Epithelial Changes in Seasonal Allergic Rhinitis throughout the Year: Evidence of Coexistent Air Pollution and Local Secretory IgA Deficiency?

Glück, Ulrich; Gebbers, Jan‐Olaf

doi:10.1159/000027720

Cited by 29 publications

(21 citation statements)

References 16 publications

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“…While this result was contrary to our original hypothesis, it should be noted that goblet cell hyperplasia is not a consistent feature of allergic rhinitis in people. A transient increase in intraepithelial mucosubstances has been noted in patients with allergic rhinitis following exposure to allergen [50,51]. In contrast, other studies found no change in nasal intraepithelial mucosubstances in allergic rhinitis patients [52,53].…”

Section: Discussionmentioning

confidence: 99%

Histopathologic and Morphometric Evaluation of the Nasal and Pulmonary Airways of Cats with Experimentally Induced Asthma

Venema

Williams²,

Gershwin

et al. 2012

Int Arch Allergy Immunol

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Background: Allergic rhinitis frequently occurs as a comorbid condition in asthmatic people, suggesting that the upper and lower airways may be immunologically linked. Our research group has developed an experimental aeroallergen model of asthma in cats. We hypothesized that aeroallergen sensitization and challenge would induce morphologic changes in the nasal airways of cats that mimic those observed in the bronchial airways. Methods: Five mixed breed cats were sensitized to Bermuda grass allergen and then serially challenged with aerosolized Bermuda grass allergen to induce an asthmatic phenotype. Four control cats were similarly treated with saline vehicle. Nasal tissues and lungs were processed for histopathological and morphometric analyses. Results: Eosinophilic inflammation, epithelial hypertrophy and mucous cell metaplasia were observed along the pulmonary axial airway mucosa of allergen-sensitized (asthmatic) cats. Mild eosinophilic inflammation was observed in the nasal airways of asthmatic cats. This alteration was confined primarily to the anterior nasal cavity, resulting in an increase in tissue eosinophils at this site compared to controls (p < 0.05). A marked increase in tissue mast cells was observed throughout all regions of the nasal airways of asthmatic cats compared to control cats (p < 0.05). There was no difference in intraepithelial mucosubstances between the nasal airways of controls and asthmatic cats. There was no correlation between upper and lower airway eosinophils or mast cells. Conclusion: Cats with experimentally induced asthma exhibit morphologic changes in the nasal airways that are distinct from the alterations observed in the lungs. These results are similar to those observed in people with comorbid asthma and allergic rhinitis.

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Section: Discussionmentioning

confidence: 99%

Histopathologic and Morphometric Evaluation of the Nasal and Pulmonary Airways of Cats with Experimentally Induced Asthma

Venema

Williams²,

Gershwin

et al. 2012

Int Arch Allergy Immunol

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“…Epithelial damage is only minimal in the nasal mucosa of patients with allergic rhinitis (810)(811)(812). Moreover, epithelial cell metaplasia has been observed in the nasal biopsies of some patients suffering from perennial rhinitis (813,814).…”

Section: Allergic Inflammationmentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,812

1,761

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“…The established allergic sensitization against seasonal grass pollen of some subjects played a major role in this study. Since similar observations were made in a previous study [27] , a relation to the study medication could be ruled out.…”

Section: Discussionmentioning

confidence: 82%

A Clinical Study on the Tolerability of a Liposomal Povidone-Iodine Nasal Spray: Implications for Further Development

Glück¹,

Martin²,

Bosse³

et al. 2006

ORL

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Purpose of Study: This phase I study assessed tolerability and local effect of a liposome dispersion with povidone-iodine (polyvinylpyrrolidone-iodine, PVP-I) as nasal spray. Procedures: Three groups received liposomal dispersion with PVP-I (2.2, 4.4 and 0% as control) in single and repeated use (3 days, three times a day). A set of functional and cytological tests as well as safety assessments were performed. Results: No safety-relevant finding or serious adverse events were reported, no evidence for cyto- nor genotoxicity obtained. No clinically relevant changes in mucosa appearance, nor in olfactory sense, nor in ciliary activity (sensitive indicator of local tolerance) occurred and no complaints about nasal airflow obstruction were observed. All liposomal formulations had a positive effect on the nasal mucosa, challenged by allergy in some volunteers. Conclusions and Message: Application of liposomal PVP-I spray to the nasal mucosa does not result in any demonstrable limitation of the nasal function nor in detectable damage to the multilayer ciliated epithelium of the nose. Improvement of various parameters of nasal function under liposomal PVP-I suggest improved mucociliary clearance. Explanation could be humidification, improved surfactant (phospholipid) level and/or sufficient mucolytic activity of iodide due to local application of the constituents.

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Epithelial Changes in Seasonal Allergic Rhinitis throughout the Year: Evidence of Coexistent Air Pollution and Local Secretory IgA Deficiency?

Cited by 29 publications

References 16 publications

Histopathologic and Morphometric Evaluation of the Nasal and Pulmonary Airways of Cats with Experimentally Induced Asthma

Histopathologic and Morphometric Evaluation of the Nasal and Pulmonary Airways of Cats with Experimentally Induced Asthma

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

A Clinical Study on the Tolerability of a Liposomal Povidone-Iodine Nasal Spray: Implications for Further Development

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