Epithelial dysplasia and squamous cell carcinoma of the wistar rat palatal mucosa: 4NQO model

Nauta, Jan M.; Roodenburg, Jan; Nikkels, Peter G. J.; Witjes, Max; Vermey, A

doi:10.1002/(sici)1097-0347(199609/10)18:5<441::aid-hed7>3.3.co;2-n

Cited by 7 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specifically, on animals in which this carcinogen has been applied, the development of histological atypia increases as the exposure time to 4-NQO increases. 115 In fact, all animals in this study in which 4-NQO was applied to the palatal mucosa eventually developed oral SCC. These investigators compared these changes with specimens of human oral epithelial dysplasia.…”

Section: 106mentioning

confidence: 73%

“…Thus, multiple studies, in addition, to the above appear agree that 4-NQO reliably produce preneoplastic and malignant oral cavity lesions, which morphologically and histologically mimic human head and neck cancer. 92,109,115,116 Although the temporal progression of dysplastic lesions induced by 4-NQO and the morphologic appearance of the lesions in the mice palate mimic HNSCC in humans, the lengthy time to tumor development and the resistance to neoplastic transformation may be considered a relative disadvantage of this model. The study by Hawkins et al, however, showed that with 4-NQO application, the mice tongue consistently developed more advanced premalignant changes and earlier cancerous lesions than the palate.…”

Section: 106mentioning

confidence: 99%

“…Specifically, human clinical disease tends to metastasize to regional lymph nodes and may invade perineural tissues, whereas these aggressive features are rarely seen in 4-NQO-induced chemical carcinogenesis. 6,115 Other models of 4-NQO-induced chemical carcinogenesis Several groups have recently applied 4-NQO-based oral cavity chemical carcinogenesis protocols to mice, and showed the development of flat squamous dysplasias, papillomas and invasive HNSCC. 39,116,118 Steidler and Reade observed the development of oral epithelial atypia and SCC with increasing prevalence as the period of 4-NQO exposure was increased with carcinomas developing by 50 weeks in all mice exposed to this carcinogen for 16 weeks.…”

Section: 106mentioning

confidence: 99%

See 2 more Smart Citations

Animal models for the study of squamous cell carcinoma of the upper aerodigestive tract: A historical perspective with review of their utility and limitations. Part A. Chemically‐induced de novo cancer, syngeneic animal models of HNSCC, animal models of transplanted xenogeneic human tumors

Smith

Thomas

2005

Intl Journal of Cancer

View full text Add to dashboard Cite

Understanding the complex histological, genetic and molecular changes that lead to malignant transformation of squamous epithelia of the head and neck will likely guide the development of methods for improved diagnosis, monitoring and treatment of head and neck squamous cell carcinoma (HNSCC). The development and use of animal models that closely mimic the histopathology and molecular pathogenesis of HNSCC in humans would greatly expand the research possibilities and provide a means of testing potential therapeutic agents. However, many available animal models of HNSCC fall short of this objective. In order for investigators to select the appropriate model to answer scientific questions, it is important to understand the benefits and limitations of available animal models for the study of HNSCC. The purpose of this work is to give an overview of the most pertinent animal models of HNSCC, and to discuss future directions of research in this field. ' 2005 Wiley-Liss, Inc.Head and neck squamous cell carcinoma (HNSCC) involves the upper aerodigestive tract and can destroy the structure and function of organs involved in voice, speech, taste, smell and hearing, as well as vital structures necessary for survival. Approximately half of all patients with HNSCC have advanced stage disease at the time of diagnosis, with an expected 5-year survival rate between 10 and 40%.1 Despite treatments that may consist of mutilating surgery, radiotherapy and/or chemotherapy, overall long-term survival remains low due to uncontrollable persistent or recurrent disease. The survival rate of patients with locoregional and distant recurrences has highlighted the need for new approaches for diagnosis and treatment. To this end, a better understanding of the genetic, molecular and immunoregulatory processes leading to neoplastic transformation and progression of HNSCC is needed, so that novel and more effective diagnostic and therapeutic approaches can be designed.Although in vitro study systems are useful for studying the interactions between different cell populations in culture and are convenient and simple to use, they do not reproduce the complexity of HNSCC. For this reason, the development of new therapies will require clinically relevant animal models of HNSCC. Adequate animal models are necessary to test the translational potential of preventive and therapeutic agents, as well as to understand the biological mechanisms of epithelial carcinogenesis and progression. The ideal experimental animal tumor model for HNSCC must reproduce the characteristic features of the disease, including the complicated patterns of tumor-host interactions such as immune response, angiogenesis, invasion and metastasis. In the ideal model, clinical symptoms and laboratory abnormalities should be similar to the human disease and therapeutic agents should be as effective in both systems. The ideal model must also be easy to use, accessible to genetic and immunologic manipulations, reproducible and progress rapidly to allow timely investigations.Animal mod...

