Epithelial Inclusion Cyst in Conjunctival Melanoma

Abstract

Conjunctival melanoma is the second most common conjunctival malignancy. Its differential diagnosis with other conjunctival melanocytic neoplasms is inherently difficult. The presence of epithelial cysts is a useful feature in conjunctival tumors and favors a benign lesion. Herein 2 cases of conjunctival melanoma with cysts are presented. To the best of our knowledge, this is the first series of conjunctival melanoma with epithelial inclusion cysts. This series emphasizes the importance of considering several malignant features when reviewing conjunctival melanocytic lesions, as malignancy can exist even in the presence of epithelial inclusion cysts.

Giant Conjunctival Nevus in a 12-Year-Old Child

“…Epithelial cell-walled intralesional cysts are the “memory” of epithelial origin in conjunctival nevi; therefore they can be considered as signs of chronicity suggesting benign nature of the lesion [ 1 , 2 ]. Intralesional cysts can be rarely seen in conjunctival melanoma although malignant melanoma arising from preexisting cystic nevi can feature intralesional cysts [ 6 ]. AS-OCT examination proved to be a very informative tool in the diagnosis of conjunctival nevi [ 7 ].…”