Epithelial cell proliferation in the mouse vagina during the estrous cycle, pregnancy and lactation: A radioautographic study

Traurig, Harold H.

doi:10.1002/ar.1091700407

Cited by 8 publications

(3 citation statements)

References 29 publications

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“…The variation of E2 during gestation in Mongolian gerbils is similar to those in rats and mice, in which the E2 level gradually increases during early gestation, reaching a peak during embryo implantation, and then continuously increases, reaching a peak before parturition [3,15,26,32]. In the present study, the pattern of P4 levels during gestation was similar to those observed in previous works [11,12], but differed from those detected in rats and mice.…”

Section: Hormonal Variations During Gestation In Primiparous Mongoliasupporting

confidence: 88%

Variations of Serum Estradiol and Progesterone Levels during Consecutive Reproductive States in Mongolian Gerbils (Meriones unguiculatus)

Shi

2010

Exp. Anim.

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Serum estradiol (E2) and progesterone (P4) levels were measured by chemiluminescence immunoassay (CLIA) during consecutive reproductive states in Mongolian gerbils. The results show that E2 and P4 levels throughout the estrous cycle in Mongolian gerbils peaked at proestrus and estrus, respectively. During gestation in primiparous and multiparous gerbils, E2 levels reached a small peak on day 6 and a maximum peak on day 21, followed by a slight decline until parturition. Thereafter, they dropped sharply during the first 3 days of lactation and remained stable until lactation ended. P4 levels reached a peak on day 12 during gestation in primiparous gerbils, while they peaked on day 6 in multiparous gerbils. The levels of P4 then decreased until parturition. During lactation, P4 levels peaked on day 9 in primiparous gerbils, while they peaked on day 6 in multiparous gerbils, and then the levels declined gradually until lactation ended. The findings suggest that the variations of E2 levels during the estrous cycle, gestation and lactation in Mongolian gerbils are similar to those observed in rats and mice. Changes in E2 levels during different reproductive states were the same in the primiparous and multiparous gerbils, but the variations in P4 levels did not display this tendency. Changing patterns of E2 and P4 levels are suitable for the reproductive stages of Mongolian gerbils.

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Section: Hormonal Variations During Gestation In Primiparous Mongoliasupporting

confidence: 88%

Variations of Serum Estradiol and Progesterone Levels during Consecutive Reproductive States in Mongolian Gerbils (Meriones unguiculatus)

Shi

2010

Exp. Anim.

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“…The generative compartment is a homogeneous population of actively proliferating cells. The same basal cells can give rise to either a stratified squamous keratinized or a nonkeratinized epithelium [Barker and Walker, 1966;Traurig, 1971;Montes and Luque, 1988]. Keratohyalin and MCGs and the resulting barrier formation are organelles produced in the stratum spinosum and granulosum cells [Westerhof and Dingemans, 1987].…”

Section: Discussionmentioning

confidence: 99%

Changes in the Epithelium of the Vaginal Complex during the Estrous Cycle of the Marsupial <i>Monodelphis domestica</i>

Regli

Kress²

2002

Cells Tissues Organs

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The vaginal complex of marsupials differs from that of eutherians. Cervices open separately in a sinus vaginalis or cul-de-sac. Two lateral vaginae adjoin the sinus vaginalis and fuse at the level of the urethra opening and form the sinus urogenitalis. During the estrous cycle the vaginal epithelium undergoes a number of specified morphological changes. This paper is the first to describe these changes on an ultrastructural level in a marsupial. Investigations in Monodelphis vagina reveal that a cyclic switch exists between a keratinized and a stratified nonkeratinized epithelium. Keratinization starts during proestrus and reaches its maximum during estrus. In the postestrus, desquamation of the stratum corneum takes place, mostly in two steps. In metestrus one to two additional layers of the now nonkeratinized surface cells are shed into the vaginal lumen. Typical cell structures, such as keratin filaments, keratohyalin and membrane-coating granules, are involved in the keratinization process. Keratohyalin is found in the cytoplasm as well as in the nucleus of stratum granulosum cells, a phenomenon which is known from other parakeratinized epithelia of rapid turnover. Membrane-coating granules, responsible for the permeability barrier between the epithelial cells, are of the nonlamellated type in the nonkeratinized epithelium and produce an amorphous material in the intercellular spaces after extrusion. At periods, however, when the epithelium is keratinized, membrane-coating granules are of the lamellated type and form a lamellated barrier structure after extrusion in the intercellular space. The loss of the protective keratinized layers asks for an additional defense mechanism for the epithelium. The migration of leukocytes through the epithelium predominantly during post- and metestrus and their presence in the vaginal lumen may play a protective role together with the bacterial content.

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“…Vaginal epithelial differentiation and its hormonal regulation have been analyzed in detail by autoradiography (Galand et al, 1971;Traurig, 1971;Husbands and Walker, 1963), electron microscopy (Hayashi et al, 1988;Eddy and Walker, 1966). histochemistry (Putti and Varano, 1979;Green, 1959), and in tissue culture (Cooke et al, 1986;Iguchi et al, 1983).…”

Section: Introductionmentioning

confidence: 99%

Glycoproteins of mouse vaginal epithelium: differential expression related to estrous cyclicity.

Horvat

Multhaupt²,

Damjanov³

1993

J Histochem Cytochem.

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We used lectin overlay blotting and SDS-PAGE to analyze the estrous cycle-specific expression of mouse vaginal epithelial glycoproteins. Seven leains chosen for theit Werential carbohydrate-binding specificity revealed 15 glycoproteins that showed cycle-related expression. Each lectin had a unique binding pattern di&rent from the pattems revealed by other l&.However, several estrous cycle phase-specific glycoproteins reacted with more than one lectin. The most prominent of these glycoproteins (MI 92-95 KD) was weakly expressed in late diestrus and filly e x p r d only in proestrus, coincident with the transformation of two superficial layers

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Epithelial cell proliferation in the mouse vagina during the estrous cycle, pregnancy and lactation: A radioautographic study

Cited by 8 publications

References 29 publications

Variations of Serum Estradiol and Progesterone Levels during Consecutive Reproductive States in Mongolian Gerbils (Meriones unguiculatus)

Variations of Serum Estradiol and Progesterone Levels during Consecutive Reproductive States in Mongolian Gerbils (Meriones unguiculatus)

Changes in the Epithelium of the Vaginal Complex during the Estrous Cycle of the Marsupial <i>Monodelphis domestica</i>

Glycoproteins of mouse vaginal epithelium: differential expression related to estrous cyclicity.

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