show abstract

Section: 106mentioning

confidence: 73%

Section: 106mentioning

confidence: 99%

Section: 106mentioning

confidence: 99%

See 1 more Smart Citation

Animal models for the study of squamous cell carcinoma of the upper aerodigestive tract: A historical perspective with review of their utility and limitations. Part A. Chemically‐induced de novo cancer, syngeneic animal models of HNSCC, animal models of transplanted xenogeneic human tumors

Smith

Thomas

2005

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Structures of 4NQO and its metabolites (Koontongkaew et al, 2000). because the oral mucosa of these animals is similar to human oral mucosa, especially in palate and tongue (MacDonald; Nauta et al, 1996). Another advantage of this model is the possibility of chemical management in systemic, long-term and lower doses, reducing further adverse effects (Vered et al, 2005).…”

Section: Experimental Oral Carcinogenesismentioning

confidence: 99%

“…Experimental protocols used vary extensively, however, concentrations of carcinogen used are similar (Steidler & Reade;Nauta et al, 1996;.…”

Section: Experimental Oral Carcinogenesismentioning

confidence: 99%

4NQO Carcinogenesis: A Model of Oral Squamous Cell Carcinoma

Rivera¹

2012

Int. J. Morphol.

View full text Add to dashboard Cite

show abstract

Localization of liposomal mTHPC formulations within normal epithelium, dysplastic tissue, and carcinoma of oral epithelium in the 4NQO‐carcinogenesis rat model

et al. 2013

View full text Add to dashboard Cite

In our induced carcinogenesis model, Fospeg exhibited a tendency for higher fluorescence in normal and tumor tissue compared to Foslip and Foscan. In contrast to Foscan and Foslip, Fospeg showed significantly higher fluorescence in tumor versus normal tissue at earlier time points, suggesting a possible clinical benefit compared to Foscan. Low correlation between grade of dysplasia and mTHPC fluorescence was found.

show abstract

Epithelial dysplasia and squamous cell carcinoma of the wistar rat palatal mucosa: 4NQO model

Cited by 7 publications

References 0 publications

Animal models for the study of squamous cell carcinoma of the upper aerodigestive tract: A historical perspective with review of their utility and limitations. Part A. Chemically‐induced de novo cancer, syngeneic animal models of HNSCC, animal models of transplanted xenogeneic human tumors

Animal models for the study of squamous cell carcinoma of the upper aerodigestive tract: A historical perspective with review of their utility and limitations. Part A. Chemically‐induced de novo cancer, syngeneic animal models of HNSCC, animal models of transplanted xenogeneic human tumors

4NQO Carcinogenesis: A Model of Oral Squamous Cell Carcinoma

Localization of liposomal mTHPC formulations within normal epithelium, dysplastic tissue, and carcinoma of oral epithelium in the 4NQO‐carcinogenesis rat model

Contact Info

Product

Resources

About