Epithelial‐mesenchymal transition and microRNAs: Challenges and future perspectives in oral cancer

Domingues, Cátia; Serambeque, Beatriz; Laranjo, Mafalda; Marto, Carlos Miguel; Veiga, Francisco; Ribeiro, Ana Bela Sarmento; Figueiras, Ana; Botelho, Maria Filomena; Dourado, Marı́lia

doi:10.1002/hed.25381

Cited by 26 publications

(20 citation statements)

References 68 publications

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“…The angiogenesis of tumors can be controlled by miRNAs such as miR-210 and miR-519c under hypoxic conditions via modulating Hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) 78 . Regulatory networks of miRNAs are considered to be a characteristic of epithelial-mesenchymal transition (EMT) in the physiopathology of OSCC 79 . An aggressive phenotype of colorectal cancer (CRC) is significantly associated with depression of miR-29b, whose existence restricts the development and incursion of cancer cells, with the potential interaction of interferon-γ (IFN-γ), IRF1, and IGF1 80 .…”

Section: Biological Functions Of Mirna In Cancermentioning

confidence: 99%

miRNA-based biomarkers, therapies, and resistance in Cancer

et al. 2020

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MicroRNAs (miRNAs), small non-coding RNAs (ncRNAs) of about 22 nucleotides in size, play important roles in gene regulation, and their dysregulation is implicated in human diseases including cancer. A variety of miRNAs could take roles in the cancer progression, participate in the process of tumor immune, and function with miRNA sponges. During the last two decades, the connection between miRNAs and various cancers has been widely researched. Based on evidence about miRNA, numerous potential cancer biomarkers for the diagnosis and prognosis have been put forward, providing a new perspective on cancer screening. Besides, there are several miRNA-based therapies among different cancers being conducted, advanced treatments such as the combination of synergistic strategies and the use of complementary miRNAs provide significant clinical benefits to cancer patients potentially. Furthermore, it is demonstrated that many miRNAs are engaged in the resistance of cancer therapies with their complex underlying regulatory mechanisms, whose comprehensive cognition can help clinicians and improve patient prognosis. With the belief that studies about miRNAs in human cancer would have great clinical implications, we attempt to summarize the current situation and potential development prospects in this review.

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Section: Biological Functions Of Mirna In Cancermentioning

confidence: 99%

miRNA-based biomarkers, therapies, and resistance in Cancer

et al. 2020

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“…Cancer malignant progression is determined by both endogenous changes of oncogenes and/or suppressors, and its surrounding tumor microenvironment (TME) . In the aspect of cancer cells, EMT is a complicated reprogramming process, which is characterized by the inhibition of epithelial markers and upregulation of mesenchymal markers . Therefore, we used multiple methods to evaluate the effects of miR‐30e‐5p on the alterations of EMT markers.…”

Section: Resultsmentioning

confidence: 99%

“…It is well established that miRNA play key roles in diverse biopathological behaviors, including malignant growth, metastasis and resistance to chemotherapy and radiotherapy . Abundant studies have shown that miRNA are dysregulated in numerous cancers, including SCCHN, contributing to cancer progression . Therefore, modulation of specific miRNA activities represents a potential therapeutic avenue …”

Section: Introductionmentioning

confidence: 99%

miR‐30e‐5p represses angiogenesis and metastasis by directly targeting AEG‐1 in squamous cell carcinoma of the head and neck

Zhang

Liu

et al. 2019

Cancer Science

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Metastasis is a critical determinant for the treatment strategy and prognosis in patients with squamous cell carcinoma of the head and neck (SCCHN). However, the mechanisms underlying SCCHN metastasis are poorly understood. Our study sought to determine the key microRNA and their functional mechanisms involved in SCCHN metastasis. For The Cancer Genome Atlas (TCGA) data analysis, quantitative PCR was used to quantify the level of miR-30e-5p in SCCHN and its clinical significance was further analyzed. A series of in vitro and in vivo experiments were applied to determine the effects of miR-30e-5p and its target AEG-1 on SCCHN metastasis. A mechanism investigation further revealed that AEG-1 was implicated in the angiogenesis and metastasis mediated by miR-30e-5p. Overall, our study confirms that miR-30e-5p is a valuable predictive biomarker and potential therapeutic target in SCCHN metastasis. K E Y W O R D SAEG-1, angiogenesis, metastasis, miR-30e-5p, squamous cell carcinoma of the head and neck

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“…Oral squamous cell carcinoma (OSCC) is the most common epithelial cancer of the head and neck [37,38]. OSCC is highly malignant and prone to local invasion and cervical lymph node metastasis, causing facial deformity, speech and esthetic disorders and leading to low survival rate and poor quality of life [38].…”

Section: Exosomes In Oral Squamous Cell Carcinomamentioning

confidence: 99%

Emerging functions and clinical applications of exosomes in human oral diseases

2020

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Exosomes are cell-derived membranous vesicles of endosomal origin secreted by all type of cells and present in various body fluids. Exosomes are enriched in peptides, lipids, and nucleic acids, emerging as vital modulators in intercellular communication. Exosomes are increasingly being evaluated as biomarkers for diagnosis and prognosis of diseases, because the constituents of exosomes could be reprogrammed depending on the states of diseases. These features also make exosomes a research hotspot in oral diseases in recent years. In this review, we outlined the characteristics of exosomes, focused on the differential expressions and altered biological functions of exosomes in oral diseases, including oral squamous cell carcinoma, oral leukoplakia, periodontitis, primary Sjögren's syndrome, oral lichen planus, as well as hand foot and mouth disease. Besides, accumulated evidence documents that it is implementable to consider the natural nanostructured exosomes as a new strategy for disease treatment. Herein, we highlighted the therapeutic potential of exosomes in oral tissue regeneration, oncotherapy, wound healing, and their superiority as therapeutic drug delivery vehicles.

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Epithelial‐mesenchymal transition and microRNAs: Challenges and future perspectives in oral cancer

Abstract: Therefore, we propose that targeting therapies to epithelial-mesenchymal transition-type cells, namely, coordinating microRNAs and/or hydrophobic drugs, such as conventional therapy, could be a promising strategy to improve the outcomes of patients with OSCC.

Cited by 26 publications

References 68 publications

miRNA-based biomarkers, therapies, and resistance in Cancer

miRNA-based biomarkers, therapies, and resistance in Cancer

miR‐30e‐5p represses angiogenesis and metastasis by directly targeting AEG‐1 in squamous cell carcinoma of the head and neck

Emerging functions and clinical applications of exosomes in human oral diseases

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