Epithelial cell transformation sequence 2 is a potential biomarker of unfavorable survival in human gliomas

Abstract

ECT2 expression is positively correlated with WHO pathologic grading and unfavorable survival, suggesting that ECT2 may be a potential therapeutic candidate in human gliomas.

Elevated expression of ECT2 predicts unfavorable prognosis in patients with colorectal cancer

“…It is well described in the literature that upregulation of ECT2 confers poor clinical outcome in many different types of tumors [14,15,[18][19][20]. However, a comprehensive investigation remains to evaluate the clinical significance and prognostic value of ECT2 in CRC specifically.…”

“…Those characteristics of ECT2 indicate that the mislocalization to the cytoplasm may enhance ECT2 oncogenic potential. Indeed, overexpressed ECT2 is identified in many types of human malignancies, including pancreatic cancer [12], lung cancer [13], glioma [14,15], breast cancer [16], etc. And increased ECT2 activates several Rho-regulated signaling pathway, which ultimately contribute to malignant transformation [10].…”

Clinicopathological and prognostic significance of epithelial cell transforming sequence 2 expression in cancers: a systematic review and meta-analysis

“…A total of 19 published articles with 21 studies enrolling 5,305 patients met the inclusion criteria for the meta-analysis [11,15,[19][20][21][22][23][24][25][32][33][34][35][36][37][38][39][40][41]. A flow diagram of the detailed literature selection process is displayed in Figure 1.…”

“…Indeed, growing evidence suggests that ECT2 is frequently overexpressed in various cancers and serves as an oncogene [15][16][17][18]. Moreover, numerous clinical studies have shown that high ECT2 expression is associated with adverse clinicopathological characteristics, such as poor tumour differentiation, larger tumour size, positive lymphatic metastasis, and advanced disease stage, and as well as an unfavourable prognosis in multiple type of cancers [11,15,[19][20][21][22][23][24][25], further suggesting that it is a promising prognostic biomarker in cancers. Nevertheless, these previous studies are limited by sample sizes or study methodologies.…”

MicroRNA-130b promotes cell migration and invasion by inhibiting peroxisome proliferator-activated receptor-γ in human glioma

“…The World Health Organization (WHO) classification grades glioma between well differentiated low grade glioma, WHO grades I–II, and high grade anaplastic glioma and glioblastoma, WHO grades III and IV, respectively (5). A higher grade glioma is associated with poor prognosis and increased mortality (6). Therefore, revealing the detailed molecular mechanism and the diagnostic and prognostic markers of glioma is crucial for the prediction of clinical outcomes.…”