Epithelial dysplasia of the oral mucosa—Diagnostic problems and prognostic features

Bouquot, Jerry E.; Speight, Paul M.; Farthing, Paula M.

doi:10.1016/j.cdip.2005.10.008

Cited by 99 publications

(87 citation statements)

References 33 publications

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“…The specific brand of tobacco used, extended duration of habit, increased frequency of use, excessive daily contact-hours of tobacco on oral mucous membranes, and a deficiency of betacarotene or vitamin A also contribute to a high risk of keratosis. 17 Smears obtained in the second phase of our study were analyzed. Both Exfoliative cytology and LBC did not show any atypical cells.…”

Section: Resultsmentioning

confidence: 99%

Smokeless Tobacco-associated Lesions: A Mobile Health Approach

Desai

Birur

Bajaj

et al. 2015

The Journal of Contemporary Dental Practice

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Aim: Globally, India accounts for the highest number of oral cancer cases. The survival rates are about 30% lower than those in developing countries. The main reason for these dismal figures is the late presentation of patients. In order to downstage oral cancer in such a scenario, screening and diagnosis at an early stage is warranted. A pragmatic approach is needed for an oral cancer screening program, hence a mobile health (mHealth) approach was used. In this approach, health workers were empowered with mobile phones with decision-based algorithm. Risk stratification of tobacco habit enables us to identify lesions associated with particular habits. Materials and methods:A specific cohort of factory employees who predominantly had pure tobacco chewing habit was chosen to examine the effect of pure tobacco on oral mucosa. One thousand three hundred and fifty-seven subjects were screened in two phases. In the first phase, habits and oral lesions were identified and photographed. The photographs were remotely diagnosed by an oral medicine specialist and those subjects requiring biopsy were recalled for phase II. Cytology and biopsy were performed in phase II.

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Section: Resultsmentioning

confidence: 99%

Smokeless Tobacco-associated Lesions: A Mobile Health Approach

Desai

Birur

Bajaj

et al. 2015

The Journal of Contemporary Dental Practice

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“…6 However, this data has changed as recent studies have demonstrated an increase in malignant transformation rates now ranging from 8.9% to 17.5%. 32,33 However, there are no genetic biomarkers to predict which OLs will be quiescent or will rapidly become invasive squamous cell carcinoma. 12 In this study, we demonstrated an altered WWOX mRNA and/or protein expression in eight of 23 samples (35%) of OL.…”

Section: Discussionmentioning

confidence: 99%

“…33 While lesions with severe dysplasia are prone to malignant transformation, this alteration is also found in OLs with mild dysplasia. Up to now, no molecular markers have been demonstrated as good prognostic predictors of potentially malignant oral lesions.…”

Section: Discussionmentioning

confidence: 99%

Molecular alterations in the tumor suppressor gene WWOX in oral leukoplakias

et al. 2008

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SummaryOral leukoplakia is the most prevalent and potentially malignant disorder of the oral mucosa. Previous studies have demonstrated that molecular changes of the WWOX gene (WW-domain containing oxidoreductase), a candidate tumor suppressor gene located at 16q23.3-24.1 that spans FRA16D, the second most common fragile site, are present in several malignant neoplasias, including oral squamous cell carcinoma. In this report, the role of the WWOX gene was investigated in 23 cases of oral leukoplakias. Using nested RT-PCR and immunohistochemistry, altered mRNA transcription and/or reduced Wwox protein expression was observed in 35% of the lesions when compared with normal mucosa. The majority of lesions (4/6) with altered transcripts had a reduction in the expression of Wwox protein. Although normal WWOX expression was found in some lesions with dysplasia, all lesions with WWOX mRNA and/or protein expression showed histological evidence of dysplasia and none of the cases without dysplasia presented this alteration. These results show that the WWOX gene alteration is an early genetic alteration and may contribute to oral carcinogenesis.

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“…In the oral cavity, use of the SIL terminology of 'atypical hyperplasia' may lead to confusion because of the large number of common benign hyperplastic lesions, which may be encountered. In oral and maxillofacial pathology therefore, oral epithelial dysplasia is regarded as the standard terminology [2,3].…”

Section: Introductionmentioning

confidence: 99%