidence combinations of the first primary cancer and the second primary cancer in metachronous cancer and synchronous cancer were sorted. Sex and age differences between metachronous and synchronous tumors were tested by the chi square test and t test, respectively. A P value < 0.05 was considered as statistically significant, and SPSS version 26.0 (SPSS Inc., Chicago, Illinois, United States) was used for statistical analysis. RESULTS Among the 1902 patients with MPMTs confirmed by pathology, 1811 (95.2%) cases were secondary primary cancers, 89 (4.7%) cases were tertiary primary cancers, and 2 (0.1%) cases were quaternary primary cancers. Most (88.2%) of the secondary primary cancers were identified as metachronous multiple primary cancers six months after diagnosis of the first primary cancer. The top ten most common MPMTs in the first primary cancer group ranged from high to low as follows: Breast cancer, thyroid cancer, nonuterine cancer, lung cancer, colon cancer, kidney cancer, uterine cancer, bladder cancer, rectal cancer, and gastric cancer. The highest incidence rate of the first primary cancer in male metachronous cancer was lung cancer (11.6%), the highest incidence rate of the second primary cancer was still lung cancer (24.9%), the highest incidence rate of the first primary cancer in female metachronous cancer was breast cancer (32.7%), and the highest incidence rate of the second primary cancer was lung cancer (20.8%). Among them, breast cancer, nonuterine cancer and uterine cancer were female-specific malignant tumor types, and thyroid cancer also accounted for 79.6% of female patients. The top five metachronous cancer combinations, independent of female-specific malignant tumor types and thyroid cancer, were colon cancer and lung cancer (26 cases), kidney cancer and lung cancer (25 cases), rectal cancer and lung cancer (20 cases), gastric cancer and lung cancer (17 cases), and bladder cancer and lung cance...

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Section: Discussionmentioning

confidence: 99%

High incidence combination of multiple primary malignant tumors of the digestive system

Yang¹,

Zhang²,

Xue³

et al. 2022

World J Gastroenterol

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“…Smad2/3 and Smad4 form a trimeric complex as transcription factors that participate in regulating the expression of EMT-related genes (12), inhibiting E-cadherin synthesis, promoting the expression of interstitial cytokines, such as Vimentin and N-cadherin, reducing cell polarity, weakening epithelial features of tumor cells and enhancing interstitial features, all of which are promoters of tumor invasion and metastasis (13). EMT is also common in cholangiocarcinoma with high invasiveness and recurrence (14)(15)(16). The role of ETV4 in ICC cells and its connection to EMT warrants additional investigation.…”

Section: Biological Effect Of Etv4 and The Underlying Mechanism Of It...mentioning

confidence: 99%

Biological effect of ETV4 and the underlying mechanism of its regulatory effect on epithelial‑mesenchymal transition in intrahepatic cholangiocarcinoma cells

Liu,

Feng,

Xiang

et al. 2024

Oncol Lett

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Intrahepatic cholangiocarcinoma (ICC) is a highly invasive malignant tumor. The prognosis of patients with ICC after radical surgical resection remains poor, due to local infiltration, distant metastasis, a high recurrence rate and lack of effective treatment strategies. E26 transformation-specific sequence variant 4 (ETV4) is a pro-carcinogenic factor that is upregulated in several tumors; however, the role of ETV4 in ICC is relatively unknown.

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“…DNA damage and oncogenesis are presumed to be caused by the continuous cell division involved with tissue injury that is mechanically driven in the presence of external co-factors. The wound - healing reaction apparently causes cell proliferation, which, as in existence of co-factors, considerably aids in the growth of cancer ( Sripa et al ., 2018b , Sawanyawisuth et al ., 2021 ).…”

Section: Pathogenesis Of O Viverrini Induced Chola...mentioning

confidence: 99%

Fish and Food-Fatale: Food-borne Trematode Opisthorchis viverrini and Cholangiocarcinoma

Tan,

Machrumnizar

2023

Helminthologia

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Summary Neglected Tropical Diseases (NTDs) are a group of communicable diseases with a long history with human beings. NTDs are the proxy of poverty since they affect those in low-income and extreme-poverty populations, as those populations lack access to proper health care, clean water, sanitary conditions, and hygiene. NTDs create losses for a nation that come from the health and the economic sectors as well since the costs of diagnosis, prevention, and treatment strain the national purse strings. One of the 20 different forms of NTDs on the list is food-borne trematodes, comprises of Fasciola, Paragonimus, Clonorchis, and Opisthorchis. Currently, it is estimated that food-borne trematodes can cause a devastating effect on mortality and morbidity. All of them are zoonotic, as humans become infected by ingestion of a second intermediate host, such as freshwater snails, fish, or water vegetables. Opisthorchis viverrini, one of the food-borne trematodes that can be found mostly in South East Asia regions, especially in the Mekong basin, is regarded as a group 1 carcinogen leading to cholangiocarcinoma (CCA). This study aims to present the updated review of Opisthorchis viverrini and CCA.

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Epithelial–Mesenchymal Transition in Liver Fluke-Induced Cholangiocarcinoma

Cited by 6 publications

References 47 publications

High incidence combination of multiple primary malignant tumors of the digestive system

High incidence combination of multiple primary malignant tumors of the digestive system

Biological effect of ETV4 and the underlying mechanism of its regulatory effect on epithelial‑mesenchymal transition in intrahepatic cholangiocarcinoma cells

Fish and Food-Fatale: Food-borne Trematode Opisthorchis viverrini and Cholangiocarcinoma

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