Abstract:Epithelial cells display their nature of integral, resident components of the innate immune system, and provide a valid defensive line against environmental threats through the expression of a plethora of active mediators, including antimicrobial peptides, cytokines, chemokines and cell membrane molecules. By contrast, epithelial cells can play a relevant role in the pathogenesis of chronic inflammatory disorders (e.g. atopic dermatitis and psoriasis), where the amplification of the inflammatory reactions crit… Show more
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