Epithelial Healing and the Transplantation of Skin

Brown, James Barrett; McDowell, Frank

doi:10.1097/00000658-194206000-00027

Cited by 68 publications

(24 citation statements)

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“…The epithelium can be restored by the migration of epithelial cells from the old epithelium adjoining a wound or by centrifugal migration from any hair follicle that remains within the wound (14). Several studies have unambiguously identified the hair follicle as a major reserve of adult stem cells (15,16).…”

Section: Discussionmentioning

confidence: 99%

Hair follicle units promote re-epithelialization in chronic cutaneous wounds: A clinical case series study

Liu

Zhao

2015

Experimental and Therapeutic Medicine

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Abstract. Chronic cutaneous wounds are one of the most unfavorable pathophysiological processes in routine practice. However, developments in hair follicle unit therapy may aid the treatment of these wounds. The aim of the present study was to investigate the function of hair follicle units in chronic cutaneous wound re-epithelialization and to develop an effective protocol for wound treatment. A total of 14 patients, of which nine were male and five were female, with a mean age of 60.71 years (range, 19-76 years) and a mean wound area of 74.14 cm 2 , were treated in the study. The hair follicle units were dissected from a scalp graft and transplanted into the chronic cutaneous wound bed, after which clinical evaluation was performed. Images of the recipient site were captured at 0, 1, 2, 3, 4, 5, 8 and 14 weeks following transplantation. In addition, histological examinations were conducted postoperatively at week 16. Total wound re-epithelialization was observed in all the patients. Histological analysis revealed that the epidermis and papillary dermis were present in the wound area. Adnexal structures and the reticular dermis were also observed. Therefore, the present study demonstrated the ability of hair follicle units to promote chronic cutaneous wound healing.

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Section: Discussionmentioning

confidence: 99%

Hair follicle units promote re-epithelialization in chronic cutaneous wounds: A clinical case series study

Liu

Zhao

2015

Experimental and Therapeutic Medicine

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“…3 It is notable that hair-covered areas recover sooner than hairless areas following skin injury, as re-epithelialization spreads from the hair follicle infundibulum. 4,5 This suggests that hair follicle keratinocytes may contribute to re-epithelialization of the interfollicular epidermis.…”

Section: Introductionmentioning

confidence: 99%

Epidermal Structure Created by Canine Hair Follicle Keratinocytes Enriched with Bulge Cells in a Three‐Dimensional Skin Equivalent Model in Vitro: Implications for Regenerative Therapy of Canine Epidermis

Kobayashi¹,

Enomoto²,

Wang³

et al. 2013

Advances in Veterinary Dermatology

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“…Investigators and clinicians have long noted that hair-bearing areas tend to heal more quickly than areas lacking follicles [9,10]. The exact relationship between cutaneous wound healing and the hair follicle cycle is slowly being unraveled.…”

Section: Introductionmentioning

confidence: 99%

Small cutaneous wounds induce telogen to anagen transition of murine hair follicle stem cells

Jiang

Zhao

Teklemariam

et al. 2010

Journal of Dermatological Science

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Epithelial Healing and the Transplantation of Skin

Cited by 68 publications

References 0 publications

Hair follicle units promote re-epithelialization in chronic cutaneous wounds: A clinical case series study

Hair follicle units promote re-epithelialization in chronic cutaneous wounds: A clinical case series study

Epidermal Structure Created by Canine Hair Follicle Keratinocytes Enriched with Bulge Cells in a Three‐Dimensional Skin Equivalent Model in Vitro: Implications for Regenerative Therapy of Canine Epidermis

Small cutaneous wounds induce telogen to anagen transition of murine hair follicle stem cells

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