Epithelial Mesenchymal Transition in Cancer Progression: Prev entive Phytochemicals

Illam, Soorya Parathodi; Narayanankutty, Arunaksharan; Mathew, S.; Valsalakumari, Remya; Jacob, Rosemol M; Raghavamenon, Achuthan C.

doi:10.2174/1574892812666170424150407

Cited by 34 publications

(23 citation statements)

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“…It is generally agreed that simple polyphenolics are readily absorbed by the intestinal tract . Moreover, in most studies, microgram quantities of individual polyphenols have been shown to exert varied biological effects . It is thus possible that the reversal of hepatosteatosis in VCO‐treated rats could be partially due to its polyphenol content.…”

Section: Discussionmentioning

confidence: 99%

Virgin coconut oil reverses hepatic steatosis by restoring redox homeostasis and lipid metabolism in male Wistar rats

Narayanankutty

Palliyil

Kuruvilla³

et al. 2017

J Sci Food Agric

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Section: Discussionmentioning

confidence: 99%

Virgin coconut oil reverses hepatic steatosis by restoring redox homeostasis and lipid metabolism in male Wistar rats

Narayanankutty

Palliyil

Kuruvilla³

et al. 2017

J Sci Food Agric

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“…GA inhibits the expression of invasion-and EMT-related molecules in HepG2 cells. Epithelial-mesenchymal transition (EMT), which endows tumor cells with enhanced motility and invasion capacities, is a prerequisite for tumor infiltration and metastasis (21). In order to investigate the effect of GA on the expression of invasion-related genes (MMP-2 and MMP-9) and EMT-related genes (E-cadherin, ZO-1, vimentin and N-cadherin), HepG2 cells were treated with GA (25 and 50 µM) for 24 h and then the total cell RNA was extracted and subjected to RT-qPCR analysis.…”

Section: Ga Suppresses the Proliferation Migration And Invasion Abilmentioning

confidence: 99%

Ginkgolic acid suppresses the invasion of HepG2 cells via downregulation of HGF/c‑Met signaling

Meng

Zhang

et al. 2018

Oncol Rep

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Liver cancer is one of the most devastating types of cancer worldwide. Despite years of improvements in treatment, the prognosis of patients with this type of malignancy remains poor due to frequent recurrence and metastasis after surgical resection. Ginkgolic acid (GA) is a botanical drug extracted from the seed coat of Ginkgo biloba L. that possesses a wide range of bioactive properties. However, to the best of our knowledge, whether GA can inhibit the invasion of liver cancer cells and the underlying mechanisms remains unknown. The aim of the present study was to investigate the effects of GA on the migration and invasion abilities of liver cancer cells and the underlying molecular mechanism. The results revealed that GA suppressed the migration and invasion abilities of HepG2 cells. In addition, GA treatment inhibited the expression of invasion-related molecules (MMP-2 and MMP-9) and prevented the epithelial-mesenchymal transition (EMT) of HepG2 cells. Further experiments revealed that GA-reduced hepatocyte growth factor (HGF) production and suppressed c-Met phosphorylation may be the underlying mechanisms. Exogenous recombinant HGF supplementation improved the cell invasion ability impaired by GA. Moreover, the in vivo experiment revealed that GA inhibited the tumor growth of liver cancer and prevented EMT. Collectively, these data indicated that GA effectively suppressed the invasion and EMT of HepG2 cells via downregulation of HGF/c-Met signaling, thus GA may serve as a novel chemotherapeutic agent for the

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“…3D). In addition, epithelial-mesenchymal transformation (EMT) plays an important role in the occurrence, development and metastasis of tumors [28,29]. Key transcription factors, including E-cadherin, Ncadherin and vimentin, are extensively involved in the regulation of the EMT process [30].…”

Section: Liquiritin Inhibits Migration and Invasion Of Colorectal Canmentioning

confidence: 99%

Liquiritin represses proliferation , migration and invasion of colorectal cancer cells through inhibition of the miR-671/HOXB3 signaling pathway

Liu

Zhang

Bao

et al. 2020

Preprint

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Background: Colorectal cancer is a common malignant tumor and ranks third in cancer-related deaths. Considering that the side-effects of current therapies limit the clinical effectiveness, exploring new anti-colorectal cancer drugs from natural products is critical for the treatment of colorectal cancer. Among these drugs, liquiritin is an active component of the traditional Chinese herb Glycyrrhiza Radix and has been found to possess powerful anti-inflammatory and anti-tumor abilities. However, the direct molecular target of liquiritin remains unknown. Therefore, the aim of the present study was to identify potential molecular target of liquiritin to mediate its anti-colorectal cancer effect. Methods: The function of liquiritin in cell proliferation, apoptosis, migration and invasion was estimated by CCK-8 assay, colony formation, EdU assay, flow cytometry analysis, TUNEL assay, wound healing assay and transwell assay, respectively. Animal experiment was carried out to further confirm the role of liquiritin in vivo. H&E staining analysis, TUNEL staining and immunohistochemistry (IHC) assay were adopted for histological analysis. The mechanism research was conducted with RT-qPCR, western blot and luciferase report assay. Results: In this study, we found that liquiritin significantly inhibited the proliferation, migration, invasion and EMT processes of SW480 and HT-29 cells in a dose-dependent manner. MiRNAs have been extensively identified as drug targets in various studies. However, the miRNAs functioning as the direct targets of liquiritin remain unknown. In our study, we tested 8 potential pathogenic miRNAs screened from colorectal cancer patients, and we found that only the expression level of miR-671 was diminished due to liquiritin treatment. More importantly, overexpression of miR-671 partially abrogated the anti-tumor effects of liquiritin on colorectal cancer. Conclusions: Collectively, our findings demonstrated that liquiritin exhibits great potential in the treatment of colorectal cancer through regulation of miR-671.

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Epithelial Mesenchymal Transition in Cancer Progression: Prev entive Phytochemicals

Cited by 34 publications

References 0 publications

Virgin coconut oil reverses hepatic steatosis by restoring redox homeostasis and lipid metabolism in male Wistar rats

Virgin coconut oil reverses hepatic steatosis by restoring redox homeostasis and lipid metabolism in male Wistar rats

Ginkgolic acid suppresses the invasion of HepG2 cells via downregulation of HGF/c‑Met signaling

Liquiritin represses proliferation , migration and invasion of colorectal cancer cells through inhibition of the miR-671/HOXB3 signaling pathway

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