Epithelial Hyperplasia of the Breast: Comparison of Incidence between Cases of Breast Carcinoma and Control Autopsy Specimens with Immunohistochemical Observation of Blood Group Antigens

Inai, Kei; Yamamoto, Atsushi; Arihiro, Koji; Khatun, Nasima; Kurihara, Kanji; Takeda, Shinpei

doi:10.1111/j.1440-1827.1992.tb01671.x

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…A further 10 potential papers were identified from the references and forward citation searches of the 10 included papers; of these 3 studies were included, with one [ 25 ] contributing two datasets (studies performed in two different countries). A total of 13 studies [ 25 – 37 ], contributing 14 datasets were included in the study level analysis, Table 1 . There were 2363 women and 99 cases.…”

Section: Resultsmentioning

confidence: 99%

“…2 a : Cancer or precursor lesion 2 b : Invasive cancer 2 c : In-situ cancer 2 d : Atypical Hyperplasia. Data points are proportional to total number of women in each study and are numbered according to year of study as follows: 1: Kiaer [ 26 ], 2: Ryan [ 27 ]; 3: Sarnelli [ 28 ]; 4: Kramer [ 29 ]; 5: Nielsen 1984 [ 30 ]; 6: Bartow [ 31 ]; 7: Nielsen 1987 [ 32 ]; 8: Alpers [ 33 ]; 9: Pisano [ 34 ]; 10: Bhathal [ 35 ]; 11: Giarelli [ 36 ]; 12: Inai [ 37 ]; 13: Stalsberg (Ghana) [ 25 ]; 14: Stalsberg (Norway) [ 25 ] …”

Section: Resultsmentioning

confidence: 99%

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Prevalence of incidental breast cancer and precursor lesions in autopsy studies: a systematic review and meta-analysis

et al. 2017

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BackgroundAutopsy studies demonstrate the prevalence pool of incidental breast cancer in the population, but estimates are uncertain due to small numbers in any primary study. We aimed to conduct a systematic review of autopsy studies to estimate the prevalence of incidental breast cancer and precursors.MethodsRelevant articles were identified through searching PubMed and Embase from inception up to April 2016, and backward and forward citations. We included autopsy studies of women with no history of breast pathology, which included systematic histological examination of at least one breast, and which allowed calculation of the prevalence of incidental breast cancer or precursor lesions. Data were pooled using logistic regression models with random intercepts (non-linear mixed models).ResultsWe included 13 studies from 1948 to 2010, contributing 2363 autopsies with 99 cases of incidental cancer or precursor lesions. More thorough histological examination (≥20 histological sections) was a strong predictor of incidental in-situ cancer and atypical hyperplasia (OR = 126·8 and 21·3 respectively, p < 0·001), but not invasive cancer (OR = 1·1, p = 0·75). The estimated mean prevalence of incidental cancer or precursor lesion was 19·5% (0·85% invasive cancer + 8·9% in-situ cancer + 9·8% atypical hyperplasia).ConclusionOur systematic review in ten countries over six decades found that incidental detection of cancer in situ and breast cancer precursors is common in women not known to have breast disease during life. The large prevalence pool of undetected cancer in-situ and atypical hyperplasia in these autopsy studies suggests screening programs should be cautious about introducing more sensitive tests that may increase detection of these lesions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Prevalence of incidental breast cancer and precursor lesions in autopsy studies: a systematic review and meta-analysis

et al. 2017

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“…However, little is known about its biological nature including its premalignant character. We have already reported the incidence of epithelial hyperplasia of the breast associated with the expression of blood group antigens (1) and its proliferative activity using AgNORs and Ki‐67 labeling index (2). In these reports, the lesions of epithelial hyperplasia were characterized by an intermediate nature between normal ductal epithelium and carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Loss of heterozygosity and microsatellite instability in epithelial hyperplasia of the breast

et al. 2002

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We evaluated loss of heterozygosity (LOH) and microsatellite instability (MSI) in epithelial hyperplasia of the breast by the PCR method using microsatellite markers. Seven loci of 16q, 17p, 17q, and 18q were examined in 35 lesions of epithelial hyperplasia observed in non-neoplastic breast tissue of eight breast carcinoma cases, and 29 lesions were observed within 19 fibroadenomas. These hyperplastic lesions were classified by standard criteria into three groups, namely, mild, moderate and atypical ductal hyperplasia (ADH). In the breast carcinoma cases, the frequency of loss of heterozygosity was 40% in mild, 50% in moderate, and 100% in ADH; while in the fibroadenoma cases, the frequency was 10% in mild, 27% in moderate, and 25% in ADH; total frequency of LOH was statistically higher in carcinoma cases than in fibroadenoma cases. On the other hand, the frequency of microsatellite instability was higher in fibroadenoma cases (28%) than in breast carcinoma cases (11%). Furthermore, we analyzed two cases of noninvasive ductal carcinoma arising in fibroadenoma, which had various types of hyperplasia along with carcinoma in situ, and many hyperplasias showed LOH at several of the same markers as carcinoma in situ. From those results, we speculated that LOH at these markers is an early event in mammary tumorigenesis, and some of the hyperplastic lesions with LOH have precancerous natures.

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Prevalence of Abnormal Levels of Serum Tumour Markers in Elderly People

et al. 1996

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The study was conducted to evaluate the prevalence of abnormal levels of several serum tumour markers in an institutionalized elderly population. Serum tumour markers assay of carcinoembryonic antigen (CEA), the carbohydrate antigens CA 19-9, CA 72-4 and CA 15-3 (Enzymun-test, Boehringer Mannheim GmbH Diagnostic), alpha-fetoprotein (AFP) and prostate specific antigen (PSA) (Abbot Diagnostic Division) were performed in 228 unselected, institutionalized elderly subjects, whose mean age (SD) was 82.4 (5. 79) range (66-99 years). Patients with acute or neoplastic diseases were excluded from the study. The serum markers were also measured in 52 healthy young adults (controls). Using the established threshold values, 92 subjects (40%) were found to have at least one elevated marker. PSA was elevated in 33%, CA 19-9 in 16%, CEA in 11. 5%, CA 15-3 in 11%, CA 72-4 in 8% and AFP in 3%. We found a significant difference in the serum levels between the two groups for CEA, CA 19-9. CA 15-3, and PSA (p < 0.0001). Healthy aged people appear to have an elevated prevalence of elevated levels of serum tumour markers. The results suggest that apart from PSA, elevated antigen levels in elderly subjects are related to the ageing process itself rather than to occult pathology.

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Epithelial Hyperplasia of the Breast: Comparison of Incidence between Cases of Breast Carcinoma and Control Autopsy Specimens with Immunohistochemical Observation of Blood Group Antigens

Cited by 3 publications

References 21 publications

Prevalence of incidental breast cancer and precursor lesions in autopsy studies: a systematic review and meta-analysis

Prevalence of incidental breast cancer and precursor lesions in autopsy studies: a systematic review and meta-analysis

Loss of heterozygosity and microsatellite instability in epithelial hyperplasia of the breast

Prevalence of Abnormal Levels of Serum Tumour Markers in Elderly People

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